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99% Pure Carboplatin CAS 41575-94-4 High-Purity Antineoplastic Platinum Raw Material | USP/EP Anticancer API buy - image1

99% Pure Carboplatin CAS 41575-94-4 High-Purity Antineoplastic Platinum Raw Material | USP/EP Anticancer API buy - image2

99% Pure Carboplatin CAS 41575-94-4 High-Purity Antineoplastic Platinum Raw Material | USP/EP Anticancer API buy - image3

99% Pure Carboplatin CAS 41575-94-4 High-Purity Antineoplastic Platinum Raw Material | USP/EP Anticancer API buy - image4

99% Pure Carboplatin CAS 41575-94-4 High-Purity Antineoplastic Platinum Raw Material | USP/EP Anticancer API

Name: 99% Pure Carboplatin CAS 41575-94-4 High-Purity Antineoplastic Platinum Raw Material | USP/EP Anticancer API
Brand: HyperChem
SKU: pr2608052822
Price: 85 USD
Availability: InStock

TDS 11 Inquiries

Unit Price:

$85-110/G FOB

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CAS No.:

41575-94-4

Grade:

Pharmaceutical Grade

Content:

99.9%

Port:

Hangzhou

Brand:

HyperChem

Packaging:

1kg/bag, 5kg/bag, 25kg/Drum

Price valid (until):

2029-01-31

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
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Inquiry History

