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N-Acetylneuraminic acid 131-48-6

Name: N-Acetylneuraminic acid 131-48-6
Brand: Orient
SKU: pr2512181121
Price: 4 USD
Availability: InStock

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CAS No.:

131-48-6

Grade:

Industrail Grade

Content:

99%

Port:

shnaghai

Brand:

Orient

Packaging:

25L, 200L, 1000L, customized

Price valid (until):

2026-01-18

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Product Name:	N-Acetylneuraminic acid
Synonyms:	5-(acetylamino)-3,5-dideoxy-d-glycero-d-galacto-2-nonulosonicaci;LACTAMINIC ACID;5-ACETAMIDO-3,5-DIDEOXY-D-GLYCERO-D-GALACTO-2-NONU;5-ACETAMIDO-3,5-DIDEOXY-D-GLYCERO-D-GALACTO-2-NONULOSONIC ACID;5-ACETAMIDO-3,5-DIDEOXY-D-GLYCERO-D-GALACTO-NONULOPYRANOSONIC ACID HYDRATE;5-ACETAMIDO-3,5-DIDEOXY-D-GLYCERO-D-GALACTONONULOSONIC ACID;5-ACETAMIDO-3,5-DIDEOXY-D-GLYCERO-D-GALACTONULOSONIC ACID;5-ACETYLAMINO-3,5-DIDEOXY-D-GLYCERO-D-GALACTO-2-NONULOSONIC ACID
CAS:	131-48-6
MF:	C11H19NO9
MW:	309.27
EINECS:	205-023-1
Product Categories:	Bioproducts;Sugar derivatives;13C & 2H Sugars;Sialic Acids;Biochemistry;Carbohydrates & Derivatives;Miscellaneous Natural Products;Zanamavir;Sugar Acids;Sugars;Miscellaneous Compounds;carbohydrate;API;131-48-6
Mol File:	131-48-6.mol

N-Acetylneuraminic acid Chemical Properties

Melting point	184-186 °C
alpha	-32 º (c=2,water)
Boiling point	449.56°C (rough estimate)
density	1.3580 (rough estimate)
refractive index	-32 ° (C=1, H2O)
storage temp.	-20°C
solubility	50 g/L (20°C)
pka	2.41±0.54(Predicted)
form	synthetic, crystalline
color	White to Off-White
biological source	synthetic
Optical Rotation	-32
Water Solubility	50 g/L (20 ºC)
Sensitive	Air Sensitive
Merck	14,8484
BRN	1716283
Stability:	Stable. Incompatible with strong oxidizing agents.
Cosmetics Ingredients Functions	SKIN CONDITIONING SKIN PROTECTING
InChIKey	SQVRNKJHWKZAKO-PFQGKNLYSA-N
LogP	-1.897 (est)
CAS DataBase Reference	131-48-6(CAS DataBase Reference)
EPA Substance Registry System	Neuraminic acid, N-acetyl- (131-48-6)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	22-24/25-36-26
WGK Germany	3
F	3-10-23
Hazard Note	Irritant
TSCA	Yes
HS Code	29329970

