—— Product Specifications ——

—— Product Detail ——

Product Overview

MI-503 is a high-purity pharmaceutical intermediate supplied as a white powder. It is a selective inhibitor of the anti-apoptotic protein Mcl-1, a member of the Bcl-2 family, and is used primarily in preclinical oncology research. The compound is synthesized through a multi-step organic route featuring a Suzuki coupling, followed by deprotection and crystallization steps. Final purification by reversed-phase HPLC yields a purity of ≥98% as determined by HPLC, meeting the stringent standards required for pharmaceutical intermediates. The product is packaged in amber glass bottles under nitrogen atmosphere to ensure stability and to protect from light and moisture. It is recommended to store the material at 2-8°C in a dry environment, away from direct sunlight. The compound is for research use only and is not intended for human or animal therapeutic applications. Various pack sizes (1 g, 5 g, 10 g, 25 g) are available to accommodate different research needs. All batches are tested for moisture, residual solvents, and heavy metals in accordance with ICH guidelines, ensuring consistent quality and performance in experimental settings. The compound's mechanism of action involves binding to the BH3 domain of Mcl-1, thereby disrupting its interaction with pro-apoptotic proteins such as Bak and Bax, leading to mitochondrial outer membrane permeabilization and apoptosis induction in cancer cells. Research studies have demonstrated that MI-503 can synergize with standard chemotherapeutic agents, enhancing their efficacy in cell viability assays. The product is manufactured in ISO-certified facilities, and each lot is accompanied by a certificate of analysis that includes detailed test results and analytical methods.

Synthesis Process

The synthesis of MI-503 begins with the Suzuki-Miyaura coupling of a substituted heteroaryl halide with an appropriate boronic acid derivative, yielding the core biphenyl motif. After the coupling, the intermediate is subjected to a deprotection step to remove the Boc protecting group, followed by a cyclization reaction to form the final heterocyclic scaffold. The crude product is then purified by silica-gel column chromatography and recrystallized from a mixture of ethyl acetate and hexane. The final crystalline solid is dried under reduced pressure, analyzed by HPLC for purity, and packaged under nitrogen. This route provides an overall yield of approximately 30-40% and consistently delivers product with >98% purity.

Quality Specifications

Each batch of MI-503 is tested for purity by HPLC (≥98%), moisture content (<0.5%), loss on drying (<0.5%) and residual solvents (ethanol <0.5%, acetone <0.3%). Heavy metal analysis is performed by ICP-MS, with limits conforming to ICH Q3D guidelines. The melting point is recorded at 200-205°C and the compound shows excellent solubility in DMSO, moderate solubility in methanol, and negligible solubility in water. The certificate of analysis includes all test results, method validation data, and a reference sample for cross-verification. All results must meet the predefined acceptance criteria before release.

Packaging & Storage

MI-503 should be stored in a tightly sealed amber glass bottle, placed inside a desiccator or sealed aluminum foil bag to protect from light and moisture. For long-term storage, keep the material at 2-8°C; short-term storage at room temperature (15-25°C) is acceptable for up to one month. Avoid exposure to temperatures above 40°C or to direct sunlight. When handling, use inert atmosphere (e.g., nitrogen) to prevent oxidation. Keep out of reach of children and away from incompatible substances such as strong acids or bases.

—— C ompany Profile ——

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

—— Q&A ——

Q1: How to confirm the product quality before placing orders?
A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

Q2: Can you supply free samples?
A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

Q3: How do you treat quality complaints?
A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

Q4: What is your MOQ? Is there a discount?
A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
Q: Is there a discount?
A: Yes, for larger quantities, we always support with better prices.

Q5: How to start orders or make payments?
A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.