—— Product Specifications ——

—— Product Detail ——

Product Overview

1H-1,2,4-Triazol-5-ylacetic Acid is a heterocyclic building block featuring a 1,2,4‑triazole ring substituted at the 5‑position with an acetic acid moiety. This compound is a white to off‑white powder with a molecular formula of C4H5N3O2 and a molecular weight of approximately 127.12 g/mol. Its unique structure provides a reactive carboxyl group and a triazole nitrogen system, making it a valuable intermediate in the synthesis of pharmaceuticals, agrochemicals, and functional materials. The product is supplied with a guaranteed purity of ≥98 % as determined by HPLC, low moisture content, and stringent heavy‑metal controls, ensuring consistent performance in research and industrial scale‑up. It is compatible with common organic solvents such as dimethyl sulfoxide, N,N‑dimethylformamide, and methanol, facilitating its incorporation into multi‑step synthetic routes. The compound is typically used in the construction of triazole‑based APIs, enzyme inhibitors, and novel ligands. Each batch is rigorously tested and accompanied by a certificate of analysis that includes purity, loss on drying, residual solvents, and assay results. Our packaging options range from 1 kg aluminum foil bags to 25 kg paper drums, allowing flexibility for different volume requirements. Handling should be performed in a well‑ventilated fume hood, wearing appropriate protective gloves and safety glasses. The compound is supplied with detailed MSDS to ensure safe transport and storage.

Synthesis Process

The synthesis of 1H‑1,2,4‑triazol‑5‑ylacetic acid begins with the N‑alkylation of 1,2,4‑triazole with chloroacetic ester in the presence of a base, forming the N‑triazolyl acetate intermediate. This intermediate is subsequently hydrolyzed under alkaline conditions to afford the free carboxylic acid. The crude product is then purified by recrystallization from ethanol‑water or by ion‑exchange chromatography, delivering the target compound with purity exceeding 98 % (HPLC). Alternative protocols employ palladium‑catalyzed cross‑coupling of 5‑bromo‑1,2,4‑triazole with an organoboron acetate, followed by hydrolysis, which can improve overall yield. Strict control of reaction temperature, pH, and work‑up conditions minimizes side reactions and ensures reproducible quality.

Quality Specifications

The product complies with the following specifications: assay (HPLC) ≥98.0 %; loss on drying ≤0.5 %; heavy metals (Pb) ≤10 ppm; residual solvents (DMSO, MeOH) ≤0.5 % each; pH of a 1 % aqueous solution 2.5–3.5; melting point 215–217 °C; solubility in DMSO ≥50 mg/mL. Identity is confirmed by IR, NMR, and MS. Each batch is accompanied by a Certificate of Analysis stating all test results. The material meets Pharmaceutical Grade requirements and is suitable for use in GMP manufacturing processes. Stability studies show no degradation after 12 months at 40°C/75% RH, supporting a shelf life of 24 months when stored as recommended.

Packaging & Storage

Store the compound in a tightly sealed container in a cool, dry place. Recommended temperature is 2–8 °C; avoid exposure to moisture and direct sunlight. Keep away from strong oxidizers and acidic or basic substances. When handling, use gloves, safety glasses, and work in a fume hood. The product has a shelf life of 24 months from the date of manufacture when stored under the specified conditions. Transport complies with UN proper shipping names for non‑hazardous chemicals.

— C ompany Profile ——

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

—— Q&A ——

Q1: How to confirm the product quality before placing orders?
A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

Q2: Can you supply free samples?
A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

Q3: How do you treat quality complaints?
A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

Q4: What is your MOQ? Is there a discount?
A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
Q: Is there a discount?
A: Yes, for larger quantities, we always support with better prices.

Q5: How to start orders or make payments?
A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.