KissPeptin-10 High Quality 99% Purity Powder good price 374675-21-5

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① Reproductive Regulation: Kisspeptin-10 plays a crucial role in reproductive biology and is a key regulator of the hypothalamic-pituitary-gonadal axis. It primarily regulates gonadal function and the reproductive cycle by binding to the kissin receptor GPR54 (also known as KISS1), influencing the secretion of gonadotropin-releasing hormone (GnRH). In rodent models, kisspeptin-10 plays a crucial role in the onset of puberty and the maintenance of reproductive function.

② Vasoconstriction and Angiogenesis: Kisspeptin-10 not only plays a role in the reproductive system but also has potential effects on the cardiovascular system. Studies have shown that kisspeptin-10 can increase cardiac contractility and induce fibrosis and changes in mitochondrial structure in rat heart tissue. These changes suggest that kisspeptin-10 may play a key role in the pathogenesis of heart disease.

③ Antioxidant Activity: Studies have shown that kisspeptin-10 also has potential antioxidant activity, potentially reducing the reproductive toxicity induced by certain drugs, such as methotrexate, this makes kisspeptin-10 a potential therapeutic peptide that can be used to improve sexual desire, muscle growth, and other aspects.

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Triple Agonist Design :

GLP-1 receptor: Retatrutide delays gastric emptying, suppress appetite, and promote secretion.

GIP receptor: Retatrutide enhances sensitivity and regulate central satiety signals.

Glucagon receptor (GCGR): Retatrutide activates liver energy metabolism, promote lipolysis and glycogenolysis, and increase basal metabolic rate.

The triple synergistic effect increases energy consumption while reducing energy intake, significantly improving weight loss effects.

Mechanism of Action and Molecular Structure of Retatrutide:

1)Triple Agonist Design
- GLP-1 receptor: Retatrutide delays gastric emptying, suppress appetite, and promote secretion.
- GIP receptor: Retatrutide enhances insulin sensitivity and regulate central satiety signals.
- Glucagon receptor (GCGR): Retatrutide activates liver energy metabolism, promote lipolysis and glycogenolysis, and increase basal metabolic rate.
The triple synergistic effect increases energy consumption while reducing energy intake, significantly improving weight loss effects.

2) Structural Optimization
- Based on the GIP skeleton modification, non-natural amino acids (such as α-methylleucine at position 13) are introduced to enhance receptor affinity.
- The half-life is extended to 7 days through fatty acid side chain modification