L-Valine CAS No.: 72-18-4 purity:98%

L-Valine More Info

L-Valine is one of the 20 proteinogenic amino acids and is classified as an essential amino acid. It is also one of the three Branched-Chain Amino Acids (BCAAs), along with L-Leucine and L-Isoleucine.

Because it is "essential," the human body cannot synthesize it on its own; therefore, it must be obtained through diet or supplementation.

1. Chemical Structure & Properties

Formula: C5​H11​NO2​

Structure: It is a non-polar, aliphatic amino acid. Its "branched-chain" structure (an isopropyl group side chain) is key to its metabolic pathway and biological activity.

Isomer: While the body can technically use D-Valine, the L-isomer (L-Valine) is the form naturally found in proteins and used by the body for protein synthesis.

2. Key Functions & Benefits

L-Valine plays several critical roles in human health and physiology:

Muscle Growth and Repair:As a BCAA, L-Valine stimulates muscle protein synthesis. It helps repair muscle tissue after intense exercise and reduces muscle breakdown (catabolism). It is particularly important for preventing muscle wasting in the elderly or during recovery from illness.

Energy Production:Unlike most amino acids, which are metabolized in the liver, BCAAs are metabolized directly in the muscles. L-Valine can be used as an energy source during prolonged exercise or when blood sugar levels are low.

Nitro Balance:It helps maintain a positive nitro balance in the body, which is essential for muscle retention and overall health.

Immune System Support:Valine is necessary for the production of antibodies and immunoglobulins, playing a role in maintaining a healthy immune response.

Mental Focus:Some studies suggest that Valine helps regulate the central nervous system and may improve cognitive function and focus, though it is less studied in this area than its BCAA counterparts.

3. Dietary Sources

L-Valine is abundant in many protein-rich foods. The best sources include:

Animal Products: Meat (beef, lamb, pork), poultry, fish, eggs, and dairy products (milk, cheese, yogurt).

Plant Sources: Soybeans, lentils, peanuts, and other legumes.

Grains: Whole grains like wheat and rice contain moderate amounts.

4. Industrial and Medical Applications

Sports Nutrition: It is a common ingredient in pre-workout and post-workout supplements (often in a 2:1:1 ratio with Leucine and Isoleucine) to aid recovery.

Medicine: It is used in intravenous (IV) solutions for patients who cannot eat (parenteral nutrition) to prevent muscle loss and maintain  balance.

Flavor Enhancer: Valine has a slightly bitter taste and is sometimes used in the food industry to enhance flavor.

5. Deficiency and Excess

Deficiency: Since Valine is common in most diets, deficiency is rare but can occur in those with severe malnutrition. Symptoms include muscle weakness, skin rashes, fatigue, and irritability.

Excess: High doses of isolated Valine (without balancing other BCAAs) can lead to neurological side effects or interfere with the absorption of other amino acids.

Summary

L-Valine is a cornerstone of muscle health and energy metabolism. As an essential BCAA, it is indispensable for athletes, bodybuilders, and anyone looking to maintain muscle mass and overall vitality.