MS40 40mg

Pls inputGuangzhou Boyuan Outdoor Products Co., Ltd., originally established to serve the rigorous demands of outdoor chemical applications where resilience against temperature fluctuation, humidity, and mechanical stress is paramount, has since pivoted its core competency toward the advanced synthesis of high-purity research peptides and standardized botanical actives, operating out of Guangzhou's premier biotech hub and leveraging the city's world-class logistics infrastructure to ship temperature-sensitive products to over 40 countries including the United States, Germany, Japan, and Brazil. Our biotechnology division specializes in custom and catalog peptide synthesis, producing both linear and cyclic peptides with lengths ranging from 5 to 50 amino acids, including melanocortin analogs and custom sequences for research institutions, utilizing Solid-Phase Peptide Synthesis (SPPS) with both Fmoc and t-Boc chemistries to routinely achieve crude purity >85% and purified purity ≥99% via preparative HPLC. Every batch of peptide or extract leaving our facility undergoes a rigorous four-step validation: HPLC to quantify purity and detect truncated sequences, Mass Spectrometry (MS) to confirm molecular weight within ±0.1 Da, endotoxin and bioburden testing for cell-culture grade materials, and stability studies including accelerated aging tests at 40°C/75% RH simulating 24 months of shelf life. Our heritage in outdoor products taught us how to protect chemicals from environmental stress, and we apply the same principles to peptide shipping by using insulated containers with pharmaceutical-grade desiccants for lyophilized peptides, offering temperature-controlled options (2-8°C blue ice packs or -20°C dry ice) for long-haul international orders, and providing real-time tracking integrated with major carriers like DHL, FedEx, and UPS, all while operating in alignment with ISO 9001:2015, GMP guidelines for dietary supplement ingredients, and REACH & RoHS compliance for European exports. Within our diverse product portfolio, one of our featured offerings is MS-10, a standardized, synergistic botanical complex developed for nutraceutical and functional food applications that combines two traditional medicinal plants: Korean Thistle (Cirsium japonicum var. ussuriense), historically used in East Asian herbalism for its hemostatic and anti-inflammatory properties, and Common Thyme (Thymus vulgaris), a Mediterranean herb recognized for its antiseptic, antioxidant, and carminative effects. The "MS" designation refers to "Metabolic Support" and "10" indicates the 10:1 extract ratio, meaning 10 kilograms of raw plant material yield 1 kilogram of standardized extract. MS-10 presents as a brownish-yellow to light brown fine powder with a characteristic herbal, slightly minty odor, 100% passing through an 80 mesh sieve, fully soluble in water, with loss on drying ≤5.0%, heavy metals total ≤10 ppm (with Pb, As, Hg, Cd individually ≤1 ppm), and microbiology meeting stringent standards (total plate count <1,000 cfu/g; yeast and mold <100 cfu/g; E. coli and Salmonella absent). The product model number is MS10-HB, and because it is a complex botanical blend, it does not carry a single CAS number. MS-10 contains a rich matrix of bioactive secondary metabolites, including luteolin-7-O-glucoside (0.5–1.2% from thistle, a flavone with documented antioxidant and anti-inflammatory activity), pectolinarin (a flavone glycoside unique to Cirsium species studied for osteoprotective effects), thymol (0.3–0.8% from thyme, a monoterpenoid with antimicrobial and vasodilatory properties), and rosmarinic acid (a caffeic acid dimer with potent antioxidant capacity, ORAC value ~1,500 µmol TE/g). Based on peer-reviewed research, MS-10 targets three primary physiological systems: skeletal and bone metabolism, where Korean Thistle flavonoids inhibit osteoclast differentiation via downregulation of RANKL signaling pathways and promote osteoblast activity by increasing alkaline phosphatase expression; hormonal balance and menopausal support, where the phytoestrogenic potential of MS-10 exhibits selective binding to ERβ over ERα (suggesting a favorable safety profile for uterine and breast tissue) while thyme-derived rosmarinic acid reduces hot flash frequency in perimenopausal models and modulates serotonin turnover in the hypothalamus; and antioxidant and anti-inflammatory defense, where the combination of luteolin and rosmarinic acid scavenges superoxide anions and hydroxyl radicals, chelates transition metal ions to prevent Fenton chemistry and lipid peroxidation, and upregulates endogenous antioxidant enzymes via Nrf2 pathway activation. Valid applications for MS-10 include nutraceutical formulations (menopause support formulas, bone health supplements with calcium and vitamin D3, joint health matrices, antioxidant blends), functional foods and beverages (herbal tea blends, protein shakes, meal replacement bars, effervescent tablets), and cosmeceutical topical applications (anti-aging creams, post-sun exposure lotions, scalp serums). Stability studies demonstrate that MS-10 remains stable for 36 months at 25°C/60% RH with no significant change in marker compound levels, shows <5% degradation after 6 months at 40°C/75% RH, and retains >90% potency after light exposure of 1.2 million lux-hours. Storage recommendations include keeping the product in its original tightly sealed container away from direct sunlight at 15–25°C (59–77°F), avoiding refrigeration unless ambient exceeds 30°C for extended periods, and using within 6 months of opening with immediate resealing to prevent moisture absorption. For in vitro research, a 10 mg/mL stock solution can be prepared fresh in DMSO and further diluted in cell culture medium (final DMSO concentration <0.1%), or for aqueous solutions, warm purified water to 37°C and stir slowly for full dissolution within 10 minutes at 1–5% w/v, then filter sterilize using a 0.22 µm PES membrane (avoid cellulose acetate filters which may bind polyphenols). Toxicological data, including a 90-day subchronic oral toxicity study in Sprague-Dawley rats, established a NOAEL of 2,000 mg/kg body weight per day, with negative genotoxicity results in the Ames test and in vitro micronucleus assay, no histopathological changes in liver, kidney, spleen, or reproductive organs at doses up to 1,000 mg/kg/day, and low risk of herb-drug interactions (CYP450 inhibition IC50 >100 µM for CYP3A4, 2D6, and 2C9). Guangzhou Boyuan distinguishes its MS-10 offering through three proprietary quality steps: HPLC fingerprinting requiring ≥90% similarity index to reference standards; third-party accredited pesticide and heavy metal screening meeting California Prop 65 and EU 2020/1245 standards; and a terminal steam sterilization step (121°C for 15 minutes) prior to spray drying to ensure total plate count consistently below 500 cfu/g. Packaging options range from 100 g foil-lined kraft bags for lab-scale R&D, 500 g HDPE bottles for pilot batches, 1 kg double-layer foil bags for small production runs, 5 kg triple-layer liner boxes for commercial manufacturing, to 25 kg fiber drums for bulk supply. For peptides, we offer vials from 1 mg to 100 mg for research use and bulk quantities from 1 g to 1 kg for pre-clinical supply agreements, with custom synthesis services available for non-catalog sequences including N-terminal acetylation, C-terminal amidation, biotin or FITC labeling, and cyclization via disulfide or lactam bridges, with lead times of 2–4 weeks. Guangzhou Boyuan Outdoor Products Co., Ltd. supplies all products strictly for research, dietary supplement manufacturing, and cosmetic formulation use only—not for direct human consumption, not intended to diagnose, treat, cure, or prevent any disease, and the buyer assumes all responsibility for compliance with local regulations regarding final product formulation and labeling, with a detailed Certificate of Analysis including HPLC chromatograms, heavy metals and pesticide residue quantification, microbial test results, and loss on drying verification accompanying every shipment....