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Home > Chemical Reagents > Organic Reagents > Acetyl chloride for Sale > Acetyl Chloride CAS 75-36-5 99% Acylating Reagent for Pharmaceutical Agrochemical Dye Synthesis Organic Intermediate
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Acetyl Chloride CAS 75-36-5 99% Acylating Reagent for Pharmaceutical Agrochemical Dye Synthesis Organic Intermediate

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Unit Price:

$10-13/G FOB

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CAS No.:

75-36-5

Grade:

Research Grade

Content:

99%

Port:

qingdao

Brand:

//

Packaging:

1g/vial, 5g/vial, 10g/vial, 25g/vial

Price valid (until):

2026-08-01

Company Type:
Trader
Location:
China
Qualification:
Main Products:

3-(1-Naphthoyl)indole

  • Product Description

  • Seller Information

  • Inquiry History

  • Description

    —— Product Specifications ——

    Appearance Colorless to light yellow clear fuming liquid 
    Odor Pungent, irritating 
    Melting Point -112°C 
    Boiling Point 50.9 - 52°C 
    Flash Point 4 - 5°C (closed cup) 
    Density (20°C) 1.104 - 1.109 g/cm³ 
    Refractive Index (20°C) 1.3875 - 1.3915 
    Solubility Miscible with benzene, acetone, chloroform, ether, glacial acetic acid, petroleum ether; decomposes in water and alcohol 
    Sensitivity Moisture sensitive; decomposes with water

    —— Product Detail ——

    Product Overview

    Product Name: Acetyl Chloride (Chloracetyl)

    CAS No.: 75-36-5

    Molecular Formula: C₂H₃ClO (CH₃COCl)

    Molecular Weight: 78.50

    EINECS No.: 200-865-6

    Synonyms: Chloracetyl, Chloroacetyl, Acetic Chloride, Ethanoyl Chloride


    Acetyl Chloride (CAS 75-36-5) is a colorless to light yellow clear fuming liquid with a pungent, irritating odor . It is a highly reactive acyl chloride derived from acetic acid, with a molecular weight of 78.50. The compound is flammable, moisture-sensitive, and decomposes violently upon contact with water or alcohol .

    With a purity of ≥99.0%, Acetyl Chloride serves as one of the most important acylating reagents in organic synthesis. Its strong electrophilic acetylating capability makes it a versatile building block for introducing acetyl groups into various organic molecules



    Key Applications:

    1. Pharmaceutical Synthesis (Primary Application)

    Acetyl Chloride is a key raw material for the synthesis of various pharmaceutical compounds, including:

    • 2,4-Dichloro-5-fluoroacetophenone (an intermediate for Ciprofloxacin)

    • Ibuprofen

    • Other antibiotic and anti-inflammatory drug intermediates 

    2. Organic Synthesis & Acetylation

    Acts as a powerful acetylating reagent for introducing acetyl groups into alcohols, amines, and aromatic compounds. Its acylating capability is stronger than acetic anhydride, making it preferred for many acetylation reactions .

    3. Agrochemical Industry

    Used in the production of pesticides, herbicides, and other agrochemical intermediates .

    4. Dye Industry

    Serves as a starting material for the synthesis of various dyes and pigments .

    5. Industrial Applications

    • Catalyst for chlorination reactions of carboxylic acids

    • Production of novel electroplating complexing agents

    • Fine chemical synthesis and specialty organic intermediates 

    6. Analytical Chemistry

    • Reagent for the determination of cholesterol and water content in organic liquids

    • Hydroxy and amino group quantitative analysis



    —— Chemical Properties ——



    Property Value
    Appearance Colorless to light yellow clear fuming liquid 
    Odor Pungent, irritating 
    Melting Point -112°C 
    Boiling Point 50.9 - 52°C 
    Flash Point 4 - 5°C (closed cup) 
    Density (20°C) 1.104 - 1.109 g/cm³ 
    Refractive Index (20°C) 1.3875 - 1.3915 
    Solubility Miscible with benzene, acetone, chloroform, ether, glacial acetic acid, petroleum ether; decomposes in water and alcohol 
    Sensitivity Moisture sensitive; decomposes with water

     

     

    Packaging & Storage

    Packed in 200kg/plastic drum or steel drum . Store in a cool, dry, well-ventilated warehouse away from fire, heat, and direct sunlight. Keep container tightly sealed and strictly protect from moisture. Store under inert gas such as nitrogen to prevent degradation. Shelf life: 12 months under proper storage conditions.

