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Malic acid High-Purity Dicarboxylic Acid for Food, Beverage, Pharmaceutical, and Cosmetic Formulations

Name: Malic acid High-Purity Dicarboxylic Acid for Food, Beverage, Pharmaceutical, and Cosmetic Formulations
Brand: ONERBIO
SKU: pr2606021246
Price: 10.51 USD
Availability: InStock

TDS 15 Inquiries

Unit Price:

$10.51/KG EXW

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CAS No.:

6915-15-7

Grade:

Pharmaceutical Grade

Content:

99%

Port:

Shanghai

Brand:

ONERBIO

Packaging:

25kg/drum

Price valid (until):

2026-12-31

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Wuhan Oner Biotech Co.,Ltd.

Company Type:

Distributor

Location:

China

Qualification:

Main Products:

Nutrition supplement material,Pharmaceutical raw material,Chemical raw material

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Product Description
Seller Information
Inquiry History

Description

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Product Name: Malic Acid
CAS Number: 6915-15-7
Molecular Formula: C₄H₆O₅
Molecular Weight: 134.09 g/mol
Appearance: White to off-white crystalline powder

Malic Acid (CAS 6915-15-7) is a naturally occurring dicarboxylic acid widely found in fruits such as apples and grapes, playing a central role in the Krebs cycle (tricarboxylic acid cycle) as a key metabolic intermediate. It is supplied as a white to off-white crystalline powder with high purity and excellent solubility in water and polar organic solvents. In the food and beverage industry, malic acid is valued for its smooth, tart flavor profile, serving as an acidulant, flavor enhancer, and pH regulator in soft drinks, juices, confectionery, wines, and processed foods, often used in combination with or as an alternative to citric acid. In pharmaceutical applications, it functions as a buffering agent, excipient, and active ingredient in oral care products, effervescent tablets, and dermatological formulations due to its mild exfoliating and moisturizing properties. The compound also finds extensive use in cosmetic and personal care products as a chelating agent, skin conditioning agent, and pH adjuster. Additionally, malic acid is employed in industrial applications including metal cleaning, textile finishing, and polymer synthesis. Its natural origin, versatile functionality, well-established safety profile (GRAS status), and consistent quality make it a preferred choice for manufacturers seeking reliable, multifunctional organic acid solutions across a broad spectrum of consumer and industrial applications.

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ITEMS	STANDARDS		RESULTS
Description	White to almost white powder		White powder
UV absorbance ratio	A250/A260 A280/A260	0.41-0.49 2.03-2.71	0.45 2.14
PH	2.0-4.0		2.68
Loss on drying	≤5.0%		2.64%
Assay (UV)	≥98.0%		99.17%
Transmittance	≥98.5%		99.1%
Heavy metals	≤10ppm		＜10ppm
Purity (HPLC)	≥98.0%		99.6%
Conclusion	It complies to the standard

For regulatory compliance (e.g., USP, EP, JP), raw material Vidarabine must meet several rigorous standards:

Assay (by HPLC): 98.0% – 102.0% on an anhydrous basis.
Related Substances: Limits for specific impurities, notably Ara-Hx (NMT 2.0%), as well as any unspecified individual impurity (NMT 0.1%) and total impurities (NMT 2.0%).
Residual Solvents: Must comply with ICH Q3C guidelines (Class 1 and 2 solvents limited or absent).
Heavy Metals: NMT 20 ppm (typically lower for injectable grades).
Water Content (Karl Fischer): NMT 6.0% (the material is hygroscopic to a degree).
Microbial Limits: Total aerobic microbial count (TAMC) ≤ 1000 CFU/g, absence of S. aureus, P. aeruginosa, and Candida albicans.

