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Retatrutide (LY3437943) acetate is a triple agonist peptide for the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R).

Retatrutide acetate inhibits human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643, and 0.775 nM, respectively. It exhibits activity on mouse GCGR, GIPR, and GLP-1R with EC50 values of 2.32, 0.191, and 0.794 nM, respectively.

In vivo, Retatrutide (LY3437943) acetate engages with GCGR and enhances glucose tolerance in an ipGTT by acting through GIP or GLP-1 receptors. Activation via the glucagon receptor by Retatrutide acetate leads to significant weight reduction and increased energy expenditure. Retatrutide acetate can be utilized in research related to obesity.

Retatrutide, LY3437943

CAS#: 2381089-83-2

Molecular Formula: C221H342N46O68

Molecular Weight: 4731.33

Sequence: H-Tyr-Aib-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-α-Me-Leu-Leu-Asp-Lys-{diacid-C20-gamma-Glu-(AEEA)-Lys}-Ala-Gln-Aib-Ala-Phe-Ile-Glu-Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2

Appearance: White Powder

Purity (HPLC): ≥99.0%

Single Impurity (HPLC): ≤1.0%

Sodium Content (HPLC): 5.0%-12.0%

Moisture Content (Karl Fischer): ≤10.0%

Peptide Content: ≥80.0%

RT stands for Retatrutide with the code name LY3437943. It is a popular third-generation metabolic research peptide in the industry. As a triple receptor agonist targeting GLP-1, GIP and GCGR, it is also a mainstream product in the current export research peptide sector. It is only applicable to in vitro laboratory and animal experimental research and must not be directly administered to humans (BioVe...).

Compared with dual-target peptide products, RT adds an activation pathway for glucagon receptors. The synergistic effect of three targets supports scientific experiments in multiple research directions including appetite regulation, blood glucose homeostasis, fat metabolism and hepatic lipid lesions. Its molecular structure is modified with long-chain fatty acids, delivering a longer half-life and compatibility with long-acting experimental models. Relevant Phase III clinical data highlight its prominent potential in metabolic regulation, leading to continuously rising procurement demand from overseas research institutions (peptideskn...).

The product is sterile white lyophilized powder individually packaged in vials. Main specifications cover 5mg, 10mg, 20mg and 60mg, with a standard configuration of 10 vials per box. Manufactured via solid-phase peptide synthesis, it maintains stable purity of ≥99% verified by HPLC testing. Endotoxin indicators are under strict control, and each batch is accompanied by a complete Certificate of Analysis (COA) for transparent and traceable component data, meeting quality inspection standards for overseas laboratories.

Clear specifications apply to storage conditions: the dry powder shall be hermetically stored away from light at -20°C with a shelf life of 24 months. After reconstitution with sterile pure water, the solution can be stored refrigerated at 2–8°C for 30 days; repeated freeze-thaw cycles shall be avoided to prevent activity loss. Neutral unlabeled white boxes are available for packaging, and exclusive custom labels for clients can be provided on demand. Sensitive terms such as injection and medical weight loss are fully excluded to reduce cross-border inspection risks.

Mature export shipment solutions are offered, supporting dedicated global logistics with stable channels covering Europe, America, Southeast Asia and the Middle East. Low-value declaration for customs clearance is available, and all shipments are marked "For Research Use Only". It features a low minimum order quantity, abundant in-stock inventory and short replenishment cycles; tiered pricing is accessible for long-term cooperative clients. Complete product documents and quality inspection certificates are provided to assist clients with local laboratory filing. It serves as a core raw material widely adopted in overseas metabolic research projects.

Storage: Store at 2-8 degrees Celsius in a dry and cool place.

Packaging: 5mg/vial 10vials/box

Intended Use: For scientific research purposes