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Dalbergioidin

Name: Dalbergioidin
Brand: Cuicheng Bio
SKU: pr2606081142
Price: 1600 USD
Availability: InStock

Unit Price:

$1600-1800/G FOB

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CAS No.:

30368-42-4

Grade:

Industrial Grade

Content:

98%

Port:

guangzhou

Brand:

Cuicheng Bio

Packaging:

5mg

Price valid (until):

2026-07-08

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Cuicheng Biomedical Technology

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

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Product Description
Seller Information

Description

Dalbergioidin is a naturally occurring isoflavonoid (specifically an isoflavanone) found in several medicinal and leguminous plants, such as Uraria crinita, Lespedeza cyrtobotrya, and rosewood species like Dalbergia odorifera. Its primary functions span kidney tissue protection, melanin biosynthesis inhibition, bone defense, and plant chemical immunity.

1. Antifibrotic and Kidney Protection

Suppression of Renal Fibrosis: Dalbergioidin serves as a potent protective molecule against drug-induced kidney damage (nephrotoxicity). Research shows that it dramatically ameliorates renal fibrosis caused by chemotherapy agents like doxorubicin.
TGF-β Signaling Blockade: It exerts its antifibrotic action by directly suppressing the Transforming Growth Factor-beta (TGF-β) signaling pathway. It reduces the phosphorylation of Smad3 (a driver of scar tissue formation) and upregulates the protective, inhibitory protein Smad7. This shifts kidney markers back toward a healthy, functioning state.

2. Melanin Biosynthesis and Tyrosinase Inhibition

Noncompetitive Tyrosinase Inhibitor: In dermatology and cosmetic chemistry, dalbergioidin functions as an active skin-brightening agent. It acts as a noncompetitive inhibitor of tyrosinase, the core rate-limiting enzyme responsible for producing melanin.
- Hyperpigmentation Prevention: By blocking melanin biosynthesis pipelines, it helps downregulate hyperpigmentation, age spots, and uneven skin tones, making its parent extracts (like Lespedeza cyrtobotrya) valuable in cosmetics.
3. Osteoblast Protection and Bone Health
- Mitigating Oxidative Bone Damage: In skeletal health, dalbergioidin operates as a cellular shield for bone-forming cells. It protects MC3T3-E1 osteoblastic cells from oxidative stress and hydrogen peroxide-induced cell death.
- Activation of Osteogenic Pathways: It rescues damaged bone cells by selectively turning on the PI3K/AKT/SMAD1 signaling network, which promotes osteoblast survival and helps maintain structural bone remodeling kinetics.
4. Botanical Defense and Antioxidant Activity
- Natural Phytoalexin: Within the Fabaceae (legume) plant family, dalbergioidin acts as a defensive secondary metabolite. It provides localized chemical immunity against environmental stress, deterring herbivorous insects and neutralizing predatory fungal or bacterial pathogens.
- - Free Radical Scavenger: Rich in phenolic hydroxyl groups, its chemical framework operates as a functional antioxidant. It quenches reactive oxygen species (ROS), protecting surrounding cellular membranes from lipid peroxidation and oxidative degradation.
  5. Chemotaxonomic Reference Tool
  - Quality Control Marker: High-purity dalbergioidin is used in analytical laboratories as a certified phytochemical standard. Analysts utilize it in HPLC and LC-MS to verify the authenticity of high-value traditional medicines (like the heartwood of Dalbergia odorifera, known as Jiangxiang), ensuring products are free from counterfeits.

Basic Info

Product Name:

3-(2,4-Dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-4H-1-benzopyran-4-one

Other Name:

4H-1-Benzopyran-4-one,3-(2,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-;Isoflavanone,2′,4′,5,7-tetrahydroxy-;3-(2,4-Dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-4H-1-benzopyran-4-one;Dalbergioidin

CAS No.:

30368-42-4

Molecular Formula:

C15H12O6

InChIKeys:

InChIKey=WNHXBLZBOWXNQO-UHFFFAOYSA-N

Molecular Weight:

288.25218

Exact Mass:

288.25

Categories:

Flavonoids

Characteristics

PSA:

107

XLogP3:

2.2

Density:

1.586±0.06 g/cm3(Predicted)

Water Solubility:

824.2 mg/L @ 25 °C (est)

See More 3-(2,4-Dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-4H-1-benzopyran-4-one Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More 3-(2,4-Dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-4H-1-benzopyran-4-one Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

Location:
Chuangzhi valley,Chuangzhi Industrial Park ,Hanzhong Economic and Technological Dvelopment Zone,Hanzhong City, Shaanxi Province

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
51-100

Year of Establishment:
2019
Country Product Purchase Quantity Date Posted

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Dalbergioidin

Product Description

Seller Information

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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