5-Bromo-4-hydroxynicotinaldehyde CAS 1289109-05-2 98% Pharmaceutical Intermediate API Impurity Standard

1. Product Overview

5-Bromo-4-hydroxynicotinaldehyde (CAS: 1289109-05-2) is a high-purity brominated pyridine derivative widely used as a key intermediate in pharmaceutical synthesis and as a reference standard for Nicergoline-related impurities. With its well-defined molecular structure and excellent batch-to-batch consistency, it is an essential building block for R&D laboratories and pharmaceutical manufacturers.

2. Key Features and Advantages

• High Purity: ≥98% purity, suitable for sensitive pharmaceutical applications

• Well-Characterized: Fully validated by NMR, HPLC, and mass spectrometry

• Stable Supply: Reliable production capacity with consistent quality control

• Regulatory Compliance: Meets international standards for pharmaceutical intermediates

• Flexible Packaging: Available in various quantities from R&D scale to bulk orders

3. Main Applications

• Pharmaceutical Intermediate: Serves as a crucial intermediate in the synthesis of nicergoline and related ergoline derivatives

• API Impurity Standard: Used as a reference standard for impurity profiling and method development in pharmaceutical quality control

• Organic Synthesis: Acts as a versatile building block in the construction of heterocyclic compounds

• Research & Development: Supports medicinal chemistry research in CNS-active compounds

4. Technical Specifications

5. Storage and Handling

• Store in a cool, dry place at 2–8°C, away from direct sunlight and moisture

• Keep container tightly sealed when not in use

• Use in a well-ventilated area with appropriate personal protective equipment (PPE)

• Avoid contact with strong oxidizing agents and incompatible materials

• For long-term storage, consider packaging under inert atmosphere (N₂ or Ar) to maintain optimal stability

6. Safety Overview

• Hazard Classification: Irritant — may cause skin and eye irritation upon contact

• Precautionary Measures: Wear suitable protective gloves, safety goggles, and laboratory coat during handling

• First Aid: In case of skin contact, wash immediately with plenty of water; for eye contact, rinse thoroughly and seek medical advice

• Disposal: Dispose of in accordance with local, regional, and national regulations for chemical waste

• Regulatory Status: Not listed as a hazardous substance under REACH/GHS regulations; standard laboratory chemical handling protocols apply

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