Manufacturer: Hangzhou Royalchem Co.,LTD.
Website: www.cnroyalchem.com
【 Providing a complete set of intermediates and impurities for Orforglipron 】
【 Providing a complete set of intermediates and impurities for Orforglipron 】
【 Providing a complete set of intermediates and impurities for Orforglipron 】
Here is a detailed product specification for 5-Bromo-4-fluoro-1-methyl-1H-indazole (CAS 1784678-61-0) :
Product Specification: 5-Bromo-4-fluoro-1-methyl-1H-indazole
Chemical Identification
Chemical Name: 5-Bromo-4-fluoro-1-methyl-1H-indazole
Synonyms: 1-Methyl-5-bromo-4-fluoroindazole; 5-Bromo-4-fluoro-1-methylindazole
CAS Registry Number: 1784678-61-0
Molecular Formula: C₈H₆BrFN₂
Molecular Weight: 229.05 g/mol
Physical and Chemical Properties
Melting Point: Not widely reported/standardized. Supplier-specific data should be consulted.
Solubility: Generally soluble in common organic solvents such as dimethyl sulfoxide (DMSO), dimethylformamide (DMF), dichloromethane (DCM), chloroform, and methanol. Sparingly soluble or insoluble in water.
Storage Conditions: Store in a cool, dry place. Recommended storage temperature is often -20°C under inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent degradation, especially for long-term storage. Keep container tightly sealed.
Stability: Stable under recommended storage conditions. Sensitive to moisture, air, and light over prolonged periods. Handle under an inert atmosphere where practical.
Applications
Primary Use: Pharmaceutical Intermediate / Building Block. This compound is primarily used as a versatile chemical building block in organic synthesis, particularly in medicinal chemistry and drug discovery research.
Target Areas:
Kinase Inhibitor Development: The indazole scaffold is a privileged structure found in numerous bioactive molecules, especially kinase inhibitors (e.g., targeting JAK, FLT3, CDK, Aurora kinases). The bromo and fluoro substituents offer specific points for further derivatization (e.g., via cross-coupling reactions like Suzuki, Stille, Sonogashira).
GPCR Modulator Development: Indazoles are also explored as ligands for various G-protein coupled receptors (GPCRs).
Fragment-Based Drug Discovery (FBDD): Can serve as a starting fragment.
Agrochemical Research: Potential use in developing novel active ingredients.
Material Science: Potential precursor for specialty materials (less common).
Handling and Safety (GHS Pictograms and Hazard Statements are illustrative - MUST be verified per SDS)
Hazard Classification: Classified as hazardous. Specific classifications (e.g., Acute Toxicity, Skin Irritation, Eye Irritation, Specific Target Organ Toxicity) depend on the supplier's testing and regulatory requirements. Always consult the Safety Data Sheet (SDS) provided with the specific batch.
Potential Hazards: May be harmful if swallowed, in contact with skin, or if inhaled. May cause skin irritation, serious eye irritation, or respiratory irritation. Potential long-term health effects may not be fully characterized.
Precautionary Statements (P-Statements - Examples, verify per SDS):
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P330: Rinse mouth.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P337+P313: If eye irritation persists: Get medical advice/attention.
P362: Take off contaminated clothing and wash before reuse.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container in accordance with local/regional/national/international regulations.
Personal Protective Equipment (PPE): Always wear appropriate PPE: Safety glasses or goggles, chemical-resistant gloves (e.g., nitrile, neoprene), lab coat, and consider respiratory protection (dust mask) if handling powder outside a fume hood. Work in a well-ventilated area, preferably a fume hood.
