Bestseller Desired product NAD NJ500 Safety-certified 99% purified

Sales manager:Lynn
whatsapp：+852 94453140
Email:Sales04@adsh.top

Company Introduction
Shanxi An Da Si Hai Technology Co., Ltd. is a professional manufacturer of various peptide products and chemical raw materials.
We have a dedicated R&D team and a reliable, efficient logistics team to ensure you receive high-quality products safely and promptly. Our customers come from countries including the United States, Europe,
Europe, Japan, South Korea, and India. Most of our main products are in stock and ready for immediate shipment. Please let us know the specific quantity you need, and we will offer you the most competitive price. Feel free to contact us for more information.

We offer various types of peptides，are widely used in life science research, drug discovery, cosmetics, anti-aging medicine, and functional health industries.about the peptides，we can provide the good quality，the good price.Customers who have ordered our products（peptides）have had very good feedback.
World wide relaible buyers can contact us about the peptides.

1. Superior Product Quality

Product quality is the foundation of our business. Peptides are synthesized using solid-phase peptide synthesis (SPPS), then purified through HPLC and confirmed by mass spectrometry (MS).

Each batch includes a Certificate of Analysis (COA) with key data:
• Purity (HPLC)
• Molecular weight (MS)
• Water content
• Residual solvents
• Microbial limit (if applicable)

For clients with higher regulatory demands, we also provide third-party testing reports, endotoxin (LAL) data, and stability studies upon request.

2. Customization & R&D Support

We offer flexible custom synthesis services, supported by an experienced R&D team. Whether you’re looking for novel peptide sequences, cosmetic-grade purity, or modified molecules (e.g., PEGylation, acetylation), we can deliver high-quality results on time.

Our services include:
• Custom peptide synthesis (mg to kg scale)
• Peptide modifications and labeling
• Small molecule synthesis
• Project-based research and scale-up

We work closely with our clients to ensure technical feasibility, fast delivery, and cost control throughout the development cycle.

3. Wide Product Portfolio

We supply a comprehensive and expanding product range:
• Peptides: GLP-1 analogs (e.g., Semaglutide, Tirzepatide, Retatrutide), cosmetic peptides (e.g., Acetyl Hexapeptide-8, Matrixyl), anti-aging peptides, research peptides.
• Small Molecules: Nootropics, NAD+ boosters (e.g., NMN, NR, NADH), and intermediates.
• Biochemicals: Amino acid derivatives, enzyme co-factors, custom reagents.

New products are launched regularly to meet evolving market needs. We also support batch reservations for clients with ongoing or seasonal demand.

β-Nicotinamide adenine dinucleotide More Info

β-Nicotinamide adenine dinucleotide, commonly known as NAD+, is a vital coenzyme found in all living cells that plays a central role in metabolism and cellular physiology. It is a dinucleotide composed of two nucleotides joined through their phosphate groups: one containing an adenine base and the other nicotinamide.

Mechanism of Action

NAD+ primarily functions as an essential coenzyme in redox reactions, acting as an electron carrier. It cycles between an oxidized form (NAD+) and a reduced form (NADH):
Redox Reactions: NAD+ accepts electrons (in the form of a hydride ion) from metabolic substrates during processes like glycolysis, the tricarboxylic acid (TCA) cycle, fatty acid oxidation, and oxidative phosphorylation. This electron transfer is crucial for ATP production and energy metabolism.
Enzymatic Cofactor: NAD+ serves as a cofactor for various dehydrogenase enzymes, facilitating oxidation-reduction reactions essential for cellular respiration and biosynthesis.
Substrate for NAD+-Dependent Enzymes: Beyond redox roles, NAD+ is a substrate for enzymes involved in post-translational modifications, including sirtuins (protein deacetylases), poly(ADP-ribose) polymerases (PARPs), and ADP-ribosyl cyclases, which regulate DNA repair, gene expression, and calcium signaling.
RNA Capping: NAD+ can be incorporated as a non-canonical cap at the 5′ end of RNA transcripts, influencing RNA stability and gene expression regulation.

Biosynthesis and Metabolism

NAD+ levels in cells are maintained through multiple pathways:
De Novo Synthesis: NAD+ can be synthesized from dietary amino acids like tryptophan via the kynurenine pathway.
Preiss-Handler Pathway: Converts dietary nicotinic acid (NA) into NAD+ through intermediate steps.
Salvage Pathway: The predominant pathway in most cells, recycling nicotinamide (NAM), nicotinamide riboside (NR), and nicotinamide mononucleotide (NMN) back into NAD+ to maintain cellular levels. The rate-limiting enzyme in this pathway is nicotinamide phosphoribosyltransferase (NAMPT).
Methylation and Excretion: Excess NAM is methylated by nicotinamide N-methyltransferase (NNMT) and ultimately excreted, regulating NAD+ homeostasis.

Physiological Roles

Energy Metabolism: NAD+ is indispensable for glycolysis, TCA cycle, and oxidative phosphorylation, enabling efficient ATP production.
Redox Homeostasis: Maintains cellular redox balance by cycling between NAD+ and NADH.
DNA Repair and Genomic Stability: Serves as a substrate for PARPs involved in DNA repair mechanisms.
Regulation of Gene Expression: Through sirtuins, NAD+ influences chromatin remodeling and transcriptional regulation.
Immune Response and Inflammation: Modulates immune cell function and inflammatory processes.
Circadian Rhythm: NAD+ levels influence circadian clock regulation via sirtuin activity.
Aging and Disease: Dysregulation or depletion of NAD+ is linked to aging, metabolic disorders, neurodegeneration, cancer, and cardiovascular diseases.

Pharmacokinetics and Cellular Distribution

NAD+ is compartmentalized within cells in the cytoplasm, mitochondria, and nucleus, with distinct pools regulated independently.
It is synthesized and recycled intracellularly, with limited direct uptake from extracellular sources. Oral NAD+ precursors like NR and NMN are metabolized to NAM before contributing to NAD+ pools.
NAD+ has a relatively short half-life and is rapidly turned over due to its consumption by NAD+-dependent enzymes.

Q1:Are you a supplier or a manufacturer?
A:We are both a supplier and a manufacturer.

Q2:How will you deliver the goods?
A:We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS, China Air Post. For container products, we can do sea shipping. You also can choose your own shipping forwarder.

Q3:Which kind of payment terms do you accept?
A:, Bitcoin, PayPal.USDT.

Q4:How is the after-sales service?
A:We will provide high-quality products and ensure 100% safe deliver.

Q5:how can we guarantee quality?
A:We will send you a COA (Certificate of Analysis) to you first for you to confirm the quality.

Q6: How to confirm the Product Quality before placing orders?
A:You can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

Q7:Is there any discount?
A:Yes, for larger quantity, we always support with better price.

Welcome to be our distinguished customer,Become our valued and esteemed partner!

From the moment you choose us, we integrate our "customer-centric" service philosophy into every aspect – you will enjoy a dedicated service team providing a priority channel for your needs. Whether it's product usage guidance, customized product adjustments, or after-sales support, we will ensure a smooth and worry-free experience with our SLA service commitment standards (response time ≤ 2 hours, problem resolution cycle ≤ 48 hours).

At the same time, we will regularly update you on product updates and exclusive benefits (such as priority access to new products and customized service discounts), and continuously optimize our service processes based on your feedback, striving to ensure that every collaboration meets your expectations. Thank you again for your trust and choice. We look forward to a long-term partnership with you!

please do not hesitate to contact me!