 Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > Pyrrolidine for Sale > Pyrrolidine CAS:123-75-1

Pyrrolidine CAS:123-75-1 buy - large image1

Pyrrolidine CAS:123-75-1

Name: Pyrrolidine CAS:123-75-1
Brand: Orient
SKU: pr2511261480
Price: 10 USD
Availability: InStock

TDS 5 Inquiries

Unit Price: Get Latest Price 

CAS No.:

123-75-1

Grade:

Industrial Grade

Content:

99%

Port:

SHANGHAI

Brand:

Orient

Packaging:

25kg/bag,500kg/bag, customized

Price valid (until):

2025-12-26

Contact Supplier

 Chat Now

Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

 Visit Store

Product Description
Seller Information
Inquiry History

Description

Pyrrolidine Chemical Properties

Melting point	-63 °C
Boiling point	87-88 °C/760 mmHg (lit.)
density	0.852 g/mL at 25 °C (lit.)
vapor density	2.45 (vs air)
vapor pressure	128 mm Hg ( 39 °C)
refractive index	n20/D 1.443(lit.)
FEMA	3523 \| PYRROLIDINE
Fp	37 °F
storage temp.	Store below +30°C.
solubility	water: miscible
pka	11.27(at 25℃)
form	Liquid
color	Colorless to Almost colorless
Odor	at 0.10 % in propylene glycol. ammoniacal animal egg amine
PH	12.9 (100g/l, H2O, 20℃)
explosive limit	1.6-10.6%(V)
Odor Type	ammoniacal
biological source	synthetic
Water Solubility	Miscible with alcohol, ether, chloroform and water.
Sensitive	Air Sensitive
Merck	14,8015
JECFA Number	1609
BRN	102395
Dielectric constant	8.3000000000000007
Stability:	Stable; flammable. Incompatible with strong acids, strong oxidizing agents.
InChIKey	RWRDLPDLKQPQOW-UHFFFAOYSA-N
LogP	0.22 at 25℃
Surface tension	30.11mN/m at 293.15K
CAS DataBase Reference	123-75-1(CAS DataBase Reference)
NIST Chemistry Reference	Pyrrolidine(123-75-1)
EPA Substance Registry System	Pyrrolidine (123-75-1)

Pyrrolidine Usage And Synthesis

Chemical Properties	Pyrrolidine appears as a colorless to pale yellow liquid with an ammonia-like odor. It is infinitely miscible with water and conventional organic solvents such as methanol, acetone, ether, and chloroform. It acts as a lachrymator. Chemically, pyrrolidine behaves like a secondary amine in every respect. For example, it undergoes Leuckart –Wallach and Mannich reactions and is readily converted into an enamine. In the presence of a catalyst, such as platinum at 360°C or rhodium at 650°C, pyrrole is formed. In the presence of a copper catalyst, N-methylpyrrolidone is converted into N-methylpyrrolidine.
Physical properties	Pyrrolidine has a penetrating amine-type odor, reminiscent of ammonia and piperidine. It is easy to turn yellow when exposed to light or humid air, easily soluble in water and ethanol. It is nauseating and diffusive.
Occurrence	Reported found in beer, bread, wheat bread, salmon caviar, fish, milk, leaves and stalks of celery, Camembert cheese, Limburger cheese, Russian cheeses, tilsit cheese, other cheeses, caviar, raw fatty fish, beer, Finnish whiskey, white wine, red wine, coffee, radish, malt, roasted peanut, sweet corn and roasted barley.
Uses	Pyrrolidine is a flammable alkaline liquid that undergoes reactions typical of secondary amines. It is used to prepare pesticides and rubber accelerators and as a chemical intermediate (usually the hydrochloride form) in the pharmaceutical industry. There is relatively limited industrial exposure to this material.
Application	Pyrrolidine is a heterocyclic compound used as a building block in the synthesis of wide range of pharmaceutical compounds, namely matrix metalloprotein inhibitors (MMPIs) and aminopeptidase N inhibitors (APNIs). It has been used for the synthesis of N-benzoyl pyrrolidine from benzaldehyde via oxidative amination. It may be used as a catalyst for the synthesis of N-sulfinyl aldimines from carbonyl compounds and sulfonamides. Pyrrolidine can also be used to synthesize: Taddol-pyrrolidine phosphoramidite, a ligand for rhodium-catalyzed [2+2+2] cycloaddition of pentenyl isocyanate and 4- ethynylanisole. H,4 PyrrolidineQuin-BAM (′PBAM′), a selective catalyst for the aza-Henry addition of nitroalkanes to aryl aldimines. 1,2,3,3a,4,9-Hexahydropyrrolo[2,1-b]quinazoline by reacting with o-aminobenzaldehyde.
Preparation	Pyrrolidine is formed by reduction of pyrrole. Via overall 5-endo-trig cyclizations of homoallylic tosylamides. Pyrrolidine can be produced from butanediol and ammonia, e.g., over an aluminum thorium oxide catalyst at 300°C or over a nickel catalyst at 200°C and 20 MPa under hydrogenation conditions. It can also be produced from THF and ammonia over aluminum oxide at 275-375°C.
Definition	ChEBI: Pyrrolidine is a cyclic amine whose five-membered ring contains four carbon atoms and one nitrogen atom; the parent compound of the pyrrolidine family. It is a saturated organic heteromonocyclic parent, a member of pyrrolidines and an azacycloalkane. It is a conjugate base of a pyrrolidinium ion.

