—— Product Specifications ——

—— Product Detail ——

Product Overview

3-Bromo-5-fluoroquinoline is a halogenated quinoline derivative with both bromo and fluoro substituents on the quinoline ring. This compound features a unique combination of halogen atoms that make it particularly valuable in pharmaceutical research and organic synthesis. The bromo group at position 3 and fluoro group at position 5 provide specific reactive sites for further functionalization through various coupling reactions, including Suzuki, Negishi, and other metal-catalyzed cross-coupling reactions. As a pharmaceutical intermediate, this compound serves as a key building block in the synthesis of various bioactive quinoline-based drug candidates. The electron-withdrawing nature of both halogen substituents affects the electronic properties of the heterocyclic system, making it useful for developing compounds with specific pharmacological activities.

Synthesis Process

The synthesis of 3-bromo-5-fluoroquinoline typically involves multi-step procedures starting from commercially available quinoline or substituted aniline derivatives. One common approach involves the preparation of 5-fluoroquinoline followed by selective bromination at the 3-position using N-bromosuccinimide (NBS) under controlled conditions. Alternatively, the compound can be synthesized through the Friedländer quinoline synthesis using 2-aminobenzaldehyde or its derivatives with appropriate bromo and fluoro substituents. The reaction conditions are optimized to ensure selective halogenation and minimize side reactions. After the final step, the product is purified through column chromatography and recrystallization to achieve the desired purity level.

Quality Specifications

This product meets research grade specifications with a minimum purity of 97% as determined by HPLC. The compound has a melting point range of 95-98°C. Residual solvents and moisture content are controlled below 0.5%. Heavy metals are limited to less than 10 ppm. The product is characterized by 1H NMR, 13C NMR, and mass spectrometry to confirm structural identity and purity. Each batch comes with a Certificate of Analysis (COA) detailing all quality parameters and testing methods used.

Packaging & Storage

The product is packaged in amber glass bottles with sealed caps and tamper-evident seals. For short-term storage, keep the container tightly closed and store in a cool, dry place away from direct sunlight and moisture. For long-term storage, maintain at 2-8°C under inert atmosphere. Handle with appropriate personal protective equipment (PPE) including gloves, safety glasses, and lab coat. Avoid inhalation and skin contact during handling.

—— C ompany Profile ——

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

—— Q&A ——

Q1: How to confirm the product quality before placing orders?
A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

Q2: Can you supply free samples?
A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

Q3: How do you treat quality complaints?
A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

Q4: What is your MOQ? Is there a discount?
A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
Q: Is there a discount?
A: Yes, for larger quantities, we always support with better prices.

Q5: How to start orders or make payments?
A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.