Description

Name	Carboplatin
CAS number	41575-94-4
Synonym	Carboplatin API; CAS 41575-94-4; Antineoplastic Raw Material Carboplatin; Pharma Grade Carboplatin Powder Carboplatin; USP EP GMP Carboplatin Carboplatin; Oncology API Bulk Supply Carboplatin; Paraplatin Alternative API Carboplatin; White Crystalline Carboplatin; Chemo Formulation Base Material Carboplatin; Carboplatin for Pharma Manufacturing
Related APIs #	Cisplatin — CAS 15663-27-1 Oxaliplatin — CAS 61825-94-3 Nedaplatin — CAS 154697-91-3 Lobaplatin — CAS 149877-81-8 Heptaplatin — CAS 146665-77-2 Satraplatin — CAS 129580-63-8 Picoplatin — CAS 170510-67-3 Miriplatin — CAS 250159-48-9 Ormaplatin (Tetraplatin) — CAS 62816-98-2 Dicycloplatin — CAS 287402-09-9
Description	Carboplatin: A Comprehensive Overview of an Advanced Antineoplastic Platinum-Based Agent Carboplatin stands as a pivotal therapeutic agent in contemporary oncology, renowned for its efficacy and improved tolerability profile compared to earlier platinum-based compounds. As a second-generation platinum analog, it has fundamentally reshaped treatment paradigms for various solid malignancies, offering clinicians a robust tool characterized by predictable pharmacokinetics and a distinct safety margin. This overview delineates its pharmacological effects, mechanisms of action, physicochemical attributes, and clinical utility, adhering strictly to professional and regulatory standards. Pharmacological Effects and Clinical Utility Carboplatin exerts profound cytotoxic effects primarily against rapidly dividing cells, making it exceptionally effective in managing advanced carcinomas. Its clinical spectrum encompasses first-line and recurrent ovarian cancer, where it often forms the backbone of combination regimens. Additionally, it demonstrates significant activity against small-cell and non-small-cell lung carcinomas, head and neck squamous cell cancers, germ cell tumors, and bladder malignancies. The agent’s therapeutic index is notably favorable; while maintaining potent antitumor efficacy, it substantially reduces the severity of certain adverse reactions commonly associated with its predecessors, particularly acute emetogenesis and nephrotoxicity. This allows for outpatient administration and enhanced patient compliance, critical factors in chronic disease management. Mechanism of Action: DNA Adduct Formation and Apoptosis At the molecular level, Carboplatin operates as a cell-cycle nonspecific alkylating-like agent. Its mechanism is predicated on the aquation process—a slow displacement of its cyclobutane dicarboxylate ligand upon cellular uptake, facilitated by relatively low chloride ion concentrations inside the cell. This activation yields highly reactive aqua species capable of forming covalent bonds with nucleophilic sites on DNA. Primarily, it creates intrastrand cross-links between adjacent guanine residues (1,2-d(GpG) adducts), although interstrand links and DNA-protein cross-links also occur. These structural distortions kink the DNA helix, triggering a cascade of cellular responses. The damage is recognized by repair mechanisms; however, if lesions exceed reparative capacity, signaling pathways such as p53-mediated apoptosis are activated, culminating in programmed cell death. Carboplatin’s unique leaving group confers greater kinetic stability than cisplatin, resulting in less premature reactivity in plasma and reduced off-target toxicity, while still ensuring sufficient intracellular activation for therapeutic effect. Physicochemical Properties and Stability Carboplatin is chemically defined as cis-diammine(1,1-cyclobutane-dicarboxylato)platinum(II), with the molecular formula C₆H ₁₂ N ₂ O ₄ Pt and a molecular weight of 371.25 g/mol. It presents as a white to off-white crystalline powder, odorless and stable under standard storage conditions. The compound exhibits high aqueous solubility (>10 mg/mL at 20°C), facilitating its formulation into ready-to-use solutions without the need for elaborate solubilizing agents. Its partition coefficient (log P) is notably low, reflecting hydrophilicity that influences distribution patterns. Carboplatin is non-hygroscopic and maintains integrity when protected from light and excessive heat, with a recommended shelf-life extending several years under proper containment. Crucially, it lacks the vesicant properties of some chemotherapeutics, minimizing risks associated with extravasation during venous access procedures. Pharmacokinetics and Metabolism Following intravenous delivery, Carboplatin displays linear pharmacokinetics with minimal plasma protein binding (approximately 24%), predominantly to albumin. It does not undergo hepatic metabolism; instead, it is eliminated renally via glomerular filtration in an unmetabolized form. The area under the concentration-time curve (AUC) serves as the principal determinant of both efficacy and myelosuppression, guiding dosing strategies such as Calvert’s formula (dose = target AUC × (GFR + 25)). Its terminal half-life ranges from 2.5 to 6 hours in patients with normal renal function, though it prolongs significantly in renal impairment, necessitating dose adjustments to mitigate cumulative toxicity. Safety Profile and Tolerability Considerations The adverse event landscape of Carboplatin is dominated by myelosuppression, specifically thrombocytopenia, neutropenia, and anemia, which are typically delayed in onset and cumulative across cycles. Nausea and vomiting are generally mild to moderate and readily controlled with modern antiemetics. Ototoxicity and neurotoxicity are markedly less frequent compared to cisplatin, preserving quality of life. Hypersensitivity reactions may emerge after multiple exposures, presenting as rash, bronchospasm, or hypotension, requiring premedication protocols. Vigilant monitoring of blood counts and renal parameters remains imperative throughout therapy. Formulation and Handling Standards Carboplatin is supplied as a sterile, preservative-free aqueous solution, typically at concentrations of 10 mg/mL in vials of varying volumes. It requires no reconstitution and can be directly administered or diluted further in compatible infusion fluids such as 5% dextrose or 0.9% sodium chloride. The solution is stable at room temperature for up to 8 hours post-preparation, though refrigeration extends this period. Healthcare personnel must employ standard cytotoxic handling precautions—gloves, gowns, and eye protection—to avert accidental exposure. Disposal follows institutional guidelines for hazardous pharmaceutical waste to prevent environmental contamination. Comparative Advantages in Therapeutic Index Relative to first-generation platinum agents, Carboplatin offers a superior therapeutic ratio. Its reduced nephrotoxic potential eliminates the need for aggressive hydration protocols, streamlining clinical workflows. The diminished incidence of severe nausea enhances patient comfort and reduces ancillary medication costs. Moreover, its predictable excretion kinetics allow for individualized dosing based on renal clearance, optimizing outcomes while curtailing unnecessary toxicity. These attributes have cemented its role in combination therapies alongside taxanes, etoposide, and gemcitabine, where synergistic effects amplify antitumor responses without prohibitive additive toxicities. Research Perspectives and Evolving Applications Ongoing investigations explore Carboplatin’s integration into novel therapeutic frameworks, including dose-dense schedules, neoadjuvant settings, and concurrent chemoradiotherapy. Pharmacogenomic studies aim to identify biomarkers predicting individual sensitivity and resistance, potentially enabling precision medicine approaches. Furthermore, research into nanoparticle encapsulation and targeted delivery systems seeks to augment tumor selectivity while sparing healthy tissues. Such advancements promise to expand Carboplatin’s clinical relevance well into the future. In summary, Carboplatin epitomizes a rationally designed antineoplastic agent that harmonizes potent cytotoxic activity with manageable tolerability. Its well-elucidated mechanisms, favorable physicochemical stability, and versatile clinical applications underscore its enduring significance in oncologic pharmacotherapy. Continuous refinement of its use, guided by pharmacokinetic modeling and emerging biomolecular insights, ensures that Carboplatin remains a cornerstone in the multimodal management of cancer.
Molecular Formula	C ₆ H ₁₂ N ₂ O ₄ Pt
Molecular Weight	371.25 g/mol
Appearance	White or almost white powder
Quality Standard	Enterprise standard; 98%- 102%(ICP-AES)
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0-28℃ for short term (days to weeks) or 8-20 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Double plastic bags inside, fiber drum outside, any quantity available.
Commercial package	Aluminium Tin, Fiber drum
Origin	China

Product Image

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FAQ

Q1. What is the Hyper chem payment term?
T/T advance
LC at sight
DP at sight
Trade assurance
Money gram

Q2. What is Hyper chem shipment policy?
Our policy is to strive for the quickest shipment time possible, with ready stock sample shipment typically going out the same day that your order was placed. Your satisfaction is very important to us.
For non-ready stock, please contact the Hyper Chem sales team to negotiate.

Q3. What hyper chem will provide after shipment?
For sample orders:
After shipment is done, an timely email including:

Track details (Fedex /TNT/DHL/EMS Track number)

Package photo

COA, MSDS, etc

Dispatch date & Estimated arriving time

Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided
in scan-copy and original, to help customers complete the customs clearance process.

