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1-Bromo-3-chloropropane109-70-6

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CAS No.:

109-70-6

Grade:

Industrial Grade

Content:

99.5%

Port:

上海

Brand:

OORENT

Packaging:

Vial/Bottle/Bag/Carton

Price valid (until):

2026-07-17

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Qingdao Orient Chemical Co.,LTD

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Product Description
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Description

Product Detail

1-Bromo-3-chloropropane Basic information

Product Name:	1-Bromo-3-chloropropane
Synonyms:	1-bromo-3-chloro-propan;3-Bromo-1-chloropropane;3-Chloro-1-bromopropane;omega-Chlorobromopropane;Propane,1-bromo-3-chloro-;Trimethylene bromide chloride;trimethylenebromidechloride;TRIMETHYLENE CHLOROBROMIDE
CAS:	109-70-6
MF:	C3H6BrCl
MW:	157.44
EINECS:	203-697-1
Product Categories:	API Intermediate;Pharmaceutical intermediates;Organics;BROMO CHLORO;omega-Functional Alkanols, Carboxylic Acids, Amines & Halides;omega-Haloalkyl Chlorides;109-70-6;K00001
Mol File:	109-70-6.mol

1-Bromo-3-chloropropane Chemical Properties

Melting point	-59 °C
Boiling point	144-145 °C (lit.)
density	1.592 g/mL at 25 °C (lit.)
vapor pressure	7.5 hPa (20 °C)
refractive index	n20/D 1.486(lit.)
Fp	81 °C
storage temp.	room temp
solubility	2.24g/l insoluble
form	liquid
color	Clear liquid
explosive limit	3.2-8.6%(V)
Water Solubility	insoluble
BRN	605278
Henry's Law Constant	3.9×10^-2 mol/(m³Pa) at 25℃, HSDB (2015)
Stability:	Volatile
InChI	1S/C3H6BrCl/c4-2-1-3-5/h1-3H2
InChIKey	MFESCIUQSIBMSM-UHFFFAOYSA-N
SMILES	ClCCCBr
CAS DataBase Reference	109-70-6(CAS DataBase Reference)
IARC	2B (Vol. 125)
NIST Chemistry Reference	Propane, 1-bromo-3-chloro-(109-70-6)
EPA Substance Registry System	Propane, 1-bromo-3-chloro- (109-70-6)

Safety Information

Hazard Codes	Xn
Risk Statements	10-22-36/37/38-20/21/22-20/22-68-52/53-37
Safety Statements	16-45-36/37/39-26
RIDADR	UN 2688
WGK Germany	3
RTECS	TX4113000
TSCA	TSCA listed
HazardClass	6.1
PackingGroup	III
HS Code	29034980
Storage Class	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
Hazard Classifications	Acute Tox. 3 Inhalation Acute Tox. 4 Oral Aquatic Chronic 3 Muta. 2 STOT SE 3
Hazardous Substances Data	109-70-6(Hazardous Substances Data)
Toxicity	LD50 orally in Rabbit: 1100 - 1200 mg/kg LD50 dermal Rat > 2000 mg/kg

MSDS Information

Provider	Language
1-Chloro-3-bromopropane	English
ACROS	English
SigmaAldrich	English
ALFA	English

1-Bromo-3-chloropropane Usage And Synthesis

Description	1-Bromo-3-chloropropane is a halogenated alkane compound containing one bromine atom and one chlorine atom in its structure. Due to the high electronegativity of halogens, the molecule of 1-Bromo-3-chloropropane is highly electrophilic and is easily attacked by electrophilic reagents such as nucleophilic reagents, Lewis acid, etc., which undergoes nucleophilic substitution reactions. The compound is relatively stable at room temperature, but is susceptible to elimination reactions at high temperatures or in the presence of strong acids or bases. In addition, prolonged exposure to air should be avoided because 1-Bromo-3-chloropropane molecules contain halogen atoms that are susceptible to reaction by oxygen and moisture in the air to produce products such as alcohols and aldehydes.
Chemical Properties	It is a clear and colorless liquid that is soluble in ethanol, ether, and chloroform but insoluble in water.
Uses	1-Bromo-3-chloropropane is used in the preparation active pharmaceutical ingredient intermediate such as gemfibrozil and reproterol. It is also involved in the preparation of cardiovascular diseases and analgesic drugs materials. It is utilized as a phase separation reagent for the isolation of ribonucleic acid (RNA) in high quality. It is considered as a replacement of chloroform in nucleic acid separations.
Preparation	The most common method for producing 1-Bromo-3-chloropropane is through the free-radical addition of anhydrous hydrogen bromide to allyl chloride. Alternatively, it can be prepared by reacting ethylene with methylene chlorobromide.
Definition	ChEBI: 1-Bromo-3-chloropropane (I-BCP or 109-70-6) is an organochlorine compound that can be used as a safer and equally effective alternative to chloroform. It serves as a phase-separation agent for the one-step method of RNA isolation from biological samples like animal and plant tissue. I-BCP can replace CHCl3 in RNA phase separations.
General Description	1-bromo-3-chloropropane appears as a colorless liquid. Insoluble in water and denser than water. May be toxic by inhalation, ingestion or skin absorption. Used to make pharmaceuticals and other chemicals.
Air & Water Reactions	Insoluble in water.
Reactivity Profile	Halogenated aliphatic compounds, such as 1-Bromo-3-chloropropane, are moderately or very reactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Materials in this group are incompatible with strong oxidizing and reducing agents. Also, they are incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.
Health Hazard	Inhalation of vapors or dust is extremely irritating. May cause burning of eyes and flow of tears. May cause coughing, difficult breathing and nausea. Brief exposure effects last only a few minutes. Exposure in an enclosed area may be very harmful. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may cause pollution.
Fire Hazard	Some of these materials may burn, but none ignite readily. Containers may explode when heated.
Safety Profile	Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of Cland Br-. See also CHLORINATED HYDROCARBONS, ALIPHATIC; and BROMIDES.
Purification Methods	Wash it with conc H2SO4, water, 10% Na2CO3 solution, water again and then dry with CaCl2 and fractionally distil it just before use [Akagi et al. J Am Chem Soc 78 4034 1956]. [Beilstein 1 H 109, 1 IV 212.]
Toxics Screening Level	The initial threshold screening level (ITSL) for 1-Bromo-3-chloropropane is 0.1 μg/m3 based on an annual averaging time.

