Manufacturer: Hangzhou Royalchem Co.,LTD.

Website:  www.cnroyalchem.com

Product Description: 4-Bromo-2-fluoroaniline (CAS 367-24-8)

1. Chemical Identification

Chemical Name:  4-Bromo-2-fluoroaniline

Synonyms:

2-Fluoro-4-bromoaniline

4-Bromo-2-fluoro-benzenamine

Benzenamine, 4-bromo-2-fluoro-

4-Br-2-F-aniline

CAS Registry Number:  367-24-8

Molecular Formula:  C₆H₅BrFN

Molecular Weight:  190.02 g/mol

2. Physical and Chemical Properties

Appearance:  Typically a pale yellow, yellow, tan, or light brown crystalline solid or powder. 

Odor:  Characteristic amine-like odor.

Melting Point:  Approximately 49-53 °C (literature values may vary slightly, commonly reported ~50-52 °C).

Boiling Point:  Decomposes before boiling under normal conditions.

Density:  ~1.7 g/cm³ (estimated).

Solubility:

Soluble in:  Common organic solvents such as ethanol, methanol, acetone, ethyl acetate, dichloromethane, chloroform, dimethylformamide (DMF), dimethyl sulfoxide (DMSO), and diethyl ether.

Slightly soluble in:  Water.

Stability:  Stable under recommended storage conditions. Sensitive to air and light (can oxidize over time, potentially darkening). Moisture sensitive. Incompatible with strong oxidizing agents, strong acids, acid chlorides, and acid anhydrides. 

Refractive Index:  Not typically specified/relevant for solid.

3. Hazard Identification (GHS Classification - Typical)

Acute Toxicity (Oral):  Category 4 (Harmful if swallowed) - H302

Acute Toxicity (Dermal):  Category 4 (Harmful in contact with skin) - H312

Acute Toxicity (Inhalation):  Category 4 (Harmful if inhaled) - H332

Skin Corrosion/Irritation:  Category 2 (Causes skin irritation) - H315

Serious Eye Damage/Irritation:  Category 2A (Causes serious eye irritation) - H319

Specific Target Organ Toxicity (Single Exposure):  Category 3 (Respiratory tract irritation) - H335 (May cause respiratory irritation)

Hazardous to the Aquatic Environment (Acute):  Category 3 - H402 (Harmful to aquatic life) 

GHS Pictograms:  (Health Hazard), (Exclamation Mark), (Environment - optional depending on supplier assessment)

Signal Word:   Warning

Precautionary Statements (Examples):

P261: Avoid breathing dust/fume/gas/mist/vapours/spray.

P264: Wash skin thoroughly after handling.

P270: Do not eat, drink or smoke when using this product.

P271: Use only outdoors or in a well-ventilated area.

P280: Wear protective gloves/protective clothing/eye protection/face protection.

P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.

P302 + P352: IF ON SKIN: Wash with plenty of soap and water.

P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.

P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P312: Call a POISON CENTER or doctor/physician if you feel unwell.

P330: Rinse mouth.

P332 + P313: If skin irritation occurs: Get medical advice/attention.

P337 + P313: If eye irritation persists: Get medical advice/attention.

P362: Take off contaminated clothing and wash before reuse.

P403 + P233: Store in a well-ventilated place. Keep container tightly closed.

P405: Store locked up.

P501: Dispose of contents/container in accordance with local/regional/national/international regulations.

4. Handling and Storage

Handling:  Handle in a well-ventilated area, preferably a fume hood. Wear appropriate personal protective equipment (PPE): chemical-resistant gloves (e.g., nitrile, neoprene), safety goggles or face shield, and lab coat. Avoid contact with skin, eyes, and clothing. Avoid breathing dust or vapors. Do not eat, drink, or smoke in areas where this chemical is handled. Wash hands thoroughly after handling.

Storage:  Store in a cool, dry, well-ventilated place away from direct sunlight and heat sources. Keep container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation and moisture uptake. Store away from incompatible materials (strong oxidizers, strong acids). Store locked up according to local regulations. Store at temperatures recommended by the supplier, often 2-8°C (refrigerated) for long-term stability.

5. Applications

Primary Use:   Versatile Synthetic Building Block / Organic Intermediate.

Key Applications:

Pharmaceutical Intermediates:  Synthesis of active pharmaceutical ingredients (APIs), particularly those requiring substituted aniline motifs. The bromine atom allows for further functionalization (e.g., via Suzuki-Miyaura coupling).

Agrochemical Intermediates:  Building block for herbicides, insecticides, and fungicides.

Dye and Pigment Intermediates:  Used in the synthesis of complex dyes and pigments.

Material Science:  Potential monomer or intermediate for specialty polymers or liquid crystals.

Organic Synthesis:  Useful substrate for various reactions:

Electrophilic Aromatic Substitution (directed by -NH₂, though moderated by F and Br).

Diazotization followed by Sandmeyer reactions or coupling (replacing -NH₂).

Nucleophilic Aromatic Substitution (potential site ortho to F, activated by Br and -NH₂).

Metal-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Sonogashira using the Br substituent).

Protection/Deprotection of the amino group.