    c ompany Profile ——


     Shop Acetyl Chloride CAS 75-36-5 99% Acylating Reagent for Pharmaceutical Agrochemical Dye Synthesis Organic Intermediate-Detailed Image 1

    Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

    Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

    We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

    To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

    Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

     

    Shop Acetyl Chloride CAS 75-36-5 99% Acylating Reagent for Pharmaceutical Agrochemical Dye Synthesis Organic Intermediate-Detailed Image 2

    Shop Acetyl Chloride CAS 75-36-5 99% Acylating Reagent for Pharmaceutical Agrochemical Dye Synthesis Organic Intermediate-Detailed Image 3 

    —— Q&A ——

    Q1: How to confirm the product quality before placing orders?
    A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

    Q2: Can you supply free samples?
    A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

    Q3: How do you treat quality complaints?
    A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

    Q4: What is your MOQ? Is there a discount?
    A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
    Q: Is there a discount?
    A: Yes, for larger quantities, we always support with better prices.

    Q5: How to start orders or make payments?
    A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly,we accept usd,.usdt,alipay,wechat pay and cash. If you have other preferred payment methods, we are open to discussion and negotiation.



    Shop Acetyl Chloride CAS 75-36-5 99% Acylating Reagent for Pharmaceutical Agrochemical Dye Synthesis Organic Intermediate-Detailed Image 4

    Certificates
    • Acetyl Chloride CAS 75-36-5 99% Acylating Reagent for Pharmaceutical Agrochemical Dye Synthesis Organic Intermediate Certificates 1

    Basic Info
    Product Name:

    Acetyl chloride

    Other Name:

    Acetyl chloride;Ethanoyl chloride;Acetic chloride;Acetic acid chloride

    CAS No.:

    75-36-5

    Molecular Formula:

    C2H3ClO

    InChIKeys:

    InChIKey=WETWJCDKMRHUPV-UHFFFAOYSA-N

    Molecular Weight:

    78.5

    Exact Mass:

    78.50

    BRN:

    605303

    EC Number:

    200-865-6

    UNII:

    QD15RNO45K

    ICSC Number:

    0210

    UN Number:

    1717

    DSSTox ID:

    DTXSID2023852

    Color/Form:

    Liquid|Colorless fuming liquid

    HScode:

    2915900090

    Categories:

    Organic Reagents

    Characteristics
    PSA:

    17.1

    XLogP3:

    -0.47

    Appearance:

    Clear colorless Liquid

    Density:

    1.1051 g/cm3 @ Temp: 20 °C

    Melting Point:

    -112 °C

    Boiling Point:

    52 °C

    Flash Point:

    40 °F

    Refractive Index:

    1.379

    Water Solubility:

    Miscible with acetone, chloroform, glacial acetic acid, petroleum ether, ether and benzene.

    Storage Conditions:

    Store at RT

    Vapor Pressure:

    11.69 psi ( 20 °C)

    Vapor Density:

    2.7 (vs air)

    Toxicity:

    Oral-Rat LD50: 910 mg/kg

    Flammability characteristics:

    Inflammable in case of fire, high temperature and oxidant; decomposes toxic phosgene in high heat; emits toxic chloride fumes in water

    Explosive limit:

    7.3-19%(V)

    Odor:

    Pungent odor

    OH:

    9.10e-15 cm3/molecule*sec

    Experimental Properties:

    Decomposed violently by water or alcohol|Highly refractive|Ratio of specific heats of vapor (gas): 1.1467|Liquid heat capacity: 0.350 Btu/lb-F at 70 °F|For more Other Experimental Properties (Complete) data for Acetyl chloride (8 total), please visit the HSDB record page.

    Air and Water Reactions:

    Highly flammable. Fumes in air. Reacts violently with water producing heat and acidic HCl [Merck 11th ed. 1989]. Acetyl chloride reacts vigorously with water to generate gaseous HCl. Based on a scenario where the chemical is spilled into an excess of water (at least 5 fold excess of water), half of the maximum theoretical yield of Hydrogen Chloride gas will be created in 0.11 minutes. Experimental details are in the following: "Development of the Table of Initial Isolation and Protective Distances for the 2008 Emergency Response Guidebook", ANL/DIS-09-2, D.F. Brown, H.M. Hartmann, W.A. Freeman, and W.D. Haney, Argonne National Laboratory, Argonne, Illinois, June 2009.

