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Propyl chloroformate CAS:109-61-5

Name: Propyl chloroformate CAS:109-61-5
Brand: Orient
SKU: pr2511261349
Price: 5 USD
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CAS No.:

109-61-5

Grade:

Industrail Grade

Content:

99%

Port:

SHANGHAI

Brand:

Orient

Packaging:

25L, 200L, 1000L, customized

Price valid (until):

2025-12-26

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

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Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information

Description

Propyl chloroformate Basic information

Product Name:	Propyl chloroformate
Synonyms:	Propyl chloroforMat;propyl carbonochloridate;Propyl chloroforMate, 98%+;Chloride propyl forMate;chlorocarbonicacidpropylester;chloro-formicacipropylester;Formic acid, chloro-, propyl ester;Propyl chloridocarbonate
CAS:	109-61-5
MF:	C4H7ClO2
MW:	122.55
EINECS:	203-687-7
Product Categories:	API Intermediate;Agrochemicals;CHLOROFORMATES;Acid HalidesDerivatization Reagents HPLC;Carbonyl Chlorides;Carbonyl Compounds;Fluorescence;Organic Building Blocks;bc0001;K00001
Mol File:	109-61-5.mol

Propyl chloroformate Chemical Properties

Boiling point	105-106 °C(lit.)
density	1.09 g/mL at 25 °C(lit.)
vapor pressure	0.87 psi ( 20 °C)
refractive index	n20/D 1.404(lit.)
Fp	84 °F
storage temp.	2-8°C
solubility	benzene: miscible(lit.)
form	Oil
color	Colourless
Specific Gravity	1.09
Merck	13,7940
Dielectric constant	11.2（20℃）
Stability:	Volatile
InChIKey	QQKDTTWZXHEGAQ-UHFFFAOYSA-N
LogP	1.385 (est)
CAS DataBase Reference	109-61-5(CAS DataBase Reference)
NIST Chemistry Reference	n-Propylchloroformate(109-61-5)
EPA Substance Registry System	Propyl chloroformate (109-61-5)

Safety Information

Hazard Codes	T,F
Risk Statements	10-23-34-22-11
Safety Statements	26-36-45-16
RIDADR	UN 2740 6.1/PG 1
WGK Germany	1
RTECS	LQ6830000
HazardClass	6.1(a)
PackingGroup	I
HS Code	29151300
Hazardous Substances Data	109-61-5(Hazardous Substances Data)
Toxicity	mouse,LC50,inhalation,319ppm/1H (319ppm),"Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson, M., and D. Eckroth, eds. New York, John Wiley & Sons, Inc., 1978Vol. 4, Pg. 758, 1978.

Propyl chloroformate Usage And Synthesis

Chemical Properties	Propyl Chloroformate (PCF) is a colorless to yellow liquid, with a pungent odor. It reacts with water and spontaneous decomposes. It is miscible with benzene and ether.
Uses	Propyl Chloroformate is used as a dramatizing agent for the determination of morphine, codeine and 6-acetyl morphine in urine and blood using direct aqueous derivatization.
Application	Propyl chloroformate has been used: as derivatization reagent in quantification of dopamine, serotonin and norepinephrine in human urine by solid phase microextraction-gas chromatography-triple quadrupole mass spectrometry in the preparation of dipropyl 3,6-diphenyl-1,2-dihydro-1,2,4,5-tetrazine-1,2-dicarboxylate N-propyl chloroformate is an intermediate of the fungicide propamocarb.
Preparation	Synthesis of Propyl chloroformate: Add n-propanol to the phosgene-passing kettle, start stirring, and then pass phosgene through the phosgene flowmeter. The phosgene-passing temperature is about 30 °C, and continue to pass the phosgene for several hours. When the end point is approached, sample and analyze, and stop when the standard is reached. Pass phosgene, cool, and then pass nitrogen to drive away phosgene and hydrogen chloride, destroy phosgene, and sample and analyze it as a product. Reaction equation: CH3CH2CH2OH+COCl2→ClCOOCH2CH2CH3
Production Methods	Prepared by the reaction of liquid anhydrous n-propyl alcohol with molar excess of dry, chlorine-free phosgene at low temperature.
General Description	N-propyl chloroformate appears as a colorless liquid. May be decomposed by water. Severely irritates skin and eyes. Very toxic by ingestion, inhalation or skin absorption. Denser than water and vapors heavier than air. Flash point 50°F. Used to make other chemicals.
Air & Water Reactions	Highly flammable. Water (moisture in air or soil) reacts with generation of heat and hydrochloric acid.
Reactivity Profile	Unstable, decomposes spontaneously to form hydrochloric acid and other products. Avoid moist air. [EPA, 1998]. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Health Hazard	Strongly irritating to eyes and mucous membranes. Poisonous; may be fatal if inhaled, swallowed or absorbed through skin.
Fire Hazard	When heated to decomposition, Propyl chloroformate emits toxic fumes of chlorine containing compounds. Propyl chloroformate is a flammable/combustible material; Propyl chloroformate may be ignited by heat, sparks or flames. Vapors may travel to a source of ignition and flash back. Container may explode in heat or fire. Vapor explosion and poison hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Runoff from fire control or dilution water may cause pollution. Gradually decomposed by water and alcohol. Unstable, decomposes spontaneously to form hydrochloric acid and other products. Avoid moist air.
Flammability and Explosibility	Flammable
Safety Profile	Poison by skin contact. Moderately toxic by ingestion and inhalation. A corrosive irritant to skin, eyes, and mucous membranes. Flammable when exposed to heat or flame, can react vigorously with oxidizing materials. When heated to decomposition it emits toxic fumes of Cl-. Used as a reactive intermediate to polymerization initiators.
Potential Exposure	Propyl chloroformate is used in organic synthesis; as an intermediate for polymerization initiators; may have been used as a military poison gas.
Shipping	UN2740 n-Propyl chloroformate, Hazard class: 6.1; Labels: 6.1-Poison Inhalation Hazard, 3-Flammable liquid, 8-Corrosive material. Inhalation Hazard Zone B
Incompatibilities	Propyl chloroformate forms explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explo- sions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, water and alcohols. Reaction with water forms heat and hydrochloric acid. Attacks some metals and coating in the presence of moisture.