Shop Pyrrolidine CAS:123-75-1-Detailed Image 1

Shop Trimellitic Anhydride C9H4O5 552-30-7-Detailed Image 2

Shop Trimellitic Anhydride C9H4O5 552-30-7-Detailed Image 3

Shop Trimellitic Anhydride C9H4O5 552-30-7-Detailed Image 4

Shop Trimellitic Anhydride C9H4O5 552-30-7-Detailed Image 5

Shop Trimellitic Anhydride C9H4O5 552-30-7-Detailed Image 6

Shop Trimellitic Anhydride C9H4O5 552-30-7-Detailed Image 7

Shop Trimellitic Anhydride C9H4O5 552-30-7-Detailed Image 8

Shop Trimellitic Anhydride C9H4O5 552-30-7-Detailed Image 9

Shop Trimellitic Anhydride C9H4O5 552-30-7-Detailed Image 10

Shop Trimellitic Anhydride C9H4O5 552-30-7-Detailed Image 11

Shop Trimellitic Anhydride C9H4O5 552-30-7-Detailed Image 12

—— Q&A ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

ECHEMI Editorial Reference

COLOURLESS-TO-YELLOW LIQUID WITH PUNGENT ODOUR.

Certificates

Basic Info

Product Name:

Pyrrolidine

Other Name:

Pyrrolidine;Azacyclopentane;Prolamine;Pyrrole,tetrahydro-;Tetrahydropyrrole;Tetramethylenimine;Pyrrolidine ring;Butylenimine;Azolidine;Perhydropyrrole;NSC 62781;9: PN: WO2017048620 SEQID: 14 claimed sequence

CAS No.:

123-75-1

Molecular Formula:

C4H9N

InChIKeys:

InChIKey=RWRDLPDLKQPQOW-UHFFFAOYSA-N

Molecular Weight:

71.12

Exact Mass:

71.12

BRN:

102395

EC Number:

204-648-7

UNII:

LJU5627FYV

ICSC Number:

1315

NSC Number:

62781

UN Number:

1922

DSSTox ID:

DTXSID3059559

Color/Form:

Colorless to pale yellow liq

HScode:

2933990090

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

XLogP3:

0.46

Appearance:

Liquid

Density:

0.8520 g/cm³ @ Temp: 22.5 °C

Melting Point:

57.69 °C

Boiling Point:

86.71 °C

Flash Point:

37 °F

Refractive Index:

1.428

Water Solubility:

Miscible with alcohol, ether, chloroform and water.