MSDS Information

N-Acetylneuraminic acid Usage And Synthesis

Description	N-acetylneuraminic acid is an N-acyl derivative of neuraminic or acid amino sugar derivative, derived from N-acetylmannosamine and pyruvic acid. It is an important constituent of glycoproteins and glycolipids. N-acetylneuraminic acid occurs in many polysaccharides, glycoproteins, and glycolipids in animals and bacteria.
Physical properties	The numbering of the sialic acid structure begins at the carboxylate carbon and continues around the chain. The configuration which places the carboxylate in the axial position is the alpha-anomer. The alpha-anomer is the form that is found when sialic acid is bound to glycans, however, in solution it is mainly (over 90 %) in the beta-anomeric form. A bacterial enzyme with sialic acid mutarotase activity, NanM, has been discovered which is able to rapidly equilibrate solutions of sialic acid to the resting equilibrium position of around 90 % beta 10 % alpha.
Uses	N-Acetylneuraminic acid is an integral part of sialic acids (SAs), important functional sugars that play an important role in maintaining and improving brain health, detoxification, antibacterial, and immune enhancement. n-Acetylneuraminic acid is biologically useful for neurotransmission, leukocyte extravasation, viral or bacterial infection, and carbohydrate-protein recognition. n- Acetylneuraminic acid is used to study its biochemistry, metabolism and absorption in vivo and in vitro.
Definition	ChEBI: N-Acetylneuraminic acid is n-Acetylneuraminic acid with beta configuration at the anomeric centre. It has a role as an epitope. It is functionally related to a beta-neuraminic acid. It is a conjugate acid of a N-acetyl-beta-neuraminate.
Biosynthesis	In bacterial systems, sialic acids are biosynthesized by an aldolase enzyme. The enzyme uses a mannose derivative as a substrate, inserting three carbons from pyruvate into the resulting sialic acid structure. These enzymes can be used for chemoenzymatic synthesis of sialic acid derivatives.
Biological Functions	Sialic acid-rich glycoproteins (sialoglycoproteins) bind selectin in humans and other organisms. Metastatic cancer cells often express a high density of sialic acid-rich glycoproteins. This overexpression of sialic acid on surfaces creates a negative charge on cell membranes. This creates repulsion between cells (cell opposition) and helps these late-stage cancer cells enter the blood stream. Sialic acid also plays an important role in human influenza infections. Many bacteria also use sialic acid in their biology, although this is usually limited to bacteria that live in association with higher animals (deuterostomes). Many of these incorporate sialic acid into cell surface features like their lipopolysaccharide and capsule, which helps them evade the innate immune response of the host.[6] Other bacteria simply use sialic acid as a good nutrient source, as it contains both carbon and nitrogen and can be converted to fructose-6- phosphate, which can then enter central metabolism. Sialic acid-rich oligo saccharides on the glyco conjugates ( glyco lipids, glyco proteins, proteoglycans) found on surface membranes help keep water at the surface of cells . The sialic acid - rich regions contribute to creating a negative charge on the cells' surfaces. Since water is a polar molecule with partial positive charges on both hydrogen atoms, it is attracted to cell surfaces and membranes. This also contributes to cellular fluid uptake. Sialic acid can "hide" mannose antigens on the surface of host cells or bacteria from mannose - binding lectin . This prevents activation of complement. Sialic acid in the form of poly sialic acid is an unusual posttranslational modification that occurs on the neural cell adhesion molecules (NCAMs). In the synapse, the strong negative charge of the polysialic acid prevents NCAM cross-linking of cells.

First aid measures

If inhaled

Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

Following skin contact

Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

Following eye contact

Rinse with pure water for at least 15 minutes. Consult a doctor.

Following ingestion

Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

Accidental release measures

Personal precautions, protective equipment and emergency procedures

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak. Environmental precautions

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up

Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.

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—— Q&A ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

Q4:What if there are quality issues？

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Certificates

Basic Info

Product Name:

Acetylneuraminic acid

Other Name:

Neuraminic acid,N-acetyl-;D-glycero-D-galacto-Nonulosonic acid,5-acetamido-3,5-dideoxy-;Lactaminic acid;D-glycero-D-galacto-2-Nonulosonic acid,5-(acetylamino)-3,5-dideoxy-;N-Acetylneuraminic acid;Acetylneuraminic acid;NANA;N-Acetyl-D-neuraminic acid;5-N-Acetyl-D-neuraminic acid;Aceneuramic acid;N-Acetylneuramic acid;N-Acetylsialic acid;5-N-Acetylneuraminic acid;UX 001;5977-25-3;6225-16-7;6918-20-3;11032-36-3;14752-56-8;688025-48-1;801157-24-4;1195276-57-3;1195521-74-4

CAS No.:

131-48-6

Molecular Formula:

C11H19NO9

InChIKeys:

InChIKey=KBGAYAKRZNYFFG-BOHATCBPSA-N

Molecular Weight:

309.27

Exact Mass:

309.27

BRN:

1716283

EC Number:

205-023-1

UNII:

GZP2782OP0

HScode:

29329970

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

177

XLogP3:

-3.48090

Appearance:

synthetic, crystalline

Density:

1.3580 (rough estimate)

Melting Point:

182-185 °C (decomp)

Boiling Point:

449.56°C (rough estimate)

Flash Point:

414.8±32.9 °C

Refractive Index:

-32 ° (C=1, H2O)

Water Solubility:

H2O: 50 g/L (20 ºC)

Storage Conditions:

−20°C

Vapor Pressure:

5.5E-30mmHg at 25°C

Specific rotation:

-32 º (c=2,water)

See More Acetylneuraminic acid Properties 

Hazard Identification

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	none
Prevention	none
Response	none
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Acetylneuraminic acid Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

A reliable supplier is like insurance.

We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

3 Inquiries

Country	Product	Purchase Quantity	Date Posted
Australia	Sialic Acid N-Acetylneuraminic Acid 99.9% White Powder 131-48-6 Quanjinci	10	Oct 3, 2023
Vietnam	Acetylneuramic Acid	2 KG	Aug 27, 2025
Bangladesh	Butyl Acetate	1.00 KG	Nov 11, 2025

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