l.Basic Information
1. English Name: Oxytocin Acetate
2. Other Names: α-Hypophamine, Pitocin, endopituitrina
3. Molecular Formula: C₄₃H₆₆N₁₂O₁₂S₂
4. Molecular Weight: 1007.19
5. Purity: ≥98% (HPLC)
II. Product Overview
Oxytocin Acetate is a peptide substance belonging to mammalian neurohypophyseal hormones. It consists of 9 amino acids, synthesized in the neurons of the paraventricular and supraoptic nuclei of the hypothalamus, and then transported to the neurohypophysis at a rate of 2-3 mm per day for release. This substance can specifically bind to oxytocin receptors with high affinity and plays a key role in the organism.
III. Physiological Functions
1. Promoting Childbirth: Oxytocin Acetate can stimulate the contraction of uterine smooth muscles, helping to initiate the labor process. During childbirth, it can strengthen the regular uterine contractions, facilitating the smooth delivery of the fetus, and is a commonly used drug in clinical induction and acceleration of labor. By regulating the frequency, intensity, and duration of uterine contractions, it makes the labor process smoother and reduces the risk of dystocia. For example, for pregnant women with post-term pregnancy or those needing to terminate pregnancy early for certain reasons, doctors will use oxytocin acetate reasonably according to specific conditions to induce labor.
2. Promoting Lactation: It can contract the smooth epithelial cells around the mammary alveoli, triggering the milk ejection reflex, promoting milk secretion and excretion, and facilitating breastfeeding. After childbirth, the level of oxytocin in the mother's body increases, which can promote the contraction of myoepithelial cells around the mammary alveoli, squeezing out the stored milk and providing nutritious breast milk for the newborn.
3. Prosocial Behavior: A growing number of studies have shown that Oxytocin Acetate is closely related to prosocial behaviors, including enhancing trust, promoting emotional connection, reducing anxiety, and decreasing aggression, playing an important role in social interaction and emotional communication. For example, in some animal experiments, after receiving an appropriate amount of oxytocin, the experimental animals showed more prosocial behaviors such as mutual contact and grooming. In humans, it also helps to strengthen emotional connections between people and improve trust and intimacy.
4. Stress Response: As a stress-response molecule, Oxytocin Acetate has anti-inflammatory, antioxidant, and protective effects, especially helping to maintain the body's internal environment stability when facing adversity or trauma. When the body encounters stress, the oxytocin system in the body is activated, helping to reduce inflammatory reactions and the damage of oxidative stress to cells and tissues.
IV. Clinical Applications
1. Induction and Acceleration of Labor: In the field of obstetrics and gynecology, when pregnant women have weak uterine contractions, slow progress of labor, or need to terminate pregnancy early, doctors will reasonably use oxytocin acetate to induce or accelerate labor according to the specific conditions of the pregnant woman and the fetus, strengthening uterine contractions and promoting the labor process. However, during use, the dosage and drip rate must be strictly controlled, and the conditions of the pregnant woman and the fetus must be closely monitored.
2. Prevention and Treatment of Postpartum Hemorrhage: Postpartum hemorrhage is a serious complication during childbirth. Oxytocin Acetate can reduce the risk of postpartum uterine bleeding by enhancing uterine contractility, which compresses the blood vessels in the uterine muscle layer, ensuring the safety of the parturient. Usually, a certain dose of oxytocin acetate is given to the parturient immediately after the fetus is delivered to prevent postpartum hemorrhage.
V. Precautions for Use
1. Strictly Follow Doctor's Advice: Oxytocin Acetate must be used under the guidance of a doctor. The doctor will accurately calculate the dosage and usage according to the patient's specific condition and physical condition. Patients must not increase or decrease the dosage or change the usage method by themselves.
2. Risk Assessment: A comprehensive risk assessment of the patient is required before use. For parturients with uterine-related diseases (such as scarred uterus, placenta previa, etc.), the use of oxytocin acetate may increase the risk of uterine rupture; excessive uterine contractions may cause intrauterine hypoxia of the fetus, leading to fetal distress. Therefore, during use, the uterine contraction of the pregnant woman and the changes in fetal heart rate must be closely monitored. If any abnormality occurs, corresponding measures should be taken immediately.
3. Not Suitable for All Populations: It is contraindicated for those allergic to oxytocin acetate; it is also contraindicated for patients with obvious cephalopelvic disproportion, abnormal fetal position, umbilical cord presentation or prolapse, placenta previa, fetal distress, excessive uterine contractions, etc. In addition, when pregnant women have heart disease, hypertension and other diseases, it needs to be used with caution and under enhanced monitoring.
VI. Storage Conditions
Oxytocin Acetate should be stored at -20℃ in a low-temperature environment, avoiding light and moisture to ensure the stability and activity of the product. During storage and transportation, the specified conditions must be strictly followed to prevent product deterioration.
As an important peptide hormone drug, Oxytocin Acetate is widely used in obstetrics and gynecology and related research fields, but it must be used cautiously in accordance with scientific methods and doctors' guidance.
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