Storage Conditions:

Flammables area

Vapor Pressure:

128 mm Hg ( 39 °C)

Vapor Density:

2.45 (vs air)

Toxicity:

Oral-Rat LD50: 300 mg/kg; Oral-Mouse LD50: 450 mg/kg

Flammability characteristics:

It is flammable in case of open flame, high temperature and oxidant; produces toxic nitrogen oxide gas when heated

Explosive limit:

1.6-10.6%(V)

Odor:

Unpleasant, ammoniacal odor

Taste:

POWERFUL, AMMONIACAL TASTE

Henrys Law Constant:

2.39e-06 atm-m3/mole|Henry's Law constant = 2.39X10-6 atm-cu m/mol at 25 dec C

Dissociation Constants:

pK at 25 °C = 2.89|pKa = 11.31

Experimental Properties:

Hydroxyl radical reaction rate constant = 7.85X10-11 cu cm/molec-sec at 25 °C (est)

Air and Water Reactions:

Highly flammable. Very soluble in water.

Reactive Group:

Amines, Phosphines, and Pyridines

Reactivity Alerts:

Highly Flammable

Reactivity Profile:

PYRROLIDINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. An explosion occurred when a mixture of pyrrolidine, benzaldehyde, and propionic acid was heated in an attempt to form porphyrins.

Heat of Combustion:

-673.75 Kcal/mol at 298 K and 1 atm

Flammable Limits:

LOWER: 2.9% @ -2 °C, UPPER 13.0% @ 29.8 °C

Physical Dangers:

The vapour is heavier than air and may travel along the ground; distant ignition possible.

Corrosivity:

Corrosive

Heat of Vaporization:

529 J/g at 0.1 MPa

Critical Temperature & Pressure:

Critical temperature: 568.55 K; Critical pressure: 5.6134X10+6 Pa

See More Pyrrolidine Properties 

Hazard Identification

Classification of the substance or mixture

Flammable liquids, Category 2

Acute toxicity - Category 4, Oral

Skin corrosion, Sub-category 1A

Serious eye damage, Category 1

Acute toxicity - Category 4, Inhalation

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H225 Highly flammable liquid and vapour H302 Harmful if swallowed H314 Causes severe skin burns and eye damage H332 Harmful if inhaled
Prevention	P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse affected areas with water [or shower]. P370+P378 In case of fire: Use ... to extinguish. P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P363 Wash contaminated clothing before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P316 Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P317 Get medical help.
Storage	P403+P235 Store in a well-ventilated place. Keep cool. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

NO open flames, NO sparks and NO smoking. Closed system, ventilation, explosion-proof electrical equipment and lighting. Use non-sparking handtools. Prevent build-up of electrostatic charges (e.g., by grounding). Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Fireproof. Separated from strong oxidants and acids. Well closed.Bundling and sills should be provided to prevent spread of liquid accidentally escaping from storage and process vessels.

See More Pyrrolidine Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

A reliable supplier is like insurance.

We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

5 Inquiries

Country	Product	Purchase Quantity	Date Posted
Poland	Pyrrolidine	20 MT	Mar 12, 2025
Singapore	Pyrrolidine	2 KG	Jul 22, 2026
Mexico	Tetrahydropyrrole	10 KG	Sep 30, 2023
Australia	pyrrolidine	1 KG	Mar 30, 2026
United Kingdom	Pyrrolidine	100 KG	Oct 14, 2024

Post an enquiry for this product

More Choices Find All Products for Sale 

Product Name	Grade / Content	Price	Supplier Name	Details
Pirrolidine colorless liquid cas 123-75-1 99.5%	Master /99.5		Heze Chenxiao Import and Export Trade Co. Ltd	Inquiry
Pyrrolidine	Different Grade/99.9	$0.1/KG EXW	Amitychem	Inquiry
Pyrrolidine 123-75-1	/		Shandong zhishang chemical Co.,Ltd	Inquiry
Pyrrolidine 99.0% Colourless clear liquid	Pharmaceutical Grade/99.0		Zhejiang Yuanjin Chemical Co., Ltd.	Inquiry
Pyrrolidine cas 123-75-1 99%	Pharmaceutical Grade/99		Wuhan TOPRAW Medicine Technology Cor,.Ltd	Inquiry

Hot Related Products



Feedback & Suggestions

Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.