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API Calcium dobesilate

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CAS No.:

20123-80-2

Grade:

Pharmaceutical Grade

Content:

99%

Port:

shanghai

Brand:

Hyper Chem

Packaging:

20kg/Drum 25kg/Drum

Price valid (until):

2026-06-15

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
Seller Information
Inquiry History

Description

Name	Calcium dobesilate
CAS number	20123-80-2
Description	Calcium Dobesilate is a systemic venotonic and capillary protective agent used primarily in the treatment of vascular diseases, particularly chronic venous insufficiency and diabetic microangiopathy.
Related CAS #	/
Synonym	Doxium, Angiofin, Acaldo, Dobesil, Dobesilate
Appearance	Solid powder
Quality Standard	USP, EP, BP, CP
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag
Commercial package	Aluminium Tin, Fiber drum
Origin	China

Calcium Dobesilate More Info

1. Drug Overview

Calcium Dobesilate is a systemic venotonic and capillary protective agent used primarily in the treatment of vascular diseases, particularly chronic venous insufficiency and diabetic microangiopathy.

Key Information:

Generic Name: Calcium Dobesilate

INN (International Nonproprietary Name): Calcium Dobesilate (Rec.INN)

ATC Code: C05BX01

CAS Number: 20123-80-2

Chemical Formula: C₁₂H₁₀CaO₁₀S₂

Molecular Weight: 418.4 g/mol

Chemical Name: 2,5-Dihydroxybenzenesulfonate calcium salt (2:1)

Drug Class: Venoprotective agent / Capillary stabilizer

2. Brand Names

Common commercial names include: Doxium, Angiofin, Acaldo, Dobesil, and Dobesilate.

3. Pharmaceutical Forms & Specifications

Dosage Forms:

Capsules: 500 mg (monohydrate), packaged 30 caps/bottle

Tablets: 250 mg

Bulk Powder: Available in EP/USP/Ph.Eur. grade for compounding

Capsule Description: Yellow body, green cap, size "1", hard gelatin shell containing white powder.

4. Mechanism of Action

Calcium Dobesilate acts through multiple pharmacological pathways:

Anti-platelet Activity: Inhibits platelet activation factor (PAF)

Fibrinolytic Activity: Enhances tissue plasminogen activator (tPA) release

Capillary Protection: Regulates capillary wall functions by reducing permeability and increasing resistance

Blood Rheology Improvement: Reduces serum viscosity and platelet aggregation

Enhanced Red Blood Cell Flexibility: Improves microcirculation flow

Anti-inflammatory & Antioxidant Effects: Reduces oxidative stress and inflammation

5. Therapeutic Indications

Chronic Venous Insufficiency (CVI): Leg heaviness, pain, edema, restless legs syndrome

Diabetic Retinopathy: Microvascular lesions, vision impairment

Hemorrhoidal Syndrome: As adjunctive therapy

Varicose Veins: Vascular fragility and capillary permeability abnormalities

Microangiopathy: Diabetic microvascular complications

Superficial Phlebitis: Adjunctive treatment

6. Dosage and Administration

Indication Recommended Dose Frequency Duration

Chronic Venous Insufficiency 500-1000 mg 2-3 times daily ≥4 weeks

Diabetic Retinopathy 500-1000 mg 2-3 times daily As clinically indicated

Hemorrhoids 500 mg 1-2 times daily As clinically indicated

Administration: Oral administration, preferably with main meals. Dose adjustment based on severity of condition.

7. Pharmacokinetics

Absorption: Well absorbed from the intestine

Peak Plasma Concentration: 8 mcg/ml within 6 hours of oral administration

Distribution: Distributed throughout the body except the brain

Metabolism: Partially metabolized

Excretion: 75% unchanged in urine, 25% in feces (within 24 hours)

8. Contraindications

Hypersensitivity to calcium dobesilate or any excipients

History of agranulocytosis associated with calcium dobesilate

Severe gastrointestinal disorders

Severe hepatic or renal impairment

Pregnancy and breastfeeding (may affect reproduction and is excreted in breast milk)

9. Precautions & Monitoring

Blood Monitoring: Complete blood count and leukogram should be monitored regularly due to risk of agranulocytosis

Discontinuation: Treatment should be discontinued immediately if blood disorders occur

Drug Interactions: Possible interactions with anticoagulants, NSAIDs, and hypoglycemic agents - use under medical supervision

10. Adverse Reactions

Common Side Effects:

Gastrointestinal discomfort

Skin reactions (rash, itching)

Rare but Serious:

Agranulocytosis (requires immediate discontinuation)

Allergic reactions

11. Clinical Benefits

Improves capillary and vein wall integrity

Reduces blood and fluid extravasation and edema

Decreases erythrocyte fragility

Inhibits platelet aggregation

Reduces plasma viscosity

Improves lymph flow and tissue drainage

Accelerates symptom relief in CVI (≥4 weeks treatment)

12. Regulatory Status & Availability

Pharmacopoeia Standards: BP (British Pharmacopoeia), EP (European Pharmacopoeia), IP (Indian Pharmacopoeia)

Manufacturing Certifications: USDMF, EU-GMP certified

Global Availability: Available in multiple countries including Europe, Asia, and Africa

Regulatory Class: Prescription only (Rx Only)

13. Storage

Store at controlled room temperature

Protect from moisture

Keep out of reach of children

Shop API Calcium dobesilate-Detailed Image 1

Basic Info

Product Name:

Calcium dobesilate

Other Name:

Benzenesulfonic acid,2,5-dihydroxy-,calcium salt (2:1);Hydroquinone calcium sulfonate;Calcium bis(2,5-dihydroxybenzenesulfonate);Calcium dobesilate;Calcium p-dihydroxybenzenesulfonate;Doxium;Dobesilate calcium;2,5-Dihydroxybenzenesulfonic acid calcium salt;Calcium 2,5-dihydroxybenzenesulfonate;205E;Dobesilate calcium salt;Hydroquinone calcium sulfate;Dexium;29138-74-7;39038-15-8

CAS No.:

20123-80-2

Molecular Formula:

C6H6O5S.¹/2Ca

InChIKeys:

InChIKey=MVEKZZYTDBDHRF-UHFFFAOYSA-N

Molecular Weight:

418.41

Exact Mass:

417.93413

EC Number:

243-531-5

UNII:

5921X1560Q

DSSTox ID:

DTXSID60173946

ATC Code:

C - Cardiovascular system

HScode:

2924299090

Categories:

Inorganic Salts

Characteristics

PSA:

212

XLogP3:

2.16540

Appearance:

white to beige

Melting Point:

>300 °C (decomp)

Water Solubility:

H2O: soluble15mg/mL, clear

Storage Conditions:

room temp

Toxicity:

LD50 in mice: 700 mg/kg (Esteve-Subirana)

See More Calcium dobesilate Properties 

Hazard Identification

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	none
Prevention	none
Response	none
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Calcium dobesilate Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Certifications:
Certification Report by Bureau Veritas

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
South Korea	Calcium Dobesilate	500	Jul 17, 2025
United States	Calcium dobesilate	10 KG	May 15, 2026

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