1. Description
Chemical properties: SNAP-8 belongs to the linear octapeptide compound, with an amino acid sequence of Ac Glu Gln Pro Gln Leu Gln Leu Leu OH. The N-terminus is acetylated to enhance lipid solubility and resistance to enzymatic hydrolysis. Its core target is the SNARE complex at the neuromuscular junction, which is a key protein responsible for neurotransmitter release. The chemical properties are stable and not easily hydrolyzed in neutral to weakly acidic (pH 5.5-7.5) environments. Its ability to resist skin protease degradation is superior to short chain peptides, and it has good compatibility with beauty active ingredients such as hyaluronic acid, ceramides, and vitamin C derivatives. Its molecular weight is 891.0 Da
Physical properties: SNAP-8 is a white to off white crystalline powder at room temperature, odorless and tasteless, with both water solubility and fat solubility (solubility ≥ 40 mg/mL, soluble in water, glycerol, propylene glycol, and low concentration ethanol). After dissolution, it appears as a colorless and transparent liquid without precipitation or turbidity. Store under dry, sealed, and dark conditions at -20 ℃ to avoid repeated freezing and thawing; Research grade/application grade products have a purity of ≥ 98% (detected by HPLC), a single impurity of ≤ 1.0%, no residual endotoxins (≤ 0.05 EU/mg), heavy metals (lead, mercury, arsenic, etc. ≤ 0.1 ppm), and meet the standards of high-end beauty raw materials.
Source and preparation: SNAP-8 has no natural form and is precisely prepared by solid-phase peptide synthesis method - using high-purity L-type amino acids as raw materials, condensation, deprotection, acetylation modification, peptide chain assembly, and finally purified by high performance liquid chromatography (HPLC) to obtain high-purity products; The synthesis process strictly controls the reaction conditions to ensure the integrity of the peptide chain structure and biological activity. The product quality is verified through mass spectrometry (MS) and amino acid sequence analysis, with no residual chemical synthesis by-products.
2. Application
Dynamic texture improvement products: SNAP-8 is suitable for 25+young and old muscles to 45+mature muscles. It is used to develop anti wrinkle essence, firming liquid, botulinum like essence, etc. for dynamic wrinkles (expression lines) such as forehead lifting, eyebrow lines, crow's feet lines, decree lines, etc; Compound logic: SNAP-8 (added at a concentration of 0.05% -0.2%)+Acetyl Hexapeptide-8 (0.02% -0.05%)+Recombinant Collagen (0.05% -0.1%). SNAP-8 targets the inhibition of dynamic lines, Acetyl Hexapeptide-8 enhances the effect of lightening lines, and Recombinant Collagen fills static lines, achieving a dual improvement of "dynamic lines+static lines".
Special anti wrinkle products around the eyes: SNAP-8 is used to prepare anti wrinkle eye cream and anti wrinkle essence around the eyes for people with crow's feet lines around the eyes, fine lines under the eyes and head lifting lines; Formula design: SNAP-8 (0.03% -0.1%)+caffeine (0.5% -1%)+hyaluronic acid microspheres (0.3% -0.5%). SNAP-8 attenuates dynamic lines around the eyes, caffeine relieves swelling, and hyaluronic acid microspheres instantly fill dry lines, suitable for fragile skin around the eyes.
Medical art post repair and anti-aging products: SNAP-8 is used to develop repair and anti-aging essence and firming facial mask after it is adapted to medical beauty projects such as Thermo Maggie and Photorejuvenation; Compound logic: SNAP-8 (0.05% -0.1%)+Ecrotoxin (1% -2%)+Pantone (2% -3%). SNAP-8 repairs the barrier while preventing dynamic wrinkle deepening. Ecrotoxin relieves postoperative irritation, while Pantone replenishes and repairs, enhancing the anti-aging and endurance effects of medical aesthetics.
Full face firming and anti-aging products: SNAP-8 is used to develop firming face cream, anti-aging second throw, neck cream, etc., to meet the needs of full face anti-aging; Compound logic: SNAP-8 (0.05% -0.15%)+Bose (3% -5%)+ceramide (0.2% -0.3%), SNAP-8 inhibits wrinkles caused by muscle contraction, Bose strengthens dermal support, ceramide repairs barriers, and realizes the synergy of "firming+light lines+anti-aging".
Body anti wrinkle care products: SNAP-8 is used to develop neck cream and body anti wrinkle lotion for neck lines, head lifting lines and hand fine lines; The added concentration is 0.05% -0.1%, compound supporting role squalane (2% -3%)+vitamin E (0.5% -1%), which can mildly remove wrinkles and moisturize the skin, suitable for anti-aging in dry parts of the body.
3. Main Efficacy
Targeted pale lines (botulinum toxin like) core efficacy: The SNAP-8 core mechanism simulates the principle of action of botulinum toxin, but has no toxicity - it specifically binds to the SNARE complex at the neuromuscular junction, preventing acetylcholine (neurotransmitter) from being released from the presynaptic membrane, inhibiting excessive muscle contraction, and reducing the production and deepening of dynamic lines (expression lines); The effect of reducing forehead wrinkles and crow's feet is significant. After continuous use for 28 days, the depth of dynamic wrinkles is reduced by 18% -25%, which is close to the effect of low concentration botulinum toxin, but does not require injection and has no risk of skin damage.
Tightening, anti-aging, and collagen regeneration effects: SNAP-8 not only inhibits dynamic wrinkles, but also stimulates the activity of skin fibroblasts, promotes the synthesis of type I and III collagen and elastic fibers, enhances skin tightness and elasticity, and improves nasolabial folds and blurred jawline caused by skin laxity; At the same time, it enhances the moisture content of the stratum corneum of the skin, reduces dry lines, and makes the skin more elastic, smooth, and delicate.
Mild hypoallergenic and long-lasting anti-aging effects: SNAP-8, as a small molecule octapeptide, has no toxicity or allergenicity of botulinum toxin, and does not affect normal physiological functions of muscles (such as chewing and facial expression naturalness). It only targets and inhibits excessive muscle contractions; According to the Skin Irritation Test (HRIPT), there is no sensitization, and the Cell Toxicity Test (MTT) shows that the skin cell survival rate is greater than 98% when the concentration is ≤ 0.5%. It is suitable for all skin types such as sensitive skin and pregnant women's skin, and long-term use has no dependence or side effects such as skin atrophy.
High penetration and synergistic advantages of compounding: Acetylation modification enhances the lipophilicity of SNAP-8, which can quickly penetrate the stratum corneum of the skin and reach the junction between the dermis layer and the neuromuscular junction. The transdermal absorption rate is 2-3 times higher than that of ordinary anti wrinkle peptides; When combined with other anti-aging ingredients such as peptides, hyaluronic acid, collagen, etc., there are no contraindications. It can synergistically enhance the effect of reducing wrinkles and tightening, and is suitable for various anti-aging formula designs
