High Purity MOTS-C Peptide Powder CAS 1627580-64-6 for Research Use

What is MOTS-C?

MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino acid microprotein encoded by mitochondrial DNA. Unlike traditional mitochondrial proteins, MOTS-c acts as a signaling molecule that regulates systemic metabolic homeostasis.

Mechanism of Action

MOTS-c works through two primary pathways：

1. AMPK Pathway Activation (Metabolic Core)

• Inhibits folate cycle and de novo purine synthesis → AICAR accumulation → AMPK activation

• AMPK is the cell’s "energy sensor" that promotes glucose uptake, fatty acid oxidation, and mitochondrial biogenesis

2. CK2 Kinase Binding (Latest Discovery 2024)

• MOTS-c directly binds to and activates the CK2α subunit (KD = 1 nM)

• This mechanism explains its regulatory effects on muscle mass and glucose metabolism

Key Features & Potential Benefits

✅ 1. Glucose & Lipid Metabolism

Enhances insulin sensitivity, improves glycemic control, prevents diet-induced obesity

✅ 2. Muscle Health

Prevents muscle atrophy, promotes myotube formation, enhances muscle glucose uptake

✅ 3. Anti-inflammatory & Neuro protection

Inhibits NF-κB pathway, reduces neurological deficits after traumatic brain injury

✅ 4. Cardiovascular Protection

Improves LVEF and LVFS in diabetic cardiomyopathy, reduces fibrosis and apoptosis

✅ 5. Exercise-mimetic Effects

Exercise induces endogenous MOTS-c; exogenous supplementation mimics some exercise benefits

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