—— Product Specifications ——
Parameter | Specification | Details / Test Method |
Purity (HPLC) | ≥98% | High Performance Liquid Chromatography, area % |
Moisture Content | ≤1.0% | Karl Fischer titration method |
Heavy Metals | <10 ppm | ICP-MS method, max 10 ppm as Pb |
Residual Solvents | Complies with ICH limits | Headspace GC-MS method, ICH Q3C guidelines |
IC50 (BRD4) | 39 nM | Standard test method for ic50 (brd4) |
Appearance | White to yellow powder | Visual inspection at room temperature |
Solubility | DMSO: 10 mM | Tested in various solvents at 25°C |
Storage Temperature | -20°C or 2-8°C | Store in cool, dry place, protected from light |
Molecular Formula | C22H21ClN2O2 | Calculated from molecular structure |
Molecular Weight | 380.87 g/mol | Calculated from molecular formula |
Product Name | NVP-2 | Identified by COA and batch record |
CAS Number | 1263373-43-8 | Verified by supplier documentation |
—— Product Detail ——
Product Overview
NVP-2 is a potent and selective bromodomain-containing protein 4 (BRD4) inhibitor with an IC50 of approximately 39 nM. It targets the acetyl-lysine binding site of bromodomains, effectively disrupting protein-protein interactions critical for cancer cell proliferation. BRD4 is a member of the BET (bromodomain and extra-terminal) family, which plays a crucial role in transcriptional regulation and has been implicated in various cancers including leukemia, lymphoma, and solid tumors. NVP-2 demonstrates high binding affinity for BRD4 and exhibits antiproliferative effects in cancer cell lines. This compound serves as an important research tool in cancer biology and drug discovery, enabling studies on the role of BET proteins in disease pathogenesis and therapeutic targeting.
Synthesis Process
NVP-2 is synthesized through a multi-step organic synthetic route starting from commercially available building blocks. The key synthetic steps involve a Suzuki-Miyaura coupling reaction to form the central biaryl linkage, followed by amide bond formation using standard peptide coupling reagents. The final step includes chiral resolution or asymmetric synthesis to obtain the optically pure compound. The crude product is purified using reversed-phase HPLC with gradient elution, and the fractions containing the target compound are lyophilized to obtain the final product as a solid powder.
Quality Specifications
The product meets the following specifications: purity ≥98% as determined by HPLC at 254nm; moisture content ≤1.0%; residual solvents within ICH limits; heavy metals <10ppm. Each batch is accompanied by a Certificate of Analysis including HPLC, 1H-NMR, 13C-NMR, MS, and elemental analysis data. The compound is verified to be the correct structure through mass spectrometry and nuclear magnetic resonance spectroscopy.
Packaging & Storage
NVP-2 is packaged in sealed amber glass vials or foil-lined bags with desiccant inside. The product should be stored at -20°C or 2-8°C in a dry, dark environment. Keep container tightly closed when not in use. For laboratory use only; handle with appropriate personal protective equipment. Avoid exposure to moisture, heat, and light.
— C ompany Profile ——
Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.
Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.
We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.
To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.
Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.
—— Q&A ——
Q1: How to confirm the product quality before placing orders?
A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.
Q2: Can you supply free samples?
A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.
Q3: How do you treat quality complaints?
A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.
Q4: What is your MOQ? Is there a discount?
A: For high value products, our MOQ starts from 1g and generally starts from 10g. For other low price products, our MOQ starts from 100g and 1kg.
Q: Is there a discount?
A: Yes, for larger quantities, we always support with better prices.
Q5: How to start orders or make payments?
A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.