    Reactive Group:

    Acyl Halides, Sulfonyl Halides, and Chloroformates

    Reactivity Alerts:

    Highly Flammable

    Reactivity Profile:

    ACETYL CHLORIDE reacts violently with water, steam, methanol or ethanol to form hydrogen chloride and acetic acid. Reacts vigorously with bases, both organic and inorganic. Incompatible with oxidizing agents and alcohols. Produces highly toxic fumes of phosgene gas and chlorine when heated to decomposition [Sax, 9th ed., 1996, p. 35]. Reaction in a confined space with even a small amount of water may cause a violent eruption of gases [Bretherick, 5th ed., 1995, p. 281]. Vapor forms an explosive mixture with air [Kirk-Othmer, 3rd ed., Vol. 1, 1978, p. 162]. Polymerization reaction with dimethyl sulfoxide is particularly violent [Buckley, A., J. Chem. Ed., 1965, 42, p. 674]. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

    Autoignition Temperature:

    734 °F (USCG, 1999)|734 °F (390 °C)|390 °C

    Heat of Combustion:

    -6,000 btu/lb = -3,000 cal/g = -140X10X5 J/kg

    Flammable Limits:

    Lower: 5.0% by volume

    Physical Dangers:

    The vapour is heavier than air and may travel along the ground; distant ignition possible.

    Corrosivity:

    Corrosive|Corrosive to metals and tissue

    Heat of Vaporization:

    160 btu/Lb = 88 cal/g = 3.7X10X5 J/kg

    Critical Temperature & Pressure:

    Critical temperature: 475 °F = 246 °C = 519 deg K; Critical pressure: 845 psia = 57.5 atm = 5.83 MN/sq m

    Hazard Identification

    Classification of the substance or mixture

    Flammable liquids, Category 2

    Skin corrosion, Sub-category 1B

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Danger

    Hazard statement(s)

    H225 Highly flammable liquid and vapour

    H314 Causes severe skin burns and eye damage

    Precautionary statement(s)
    Prevention

    P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

    P233 Keep container tightly closed.

    P240 Ground and bond container and receiving equipment.

    P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment.

    P242 Use non-sparking tools.

    P243 Take action to prevent static discharges.

    P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

    P260 Do not breathe dust/fume/gas/mist/vapours/spray.

    P264 Wash ... thoroughly after handling.

    Response

    P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse affected areas with water [or shower].

    P370+P378 In case of fire: Use ... to extinguish.

    P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

    P363 Wash contaminated clothing before reuse.

    P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

    P316 Get emergency medical help immediately.

    P321 Specific treatment (see ... on this label).

    P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

    Storage

    P403+P235 Store in a well-ventilated place. Keep cool.

    P405 Store locked up.

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    NO open flames, NO sparks and NO smoking. NO contact with hot surfaces. Closed system, ventilation, explosion-proof electrical equipment and lighting. Prevent build-up of electrostatic charges (e.g., by grounding). Do NOT use compressed air for filling, discharging, or handling. Use non-sparking handtools. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Fireproof. Separated from incompatible materials. See Chemical Dangers. Dry. Well closed.Separate from alcohols, alkalies, amines, and strong oxidizing materials. Store in a cool, dry well-ventilated location. Outside or detached storage is preferred. Inside storage should be in a standard flammable liquids storage warehouse, room, or cabinet.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    3-(1-Naphthoyl)indole

    Location:

    RONGSHENG BEIYUANDAJIE 9, LICHENG DISTRICT,JINAN, SHANDONG CHINA

    Year of Establishment:

    2022

    Jinan Topfull Chemical Co., Ltd. is a global chemical Industrial and focuses on advanced chemical technology. Specialized in Cosmetic materials, water treatment, fine chemicals and so on. We are looking forward to working together with the people of all circles at home and abroad to seek common development!
  • Inquiry History
    4 Inquiries
    Country Product Purchase Quantity Date Posted
    Thailand

    Acetyl chloride

    200 KG Oct 11, 2023
    Canada

    Acetyl chloride

    100 G Jun 15, 2026
    Bangladesh

    Hot selling high quality paracetamol 99% white powder 103-90-2 Ainuodi

    70 MT Oct 20, 2023
    Romania

    Hot selling high quality paracetamol 99% white powder 103-90-2 Ainuodi

    10000 MT Aug 28, 2023
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