Q4. What is Hyper Chem shipment term?

By Express
DHL  FedEx  TNT  EMS
Fast:5 days around
High cost, door to door service

By Air
Suitable for more than 50kg
Fast :3-7 days Hight cost, port to port, professional broker needed

By Sea
Suitable for more than 500kg
Slow:7-45 days, Low cost, port to port, professional broker needed
We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. Does hyper chem provide a shipment return policy?
Yes, we have.
Return Policy: At Hyper chem, your satisfaction is guaranteed. If you are dissatisfied for any reason with a product, please send back the unused portion along with your packing slip and a brief note on why you were dissatisfied within 45 days of purchase for a full refund to:

Q6. What is hyper chem After-sales service
•Documents support: COA ,MSDS, MOA ,MS Report,HNMR Report,SDS,DMF
• Customer Support: Shipment clearance support, quality issue support
• Automated Customer Service: Our worldwide customers enjoy immediate 24/7 access to the HYPER CHEM support team from any location, at any time.

Company profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.

Carboplatin (NSC 241240) is a DNA synthesis inhibitor which binds to DNA, inhibits replication and transcription and induces cell death. Carboplatin (NSC 241240) is a derivative of cisplatin and a potent anti-cancer agent.

Certificates

Basic Info

Product Name:

Carboplatin

Other Name:

PARAPLATIN;1,1-cyclobutanedicarboxylatediammineplatinum(ii);1-cyclobutanedicarboxylato(2-)-o,o’)-diammine((sp-4-2)-platinu;1-cyclobutanedicarboxylato)diammine-(cis-platinum(ii;DIAMMINE(1,1-CYCLOBUTANEDICARBOXYLATO)PLATINUM(II);CARBOPLATIN;CARBOPLATINUM;CIS-DIAMINE(1,1-CYCLOBUTANEDICARBOXYLATO)PLATINUM

CAS No.:

41575-94-4

Molecular Formula:

C6H12N2O4Pt

InChIKeys:

OLESAACUTLOWQZ-UHFFFAOYSA-L

Molecular Weight:

371.25

Exact Mass:

371.044495

EC Number:

255-446-0

NSC Number:

758182|241240|201345

DSSTox ID:

DTXSID3046742

Color/Form:

white

ATC Code:

L - Antineoplastic and immunomodulating agents

HScode:

28439000

Categories:

Antineoplastic Agents

Characteristics

PSA:

76.6

Appearance:

white crystal

Melting Point:

228-230°C

Flash Point:

189.6ºC

Water Solubility:

Soluble in water.

Storage Conditions:

Store at RT

Toxicity:

LD50 in mice (mg/kg): 150 i.p., 140 i.v.; in rats (mg/kg): 85 i.v. (Lelieveld)

Experimental Properties:

Incompatible with aluminum|Because of an interaction occurring between carboplatin & the metal aluminum, resulting in precipitate formation & loss of potency, only administration equipment such as needles, syringes, catheters, & sets that contain no aluminum should be used for this drug.

Critical Temperature & Pressure:

2-8°C

See More Carboplatin Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

Acute toxicity - Category 4, Dermal

Skin sensitization, Category 1

Acute toxicity - Category 4, Inhalation

Respiratory sensitization, Category 1

Germ cell mutagenicity, Category 1B

Reproductive toxicity, Category 1B

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H302+H312+H332 Harmful if swallowed, in contact with skin or if inhaled H317 May cause an allergic skin reaction H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled H340 May cause genetic defects H360 May damage fertility or the unborn child
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P271 Use only outdoors or in a well-ventilated area. P284 [In case of inadequate ventilation] wear respiratory protection. P203 Obtain, read and follow all safety instructions before use.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P317 Get medical help. P321 Specific treatment (see ... on this label). P362+P364 Take off contaminated clothing and wash it before reuse. P333+P317 If skin irritation or rash occurs: Get medical help. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P342+P316 If experiencing respiratory symptoms: Get emergency medical help immediately. P318 IF exposed or concerned, get medical advice.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Carboplatin Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Certifications:
Certification Report by Bureau Veritas

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

11 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	Carboplatin	5 KG	Mar 26, 2025
Netherlands	Carboplatin	5 KG	Aug 2, 2026
Pakistan	Carboplatin	15000 KG	Mar 30, 2026
India	CARBOPLATIN	1 KG	Jul 8, 2024
Brazil	Carboplatina	1.00 KG	Mar 28, 2025
United States	carboplatin	1 KG	Dec 16, 2024
India	carboplatin	1 KG	Nov 10, 2025
India	Carboplatin	100 KG	Nov 7, 2025
United States	Carboplatin	1.0 KG	Dec 14, 2024
United Arab Emirates	Carbopolatin	2.00 KG	Jul 23, 2024
Japan	Carboplatin	100 G	May 13, 2024

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99% Pure Carboplatin CAS 41575-94-4 High-Purity Antineoplastic Platinum Raw Material | USP/EP Anticancer API

Product Description

Seller Information

Inquiry History

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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