Antazoline RC10659
91-75-8
Pharmaceutical Grade
99%
Royalchem
25kg/drum
Yes
2030-01-01
Pharmaceutical intermediates
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Product Details
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Seller Information
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DescriptionECHEMI Editorial ReferenceWhite, odorless crystalline powder with bitter taste. Sparingly soluble in alcohol and water; practically insoluble in benzene and ether.
Solid
Antazoline is a member of the class of imidazolines that is 2-aminomethyl-2-imidazoline in which the exocyclic amino hydrogens are replaced by benzyl and phenyl groups. Antazoline is only found in individuals that have taken the drug. It has a role as a H1-receptor antagonist, a cholinergic antagonist and a xenobiotic. It is a tertiary amino compound, an aromatic amine and a member of imidazolines.|Antazoline is a 1st generation antihistamine with anticholinergic activity. It is used to relieve nasal congestion. It is also formulated as eye drops with naphazoline to relieve allergic conjunctivitis.|Antazoline is an ethylenediamine derivative with histamine H1 antagonistic and sedative properties. Antazoline antagonizes histamine H1 receptor and prevents the typical allergic symptoms caused by histamine activities on capillaries, skin, mucous membranes, and gastrointestinal and bronchial smooth muscles. These histamine activities include vasodilation, bronchoconstriction, increased vascular permeability, pain, itching, and spasmodic contractions of gastrointestinal smooth muscles. Antazoline is used to provide symptomatic relieve of allergic symptoms.|An antagonist of histamine H1 receptors.Basic Info-
Product Name:
Antazoline
Other Name:1H-Imidazole-2-methanamine,4,5-dihydro-N-phenyl-N-(phenylmethyl)-;2-Imidazoline,2-[(N-benzylanilino)methyl]-;4,5-Dihydro-N-phenyl-N-(phenylmethyl)-1H-imidazole-2-methanamine;Allergan A;Antazoline;Antistine;2-[(N-Benzylanilino)methyl]-2-imidazoline;Phenazoline;Analergine
CAS No.:91-75-8
Molecular Formula:C17H19N3
InChIKeys:InChIKey=REYFJDPCWQRWAA-UHFFFAOYSA-N
Molecular Weight:265.35
Exact Mass:265.35
EC Number:202-094-0
UNII:DHA8014SS1
DSSTox ID:DTXSID3022613
NCI Thesaurus Code:C61638
Color/Form:White, crystalline powder
ATC Code:R - Respiratory system
Categories:
Characteristics-
PSA:
27.6
XLogP3:3.38 (est)
Appearance:Solid
Density:1.1±0.1 g/cm3
Melting Point:120-122 °C
Boiling Point:475.5±38.0 °C at 760 mmHg
Flash Point:241.4±26.8 °C
Refractive Index:1.608
Water Solubility:In water, 6.63X10+2 mg/L at 30 deg C
Storage Conditions:Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Vapor Pressure:2.3X10-8 mm Hg at 25 deg C (est)
Toxicity:LD50 oral in mouse: 398mg/kg
Odor:Odorless
Taste:Bitter
Henrys Law Constant:Henry's Law constant = 6.0X10-11 atm-cu m/mol at 25 °C (est)
Dissociation Constants:pKa = 4.90 (non-cyclic tertiary nitrogen); pKa = 10.68 (tertiary imidazoline nitrogen) (est)
Experimental Properties:Hydroxyl radical reaction rate constant = 2.4X10-10 cu cm/molecule-sec at 25 °C (est)
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
Acute toxicity - Category 4, Dermal
Skin irritation, Category 2
Eye irritation, Category 2
Specific target organ toxicity â single exposure, Category 3
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H302 Harmful if swallowed
H312 Harmful in contact with skin
H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P317 Get medical help.
P321 Specific treatment (see ... on this label).
P362+P364 Take off contaminated clothing and wash it before reuse.
P332+P317 If skin irritation occurs: Get medical help.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P319 Get medical help if you feel unwell.
Storage P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Pharmaceutical intermediates
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Location:
Room 336, Building 7, No. 177 Xingqiao North Road, Xingqiao Street, Linping District, Hangzhou
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Payment Terms:
TT against copy of documents,D/P,L/C,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
14 days
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Total Annual Revenue:
Less than $1 million
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Total Employees:
Less than 5
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Year of Establishment:
2025
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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