99% High Purity USP Pharmacy Grade Levocetirizine Dihydrochloride With Fast Delivery

Levocetirizine dihydrochloride More Info

Levocetirizine dihydrochloride is a selective second-generation antihistamine and the active enantiomer of cetirizine, identified by the CAS Registry Number 130018-87-0. Its molecular structure is characterized by the R-enantiomer configuration, which is responsible for its potent pharmacological activity. The compound is formulated as a dihydrochloride salt to enhance its stability, crystallinity, and solubility for pharmaceutical development, typically appearing as a white to off-white powder.

The mechanism of action for this pharmaceutical involves potent and selective antagonism of the peripheral H1 histamine receptors. By competitively blocking the binding of histamine to these receptors, it effectively inhibits the cascade of inflammatory and allergic responses triggered by this mediator. Its high specificity for peripheral receptors, coupled with a low affinity for central nervous system receptors, results in powerful anti-allergic effects with a minimal propensity for causing sedation, a common limitation of first-generation antihistamines.

The primary clinical application of levocetirizine is the symptomatic relief of allergic conditions. It is extensively prescribed for the management of seasonal and perennial allergic rhinitis, providing relief from symptoms such as sneezing, rhinorrhea, and nasal itching. It is also highly effective in treating chronic idiopathic urticaria, reducing the occurrence and severity of hives and associated pruritus, thereby significantly improving patients' quality of life.

This medication is administered orally and is available in various formulations, including immediate-release and orally disintegrating tablets, as well as oral solutions for pediatric use. It demonstrates rapid absorption and a high bioavailability, with its peak plasma concentration achieved within a short time after ingestion. A key pharmacokinetic advantage is its low metabolic turnover, being predominantly excreted unchanged by the renal system, which minimizes the potential for drug-drug interactions mediated by hepatic enzymes.

The safety profile of levocetirizine is generally favorable and well-tolerated by most patients. The most commonly reported adverse effects are typically mild and may include headache, dry mouth, and occasional somnolence, though the incidence of sedation is notably lower than that associated with its racemic parent compound, cetirizine. Due to its renal pathway of elimination, dosage adjustment is recommended for patients with moderate to severe renal impairment to prevent potential accumulation and an increased risk of adverse effects.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

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Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
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Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
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We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
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Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.