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Tetrazole 288-94-8

Name: Tetrazole 288-94-8
Brand: Orient
SKU: pr2512291203
Price: 4 USD
Availability: InStock

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CAS No.:

288-94-8

Grade:

Industrail Grade

Content:

99%

Port:

shanghai

Brand:

Orient

Packaging:

25L, 200L, 1000L, customized

Price valid (until):

2026-01-29

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Product Name:	Tetrazole
Synonyms:	TETRAZOLE;1H-TETRAZOLE;1H-1,2,3,4-TETRAZOLE;1H-1,2,3,4-TETRAAZOLE;2H-TETRAZOLE;Tetrazole, 3 to 4 wt.% solution in acetonitrile, AcroSeal;Tetrazole 1H-Tetrazole;1H-Tetrazole [Coupling Agent]
CAS:	288-94-8
MF:	CH2N4
MW:	70.05
EINECS:	206-023-4
Product Categories:	Chemistry;Tetrazoles;Other Reagents;Peptide Synthesis;Solvents and Mixtures for Peptide Synthesis;Specialty Synthesis;Biotech SolventsSolvents;Solvent Bottles;Solvents;Sure/Seal? Bottles;1
Mol File:	288-94-8.mol

Tetrazole Chemical Properties

Melting point	156-158°C
Boiling point	220℃
density	0.798 g/mL at 20 °C
refractive index	n20/D 1.348
RTECS	UW7370000
Fp	5 °C
storage temp.	Room temperature.
solubility	DMSO, Methanol
form	Liquid
pka	4.9(at 25℃)
color	Cream to orange
Water Solubility	Soluble
Decomposition	220°C
BRN	105799
Stability:	Stable at RT
InChIKey	KJUGUADJHNHALS-UHFFFAOYSA-N
CAS DataBase Reference	288-94-8(CAS DataBase Reference)
NIST Chemistry Reference	1H-Tetrazole(288-94-8)
EPA Substance Registry System	1H-Tetrazole (288-94-8)

Safety Information

Hazard Codes	F,Xn,E
Risk Statements	11-20/21/22-36-5-4
Safety Statements	16-26-36-36/37-35-15
RIDADR	UN 1993 3/PG 2
WGK Germany	3
F	3-4.15-10
HazardClass	4.1
PackingGroup	III
HS Code	29339900

MSDS Information

Tetrazole Usage And Synthesis

Description	Tetrazole is a class of synthetic organic heterocyclic compound containing a 5-member ring of four nitrogen atoms and one carbon atom. It appears as an odorless white to light-yellow crystalline powder. It has several pharmaceutical applications. Tetrazole compound can act as a bioisotere for the carboxylate group, angiotensin II receptor blockers such as losartan and candesartan as well as dimethyl thiazolyl diphenyl tetrazolium bromide (MTT), which can be used in MTT assay for quantifying the respiratory activity of liver cells. It can also be used in DNA assays. In addition, Tetrazole derivatives have also been used in explosives such as TNT or high performance solid rocket propellant formulations. Tetrazole can be synthesized through the reaction between anhydrous hydrazoic acid and hydrogen cyanide under pressure.
References	https://en.wikipedia.org/wiki/Tetrazole https://pubchem.ncbi.nlm.nih.gov/compound/1H-Tetrazole#section=Information-Sources
Chemical Properties	white crystals or crystalline powder
Uses	Tetrazole is a catalyst for phosphoramidite synthesis. It is also used as an intermediate for the drug cilostazol. Cilostazol is an antiplatelet drug and a vasodilator. Tetrazole derivatives are used as antibiotics and optically active tetrazole-containing antifungal preparations of azole type was reported.
Application	1H-Tetrazole is used as a bioisostere for the carboxylate group. It is also used as coupling reagent for preparation of polynucleotides.
Preparation	The first tetrazole synthesis was reported in 1885. Tetrazole Synthesis: Nano-TiCl4.SiO2 (0.1 g) was added to a mixture of benzonitrile (1 mmol), sodium azide (2 mmol) in DMF (5 mL) at reflux for 2 h. After completion of reaction (as monitored by TLC), the mixture was allowed to cool to room temperature, the catalyst was removed by filtration. Then by adding ice water and 4N HCl (5 mL) to the residue, a white solid was obtained. This was then washed with cold chloroform. This simple procedure yielded pure tetrazole with good yields.

