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- Product Name: PNC-27 Chimeric Anti-Cancer Peptide
- CAS No.: 1159861-00-3
- Amino Acid Sequence: H-PPLSQETFSDLWKLLKKWKMRRNQFWVKVQRG-OH
- Peptide Length: 32 amino acids
- Molecular Formula: C₁₈₈H₂₉₃N₅₃O₄₄S
- Molecular Weight: 4031.71 Da
- Purity: ≥99% HPLC High Purity, single impurity ≤0.3%
- Appearance: White sterile lyophilized fine powder
- Grade: Professional Research Grade, ultra-low endotoxin, stable biological activity
- Available Specifications: 5mg/vial, 10mg/vial, 25mg/vial, bulk powder customizable
- Packaging: Sterile glass vial with rubber stopper & aluminum crimp cap; bulk vacuum foil bag
- Solubility: Fully soluble in bacteriostatic sterile water, clear transparent solution
- Mechanism: Selectively target membrane HDM-2/MDM2 on tumor cells, form transmembrane pores to induce cancer cell necrosis, p53-independent pathway
- Supply Advantage: Direct factory supply, favorable wholesale price, abundant ready stock, full set test documents
- Storage Condition: Long-term storage at -20℃, sealed light & moisture proof, avoid repeated freeze-thaw cycles
- Attached Documents: Complete COA, HPLC, Mass Spectrum, heavy metal, microbial & endotoxin test reports
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| Category | Peptides | CAS | 1159861-00-3 |
| Bottle Color | Transparent | Model |
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| Purity | 99% | Storage | Dry Cool Sealed Container |
| Specification | 5MG,10MG | Form | Lyophilized Powder(Freeze-Dried Powder) |
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PNC-27 chimeric anti-cancer peptide CAS 1159861-00-3 is high purity lyophilized research peptide with ≥99% HPLC purity, supplied directly by peptide manufacturer with favorable factory price and sufficient ready stock for global wholesale.
This 32-residue synthetic peptide combines p53 HDM2-binding domain and cell-penetrating sequence, featuring highly selective tumor-killing capacity independent of p53 function:
- Specific HDM2 targeting: HDM2 overexpresses on plasma membrane of solid tumors and leukemia cells, while normal cells only retain HDM2 intracellularly, so PNC-27 spares healthy cells completely;
- Pore-forming necrosis pathway: After binding membrane HDM2, PNC-27 oligomerizes to form ring-shaped transmembrane pores, disrupting cell membrane and mitochondrial membrane to trigger rapid tumor cell death within several hours, effective for p53-null cancer cell lines such as K562 leukemia;
- Wide research usage: In-vitro anti-tumor efficacy assay, HDM2 tumor biomarker research, oncolytic peptide pre-drug development, targeted drug delivery carrier and combined anti-cancer therapy model study.
The white lyophilized powder dissolves fully in bacteriostatic water with stable biological activity and repeatable lab data. We provide standard vial specifications (5mg,10mg,25mg) and large bulk powder, custom private label packaging is available. Every batch comes with complete COA, HPLC and MS test certificates, fully compliant with international research peptide export standards.
Disclaimer: This product is for laboratory anti-cancer research only, prohibited for human clinical cancer treatment, injection or oral administration.
Q1: Are you a supplier or a manufacturer?
A: We are both a supplier and a manufacturer.
Q2: How do you make the delivery?
A: We have established stable cooperative relationships with DHL, TNT, UPS, FedEx, EMS, China Post Air Express, etc. For container transportation, we can arrange for sea shipping; you can also choose your own freight forwarder.
Q3: What payment methods do you accept?
A: We accept Bitcoin and USDT.
Q4: How about the after-sales service?
A: We offer high-quality products and guarantee 100% safe delivery.
Q5: How do you ensure product quality?
A: We will send you the analysis report (COA) of the sample to confirm the quality.
Q6: How can we verify the quality of the products before placing an order?
A: For some products, free samples are available. You only need to bear the shipping cost or arrange for a courier to pick them up. You can also provide the product specifications and requirements, and we will produce them accordingly.
Q7: Are there any discount offers?
A: Yes, the larger the order quantity, the more favorable the price will be .
Company Profile: Tianjin Huifeng Technology Co., Ltd. is a company specializing in the production of various peptide products and chemical raw materials. We have a professional R&D team and an efficient and reliable logistics team to ensure that you can receive high-quality products safely and on time. Our customers are located in the United States, Europe, Japan, South Korea, India, and other regions. Most of our main products are in stock and can be shipped immediately. Please inform us of your specific quantity requirements, and we will provide you with the most competitive prices. Welcome to contact us at any time for more information.
We offer a wide range of peptide products, which are widely used in life science research, drug development, cosmetics, anti-aging medicine, and functional health supplements. We guarantee excellent product quality and competitive prices. Customers who have ordered our peptide products have always given high evaluations. We sincerely welcome reliable buyers from all over the world to contact us and negotiate business cooperation for peptide products.
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