2-Bromoanil | Pharmaceutical Grade | 99.99% Purity | | Pharmaceutical Grade | 99.99% Purity | 10mg 20mg 30mg Vials | CAS 615-36-1

2-Bromoaniline Basic information
Description Chemical Properties Uses
Product Name:
2-Bromoaniline
Synonyms:
2-bromo-benzenamin;Aniline, o-bromo-;Benzenamine,2-bromo-;o-Aminobromobenzene;o-Chloroaceto-N-acetanilide;O-BROMOANILINE;2-BromoaniL;
CAS:
615-36-1
MF:
C6H6BrN
MW:
172.02
EINECS:
210-421-3
Product Categories:
amine | alkyl bromide;Amines;blocks;Bromides;Anilines, Aromatic Amines and Nitro Compounds;Miscellaneous;Anilines, Amides & Amines;Bromine Compounds;C2 to C6;Nitrogen Compounds;bc0001;Apinno
Mol File:
615-36-1.mol

2-Bromoaniline Chemical Properties
Melting point 
24-28 °C (lit.)
Boiling point 
229 °C (lit.)
density 
1.52 g/mL at 25 °C (lit.)
refractive index 
1.617-1.619
Fp 
>230 °F
storage temp. 
2-8°C
solubility 
0.949g/l
pka
2.53(at 25℃)
form 
Liquid After Melting
color 
Clear yellow to red-brown
Water Solubility 
Insoluble in water.
BRN 
742062
InChI
1S/C6H6BrN/c7-5-3-1-2-4-6(5)8/h1-4H,8H2
InChIKey
AOPBDRUWRLBSDB-UHFFFAOYSA-N
SMILES
Nc1ccccc1Br
CAS DataBase Reference
615-36-1(CAS DataBase Reference)
NIST Chemistry Reference
Benzenamine, 2-bromo-(615-36-1)
EPA Substance Registry System
Benzenamine, 2-bromo- (615-36-1)
Safety Information
Hazard Codes 
T,Xn
Risk Statements 
23/24/25-33-52/53-36/37/38-20/21/22-24/25
Safety Statements 
36/37-45-61-36/37/39-26
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
F 
8-23
Hazard Note 
Toxic
TSCA 
TSCA listed
HazardClass 
6.1
PackingGroup 
III
HS Code 
29214210
Storage Class
10 - Combustible liquids
Hazard Classifications
Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Aquatic Acute 1
Aquatic Chronic 1
STOT RE 2

MSDS Information
Provider
Language
o-Bromoaniline
English
SigmaAldrich
English
ACROS
English
ALFA
English
2-Bromoaniline Usage And Synthesis

Description
O-bromoaniline, m-bromoaniline and p-bromoaniline corresponds to the three isomers of bromoaniline. All of them three are toxic with its toxicity being more severe than chloroanilines. It can be all via percutaneous absorption, It is mainly used for dye raw materials, such as azo dyes, quinazoline dyes and so on. Heating together with glycerol, concentrated sulfuric acid and o-bromonitrobenzene can generate 8-bromoquinoline.
The preparation of the three isomers is as follows:
Take the corresponding nitroaniline as raw material, have it reacted with sodium nitrite in sulfuric acid, leading to the formation of diazonium salt, followed by reaction with hydrobromic acid under the action of cuprous bromide, leading to the formation of nitrobromobenzene, further subjecting to iron powder reaction in the bromic acid to generate the above three isomers.
Take benzene as raw material, under the action of iron powder, have it reacted with bromine to generate bromobenzene. It is then reacted with mixed acid (the mixture of sulfuric acid and nitric acid) to generate o-nitrobenzene and p-nitro bromobenzene (orthoaccounts of 35%; paraaccounts of 65%), so that the two are separated, followed by the same process as method one to generate o-bromoaniline and p-bromoaniline.
Take bromoacetanilide as raw material, put it into sodium hydroxide solution; apply water vapor reflux to obtain the bromoaniline.
Chemical Properties
It appears as white needle crystal with a melting point of 32 ° C, boiling point of 229 ° C, 138-141 ° C (6.38-6.92 kPa), 110.5 ° C (2.53 kPa), relative density of 1.578 (20/4 ° C) and a refractive index of 1.6133. It is soluble in alcohol and ether, but can’t be dissolved in water.

Uses
Organic synthesis intermediates
Chemical Properties
CLEAR YELLOW TO RED-BROWN LIQUID AFTER MELTING
Uses
2-Bromoaniline is used as a  It is used in the rubber industry, e.g. diphenylguanidines, phenylenediamines mercaptobenzothiazoles, aniline ketones and etc.
Synthesis
O-bromoaniline, m-bromoaniline and p-bromoaniline are the three isomers of bromoaniline, . Mainly used as raw material for dyes, such as azo dyes, quinazoline dyes, etc.. With glycerol, concentrated sulfuric acid and o-bromonitrobenzene heating to produce 8-bromoquinoline.
The three isomers are prepared as follows:
1, with the corresponding nitroaniline as raw material, in sulfuric acid and sodium nitrite reaction, the generation of diazonium salt, and then in the role of copper bromide, and hydrobromic acid reaction, the generation of nitro bromobenzene, and further in the hydrobromic acid with iron powder reduction; can be produced the above three kinds of isomers.
2, with benzene as raw material, under the action of iron powder, react with bromine to produce bromobenzene, and then react with mixed acid (mixture of sulfuric acid and nitric acid) to produce o-nitro bromobenzene and p-nitro bromobenzene (of which the neighboring position accounts for 35%, the p-position accounted for 65%), so that the two are separated, and then prepared according to method 1, can be produced o-bromoaniline and p-bromoaniline.
3, with p-bromoacetanilide as raw material, in sodium hydroxide solution, with water vapor reflux, can be produced p-bromoaniline.
2-Bromoaniline Preparation Products And Raw materials
Raw materials
2-Nitroaniline
Preparation Products
2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl-->->-->1,2-Dibromobenzene-->2'-BROMOACETANILIDE-->8-Bromoquinoline-->Tryptophol-->2-Bromophenylhydrazine hydrochloride-->12H- [1] benzothieno [2,3-a] carbazole-->Indolo[3,2,1-jk]carbazole-->6-BROMO-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONE-->4-(2-BROMO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER-->N-(TERT-BUTOXYCARBONYL)-2-BROMOANILINE-->2-PYRIDIN-2-YL-1H-INDOLE-->2-AMINOSTYRENE