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Certificates

Basic Info

Product Name:

Propyl chloroformate

Other Name:

Carbonochloridic acid,propyl ester;Formic acid,chloro-,propyl ester;Propyl chlorocarbonate;Propyl chloroformate;n-Propyl chloroformate;Propyl carbonochloridate;Chloroformic acid propyl ester;Chloroformic acid n-propyl ester

CAS No.:

109-61-5

Molecular Formula:

C4H7ClO2

InChIKeys:

InChIKey=QQKDTTWZXHEGAQ-UHFFFAOYSA-N

Molecular Weight:

122.550

Exact Mass:

122.55

EC Number:

203-687-7

UNII:

A5Y2T003JU

ICSC Number:

1595

UN Number:

2740

DSSTox ID:

DTXSID3042342

Color/Form:

COLORLESS LIQUID

HScode:

2915900090

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

26.30000

XLogP3:

1.97

Appearance:

N-propyl chloroformate appears as a colorless liquid. May be decomposed by water. Severely irritates skin and eyes. Very toxic by ingestion, inhalation or skin absorption. Denser than water and vapors heavier than air. Flash point 50°F. Used to make other chemicals.

Density:

1.091 g/cm³ @ Temp: 20 °C

Melting Point:

Boiling Point:

112.4 °C

Flash Point:

28.9±0.0 °C

Refractive Index:

1.412

Water Solubility:

Solubility in water: reaction

Storage Conditions:

OWING TO THE FACT THAT THESE COMPOUNDS DECOMP EASILY, STORAGE CONTAINERS SHOULD BE VENTED. /CHLOROFORMATES/

Vapor Pressure:

20 mm Hg @ 25.3 deg C

Vapor Density:

Relative vapour density (air = 1): 4.23

Experimental Properties:

GRADUALLY DECOMP IN WATER OR ALCOHOL|CONVERSION FACTOR: 5.00 MG/CU M= 1 PPM|Aqueous hydrolysis rate constant in distilled water is 0.0003922/sec at 24.8 °C which corresponds to a hydrolysis half-life of about 29.5 min|Flash point: 34.4 °C (Tag open cup)|For more Other Experimental Properties (Complete) data for N-PROPYL CHLOROFORMATE (6 total), please visit the HSDB record page.

Air and Water Reactions:

Highly flammable. Water (moisture in air or soil) reacts with generation of heat and hydrochloric acid.

Reactive Group:

Acyl Halides, Sulfonyl Halides, and Chloroformates

Reactivity Alerts:

Highly Flammable

Reactivity Profile:

Unstable, decomposes spontaneously to form hydrochloric acid and other products. Avoid moist air. [EPA, 1998]. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Autoignition Temperature:

475 °C

See More Propyl chloroformate Properties 

Hazard Identification

Classification of the substance or mixture

Flammable liquids, Category 2

Skin corrosion, Sub-category 1B

Acute toxicity - Category 3, Inhalation

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H225 Highly flammable liquid and vapour H314 Causes severe skin burns and eye damage H331 Toxic if inhaled
Prevention	P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P260 Do not breathe dust/fume/gas/mist/vapours/spray. P264 Wash ... thoroughly after handling. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse affected areas with water [or shower]. P370+P378 In case of fire: Use ... to extinguish. P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P363 Wash contaminated clothing before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P316 Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Storage	P403+P235 Store in a well-ventilated place. Keep cool. P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

NO open flames, NO sparks and NO smoking. Above 26Â°C use a closed system, ventilation and explosion-proof electrical equipment. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Fireproof. Provision to contain effluent from fire extinguishing. Separated from acids, alcohols, amines, bases, oxidants and food and feedstuffs. Dry. Well closed. Store in an area without drain or sewer access.OWING TO THE FACT THAT THESE COMPOUNDS DECOMP EASILY, STORAGE CONTAINERS SHOULD BE VENTED. CHLOROFORMATES

See More Propyl chloroformate Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221
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Propyl chloroformate CAS:109-61-5

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