1-Bromo-3-chloropropane Preparation Products And Raw materials

Raw materials

Hydrogen bromide-->Benzoyl peroxide-->Allyl chloride

Preparation Products

Azetidine-->1-(3-(pyrrolidin-1-yl)propyl)hydrazine-->Azetidine hydrochloride-->(Bromomethyl)cyclobutane-->1-(3-Hydrazinylpropyl)pyrrolidin-2-one-->(3-MORPHOLIN-4-YL-PROPYL)-HYDRAZINE-->SEMOTIADIL-->Tirofiban-->1,1-Cyclobutanedicarboxylic acid-->5-chloro-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile-->Oxatomide-->4-Chlorobutyronitrile-->1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride-->Difenidol hydrochloride-->ACETOPHENAZINE MALEATE (200 MG)-->Cyclobutanemethanol-->1-Bromo-5-hexanone-->LOMIFYLLINE-->Pentoxifylline-->Nefazodone-->PERPHENAZINE-->Chlorpromazine hydrochloride-->Julolidine-->3-ETHOXYCARBONYL-5,6-DIHYDRO-2-METHYL-4H-PYRAN

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Basic Info

Product Name:

1-Bromo-3-chloropropane

Other Name:

Propane,1-bromo-3-chloro-;1-Bromo-3-chloropropane;Trimethylene bromide chloride;Trimethylene chlorobromide;1-Chloro-3-bromopropane;3-Chloro-1-bromopropane;3-Bromopropyl chloride;3-Bromo-1-chloropropane;3-Chloropropyl bromide;ω-Chlorobromopropane;NSC 9183;3-Chloropropan-1-yl bromide

CAS No.:

109-70-6

Molecular Formula:

C3H6BrCl

InChIKeys:

InChIKey=MFESCIUQSIBMSM-UHFFFAOYSA-N

Molecular Weight:

157.44

Exact Mass:

157.44

BRN:

605278

EC Number:

203-697-1

UNII:

KA4WR2LS00

ICSC Number:

1665

NSC Number:

9183

UN Number:

2688

DSSTox ID:

DTXSID1051565

Color/Form:

COLORLESS LIQUID

HScode:

29034980

Categories:

Hydrocarbons and Derivatives

Characteristics

PSA:

XLogP3:

2.18

Appearance:

1-bromo-3-chloropropane appears as a colorless liquid. Insoluble in water and denser than water. May be toxic by inhalation, ingestion or skin absorption. Used to make pharmaceuticals and other chemicals.

Density:

1.5969 g/cm³ @ Temp: 20 °C

Melting Point:

-58.90 °C

Boiling Point:

143.3 °C @ Press: 760 Torr

Flash Point:

81 °C

Refractive Index:

n 20/D 1.486(lit.)

Water Solubility:

H2O: insoluble

Storage Conditions:

room temp

Vapor Pressure:

Vapour pressure, kPa at 25°C: 0.85

Vapor Density:

Relative vapour density (air = 1): 5.4

Toxicity:

Oral-Rat LD50: 930 mg/kg; Oral-Mouse LD50:1290 mg/kg

Flammability characteristics:

Open flame is flammable; reacts with oxidant; decomposes with high heat and emits toxic chlorine and bromide gas in case of acid

Explosive limit:

3.2-8.6%(V)

Experimental Properties:

LB/GAL: 13.27 @ 25 °C

Air and Water Reactions:

Insoluble in water.

Reactive Group:

Halogenated Organic Compounds

Reactivity Profile:

Halogenated aliphatic compounds, such as 1-BROMO-3-CHLOROPROPANE, are moderately or very reactive. Halogenated organics generally become less reactive as more of their hydrogen atoms are replaced with halogen atoms. Materials in this group are incompatible with strong oxidizing and reducing agents. Also, they are incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.

See More 1-Bromo-3-chloropropane Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

Acute toxicity - Category 3, Inhalation

Specific target organ toxicity â single exposure, Category 3

Germ cell mutagenicity, Category 2

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H302 Harmful if swallowed H331 Toxic if inhaled H335 May cause respiratory irritation H341 Suspected of causing genetic defects H412 Harmful to aquatic life with long lasting effects
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P273 Avoid release to the environment.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P316 Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P319 Get medical help if you feel unwell. P318 IF exposed or concerned, get medical advice.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

NO open flames, NO sparks and NO smoking. Above 57Â°C use a closed system, ventilation and explosion-proof electrical equipment. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Separated from food and feedstuffs. Well closed. Store in an area without drain or sewer access.

See More 1-Bromo-3-chloropropane Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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Inquiry History

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Country	Product	Purchase Quantity	Date Posted
India	1-Bromo-3-Chloropropane	40 MT	Sep 4, 2025

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