IGF 1LR3

Product Description – The Science of IGF‑1 LR3 in Dermal Research
IGF‑1 LR3 (Insulin‑like Growth Factor‑1 Long Arginine 3, also known as Long‑R³‑IGF‑I) is a recombinant synthetic analogue of human IGF‑1, engineered to possess significantly enhanced biological activity and metabolic stability. Native IGF‑1 is a naturally occurring peptide hormone produced by dermal fibroblasts, where it acts in an autocrine and paracrine manner to stimulate cell proliferation, support collagen synthesis, and maintain the structural integrity of the extracellular matrix (ECM) [8†L25-L28][1†L16-L21].
IGF‑1 LR3 is an 83‑amino‑acid single‑chain polypeptide with a molecular mass of approximately 9 kDa. It was developed in the late 1980s and early 1990s through site‑directed mutagenesis to overcome the limitations of native IGF‑1, which binds with high affinity to a family of six IGF‑binding proteins (IGFBPs) that sequester the peptide and drastically reduce its bioavailability [12†L10-L15][0†L6-L9]. Two key modifications define the LR3 variant [10†L26-L35][0†L14-L18]:
• R3 (Arginine‑3) Substitution – The third amino acid of native IGF‑1 (glutamic acid, Glu) is replaced with arginine (Arg). This change reduces the peptide's affinity for IGFBPs by approximately 1000‑fold, resulting in a significantly higher free‑peptide concentration in the cellular environment and an approximately two‑ to three‑fold increase in biological potency [7†L25-L30].
• N‑terminal 13‑Amino‑Acid Extension – An additional 13‑amino‑acid leader sequence (MFPAMPLLSLFVN) is appended to the N‑terminus, extending the total length from 70 to 83 amino acids. This extension further enhances the molecule's stability and reduces its susceptibility to proteolytic degradation.
Together, these modifications extend the half‑life of IGF‑1 LR3 in biological systems to approximately 20–30 hours (compared to 12–15 hours for native IGF‑1) and improve its biological potency by a factor of approximately three, while preserving full agonist activity at the IGF‑1 receptor (IGF1R) [10†L32-L38][5†L5-L7].
Relevance to Dermal Biology and ECM Support
The skin is a complex neuro‑endocrine organ that expresses functional receptors for numerous growth factors. In particular, IGF‑1 is produced by dermal fibroblasts, where it acts through the IGF‑1 receptor to:
• Stimulate fibroblast proliferation – IGF‑1 is mitogenic for fibroblasts, supporting the maintenance of a healthy, functional dermal cell population [8†L20-L27].
• Enhance collagen and elastin synthesis – In vitro studies have shown that IGF‑1 increases collagen and elastin production by skin fibroblasts, while also promoting keratinocyte proliferation, thereby contributing to dermal matrix integrity and epidermal renewal [1†L35-L40].
• Support angiogenesis and tissue repair – IGF‑I induces endothelial cell migration and is involved in the regulation of angiogenesis, a critical process for wound healing and tissue regeneration [8†L23-L24].
While much of the published research describes the effects of the endogenous hormone, the LR3 variant — with its extended half‑life and reduced IGFBP sequestration — offers a more sustained and potent activation of these same pathways. In topical formulation research, this makes IGF‑1 LR3 a compelling candidate for products intended to support dermal resilience, improve skin texture, and assist in repair processes.
Documented Research in Wound Healing and Repair
IGF‑1 LR3 has been investigated in controlled laboratory models for its ability to accelerate tissue repair. Documented properties include [7†L16-L18][3†L37-L40]:
• Fibroblast proliferation – Enhances the number of fibroblasts at the site of interest, supporting the formation of granulation tissue.
• Collagen synthesis – Promotes the production of new collagen fibres, improving the structural foundation of healing tissue.
• Keratinocyte migration – Facilitates re‑epithelialisation by promoting the colonisation of keratinocytes over the wound bed.
• Angiogenesis – Stimulates the formation of new blood vessels, ensuring adequate oxygen and nutrient delivery to regenerating tissues.
These observations, combined with the peptide's neurotrophic potential (promoting axonal regeneration and neuronal survival), support the exploration of IGF‑1 LR3 in advanced topical formulations targeting skin ageing, recovery, and environmental defence [7†L14-L15].

1. Ultra-High Purity

Each batch is synthesized and purified to >99% purity (HPLC), ensuring reliable and reproducible results in sensitive experiments.
2.Accurate Dosing & Consistency
Our peptides are precisely weighed and vacuum-sealed under sterile conditions. Batch-to-batch consistency is rigorously maintained.
3.Endotoxin-Free & Sterile Processing
Manufactured in a cleanroom environment, our peptides are free from endotoxins, microbial contamination, and other impurities that could interfere with cell-based or in vivo studies.

Sales manager:  Eira

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1. Advanced Manufacturing Capabilities

Cutting-Edge Facilities: High-precision equipment ensuring purity and bioactivity.

Scalable Production: From milligram-scale research peptides to multi-kilogram industrial batches.

2. Innovation & Customer Commitment

Reliable Supply Chain: Competitive pricing & timely global delivery.

Global Reach: Trusted by researchers, pharmaceutical firms & industrial clients worldwide.

Q1: May I get one sample before placing order?
Re: Yes, Sample are available. For normal products, samples are for free and you just need to bear the freight; For those high value products, you just need to freight and certain product cost. When we both cooperate for some times or when you are our VIP customer, free sample will be offered when you need.
Q2: Which payment is available for your company?
Re: T/T, PayPal,bank transfer etc. You can choose the one which is convenient for you.
Q3: How and when can I get my goods after payment?
Re: For small quantity products, they will be delivered to you by international courier(DHL, FedEx, TNT etc.) or by air. Usually it will cost 5-7days that you can get the goods after delivery.For large quantity products, shipping by see is worthwhile.It will cost 15 to 30 days to come to your destination port, which depends on where the port is.
Q4: Is there any possible to use my appointed label or package?
Re: Yes. If needed, we'd lik.

1. Expertise in Peptide Synthesis
Extensive Experience: 7 Years of expertise in synthetic peptide development.
Skilled Team: Experts in solid-phase and liquid-phase synthesis.
2. Advanced Manufacturing Capabilities
Cutting-Edge Facilities: High-precision equipment ensuring purity and bioactivity.
Scalable Production: From milligram-scale research peptides to multi-kilogram industrial batches.
3. Innovation & Customer Commitment
Reliable Supply Chain: Competitive pricing & timely global delivery.
Global Reach: Trusted by researchers, pharmaceutical firms & industrial clients worldwide.
4. Ultra-High Purity
Each batch is synthesized and purified to >99% purity (HPLC), ensuring reliable and reproducible results in sensitive experiments.
5.Accurate Dosing & Consistency
Our peptides are precisely weighed and vacuum-sealed under sterile conditions. Batch-to-batch consistency is rigorously maintained.
6.Endotoxin-Free & Sterile Processing
Manufactured in a cleanroom environment, our peptides are free from endotoxins, microbial contamination, and other impurities that could interfere with cell-based or in vivo studies.

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