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As a high-purity pharmaceutical intermediate, L-Tyrosine Ethyl Ester Hydrochloride is predominantly utilized in the chemical synthesis of bioactive peptides, dopamine analogs, and melanin precursors. Its excellent solubility profile makes it an ideal chiral building block for asymmetric synthesis and a critical substrate in enzymatic reactions. Available in purity grades of ≥98% (HPLC), it meets stringent requirements for R&D and cGMP manufacturing processes. Reliable supply ensures batch-to-batch consistency for long-term project scalability.

Vidarabine is classified as a potential reproductive hazard and an irritant. Safety Data Sheets (SDS) mandate the following:

Hazard Statements (H360): May damage fertility or the unborn child (Category 1B).
Precautionary Measures: Use fume hoods and wear impermeable gloves (e.g., nitrile), lab coats, and safety goggles. Avoid generating airborne dust.
First Aid: In case of skin contact, wash immediately with copious soap and water. If inhaled, move to fresh air.
Storage: Store in tightly sealed, light-resistant containers at 2°C to 8°C (refrigerated) for long-term stability. Avoid freezing.

While superseded by newer nucleoside analogs (Acyclovir, Ganciclovir) for systemic use due to better bioavailability and lower toxicity, Vidarabine retains niche value. Its primary current application is ophthalmic ointment (3%) . Pharmacokinetically, the raw material has poor oral bioavailability (<10%) and is rapidly deaminated in the gastrointestinal tract, necessitating parenteral or topical administration.

Vidarabine API is a well-characterized, stable crystalline nucleoside analog. While its systemic use has declined, it remains a critical raw material for topical antiviral ophthalmic preparations, particularly where resistance to other agents occurs. Manufacturers must strictly control impurities (especially Ara-Hx) and water content to ensure final drug product efficacy.

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Certificates

Basic Info

Product Name:

Malic acid

Other Name:

Butanedioic acid,2-hydroxy-;Malic acid;Butanedioic acid,hydroxy-;2-Hydroxybutanedioic acid;α-Hydroxysuccinic acid;Hydroxysuccinic acid;2-Hydroxyethane-1,2-dicarboxylic acid;Pomalus Acid;Deoxytetraric acid;2-Hydroxysuccinic acid;Musashi-no-Ringosan;Hydroxybutanedioic acid;dl-Malic acid;FDA 2018;(±)-Malic acid;DL-Malic acid;R,S(±)-Malic acid;E 296;NSC 25941;Nanoveson M;Xeros;Monohydroxybutanedioic acid;Purac Powder MA;Purac MA;617-48-1;41308-42-3;623158-98-5;879715-44-3;1334703-48-8

CAS No.:

6915-15-7

Molecular Formula:

C4H6O5

InChIKeys:

InChIKey=BJEPYKJPYRNKOW-UHFFFAOYSA-N

Molecular Weight:

134.09

Exact Mass:

134.09

BRN:

1723539

EC Number:

210-514-9

NSC Number:

25941

DSSTox ID:

DTXSID0027640

Color/Form:

Colorless crystals|White, crystalline triclinic crystals

HScode:

29181980

Categories:

Nutrition Supplements

Characteristics

PSA:

94.8

XLogP3:

-1.26

Appearance:

DryPowder; OtherSolid, Liquid

Density:

1.601 g/ cu cm at 20 deg C

Melting Point:

131 °C

Boiling Point:

167.16°C (rough estimate)

Flash Point:

203 °C

Water Solubility:

H2O: 558 g/L (20 ºC);methanol: 0.1 g/mL, clear, colorless

Storage Conditions:

2-8°C

Vapor Pressure:

<0.1 mm Hg ( 20 °C)

Vapor Density:

4.6 (vs air)

Toxicity:

LD50 orally in Rabbit: > 3200 mg/kg

Odor:

Characteristic

Taste:

Smoothly tart

PH:

pH of a 0.001% aqueous solution is 3.80, that of 0.1% solution is 2.80, and that of a 1.0% solution is 2.34

Henrys Law Constant:

Henry's Law constant = 8.4X10-13 atm-cu m/mol at 25 °C (est)

Dissociation Constants:

Ionization constants: K1 = 4X10-4; K2 = 9X10-6|pKa1 = 3.51; pKa2 = 5.03 at 20 °C /OECD Guideline 112 (Dissociation Constants in Water)/

Collision Cross Section:

115.9 Å² [M-H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]

Experimental Properties:

Nearly odorless (sometimes a faint, acrid odor) /L-Malic Acid/|Exhibits isomeric forms (dl, l, and d)|Density: 1.601 (d or l form); MP: 128 °C (d or l form); BP: 140 °C with decomposition (d or l form)|Crystals from acetone, or acetone + chloroform; mp 100 °C; Decomposes at about 140 °C; specific optical rotation: -2.3 deg (conc = 8.5 g 1100 ml water); Solubilities at 20 °C: 60.66 g/100 g acetone, 74.35 g/100 g dioxane, 36.35 g/100 g water, practically insoluble in benzene, 197.22 g/100 g methanol, 2.70 g/100 g diethyl ether, 86.60 g/100 ethanol; L-(-)-Form/|BUFFERING INDEX: 3.26|SPECIFIC OPTICAL ROTATION: -5.7 DEG /L-FORM/, +5.2 DEG /D-FORM/ @ 18 °C (IN ACETONE)

Heat of Combustion:

-1.340 MJ/mol at 20 °C

See More Malic acid Properties 

Hazard Identification

Classification of the substance or mixture

Eye irritation, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H319 Causes serious eye irritation
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response	P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non Combustible Solids.

See More Malic acid Safety Data Sheet 

Seller Information

Business Type:
Distributor

Main Products:
Nutrition supplement material,Pharmaceutical raw material,Chemical raw material

Location:
Changqing 5th Road, Jianghan District

Payment Terms:
TT against copy of documents

Average lead Time:
5

Total Annual Revenue:
$1 million-$2.5 million

Total Employees:
5-10

Year of Establishment:
2020

Wuhan Oner Biotech Co.,Ltd. located in the popular city of Wuhan, specilize in producing and developing pharmaceutical & its intermediates, Cosmetics Raw Material and Intermediate, food additive, Plant extracts,and in distributing the products of our own company. We serves our clients by supplying high-quality.These products are manufactured in ISO 9001 certified plants and have continuously been passing quality inspection by CIQ (China Entry & Exit Inspection and Quarantine Bureau),100% pass rate. Our company has professional staff who deal with chemical R&D and scientific management, and holds several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and Spectrophotometer. We have professional sales team, focus on quality and service, and we have achieved excellent performance over the years. Our company is committed to the development of international market , the products are mainly exported to many countries and regions, such as Europe, America, South-east Asia, the Middle East and Africa etc. With constant efforts and good service, We sincerely hope to establish long-term cooperation and common development with our customers.

Inquiry History

15 Inquiries

Country	Product	Purchase Quantity	Date Posted
Nigeria	Malic Acid	68 MT	Feb 2, 2026
United States	Malic Acid	4000 KG	Jun 17, 2025
Algeria	Malic Acid	25 KG	Feb 28, 2025
Jordan	Malic acid	1000 KG	Dec 23, 2024
Nigeria	Malic Acid	25000 MT	Jul 19, 2024
Egypt	MALIC ACID	1000 KG	Apr 16, 2024
United Kingdom	Malic Acid	1000 KG	Mar 17, 2026
Russia	Malic acid	20 TON	Dec 11, 2023
Singapore	malic acid	1 KG	Oct 12, 2023
Peru	Malic Acid	1 20' Fcl	Nov 27, 2025
Bangladesh	Malic Acid (Powder)	25.00 KG	Sep 9, 2025
United Kingdom	Malic Acid	1 MT	Jan 13, 2025
India	Malic Acid Powder	25.00 KG	May 30, 2024
Russia	DL–malic acid	1 20' Fcl	Nov 30, 2023
Saudi Arabia	Malic Acid	2.00 MT	Jul 14, 2023

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