First aid measures

If inhaled

Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

Following skin contact

Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

Following eye contact

Rinse with pure water for at least 15 minutes. Consult a doctor.

Following ingestion

Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

Accidental release measures

Personal precautions, protective equipment and emergency procedures

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak. Environmental precautions

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up

Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.

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—— Q&A ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

Q4:What if there are quality issues？

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Certificates

Basic Info

Product Name:

1H-Tetrazole

Other Name:

2H-Tetrazole;1H-Tetrazole;Tetraazacyclopentadiene;NSC 36712;2,3,4-Triazapyrrole;1H-TZ;116421-33-1;288-95-9;6573-80-4;51852-99-4;100043-29-6

CAS No.:

288-94-8

Molecular Formula:

CH2N4

InChIKeys:

InChIKey=KJUGUADJHNHALS-UHFFFAOYSA-N

Molecular Weight:

70.05

Exact Mass:

70.05

EC Number:

206-023-4

NSC Number:

36712

UN Number:

0504

DSSTox ID:

DTXSID5075280

HScode:

2933990090

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

54.5

XLogP3:

-1.16

Appearance:

Cream to orange Liquid

Density:

1.5±0.1 g/cm3

Melting Point:

157 °C

Boiling Point:

220℃

Flash Point:

5 °C

Refractive Index:

1.543

Water Solubility:

H2O: soluble

Storage Conditions:

Room temperature.

Vapor Pressure:

394mmHg at 25°C

Air and Water Reactions:

Soluble in water (23 g/100 mL at 20°C) Reacts slowly with water (moisture) with release of corrosive gases (ammonia, nitrogen oxides).

Reactive Group:

Amines, Phosphines, and Pyridines

Reactivity Alerts:

Explosive

Reactivity Profile:

1-H-TETRAZOLE is stable at normal temperature and pressure but decomposes rapidly and explosively if heated above its melting point of 155-157° C (Chem. Rev 1947, 41, 5). Presents an extreme risk of explosion by shock, friction, fire or other sources of ignition. Reacts violently with strong oxidizers. Reacts with acidic materials (strong acids, acid anhydrides and acid chlorides) to release heat and toxic and corrosive gases. Reacts with some active metals to give new materials that are shock-sensitive explosives. Can react exothermically with reducing agents. Heating or burning releases toxic and corrosive nitrogen oxides, carbon monoxide, carbon dioxide. [MSDS Document number : 4330220A] Soluble in water. Soluble in acetonitrile. Dilute solutions (2-3% by mass) of 1-H-TETRAZOLE in acetonitrile are used in biochemistry for DNA synthesis.

See More 1H-Tetrazole Properties 

Hazard Identification

Classification of the substance or mixture

Explosives, Division 1.1

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H201 Explosive; mass explosion hazard
Prevention	P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P230 Keep wetted with ... P234 Keep only in original packaging. P240 Ground and bond container and receiving equipment. P250 Do not subject to grinding/shock/friction/â¦. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response	P370+P372+P380+P373 In case of fire: Explosion risk. Evacuate area. DO NOT fight fire when fire reaches explosives.
Storage	P401 Store in accordance withâ¦
Disposal	P503 Refer to manufacturer/supplierâ¦ for information on disposal/recovery/recycling.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More 1H-Tetrazole Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

A reliable supplier is like insurance.

We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
Canada	!H-Tetrazole	1 G	Feb 29, 2024

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