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Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > Dihexa for Sale > Bulk Price Dihexa Peptides 99% Pure for Mental Clarity CAS 1401708-83-5 Factory direct supply
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Bulk Price Dihexa Peptides 99% Pure for Mental Clarity CAS 1401708-83-5 Factory direct supply

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Unit Price:

$65-75/MT FOB

Get Latest Price
CAS No.:

1401708-83-5

Grade:

Pharmaceutical Grade

Content:

99%

Port:

GUANGZHOU

Brand:

LM

Packaging:

1g/10g/50g/100g

Price valid (until):

2027-02-01

Company Type:
Trader
Location:
China
Qualification:
Main Products:

Peptides

  • Product Description

  • Seller Information

  • Inquiry History

  • Description


      Product Detail  


    Pls input...

    Name :Julia

    Whatsapp/wechat:+86 17532387010

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    Regulation of Metabolism:

    MOTS-C helps regulate glucose metabolism and sensitivity, making it a key player in blood sugar regulation and potentially helpful in managing conditions like type 2 diabetes.


    Promotes Fat Loss:

    MOTS-C has been shown to enhance fat oxidation, which could support weight loss and prevent excessive fat accumulation, especially in the context of aging or metabolic disorders.


    Increases Energy Production:

    By boosting mitochondrial function, MOTS-C helps improve cellular energy production, potentially reducing fatigue and increasing overall vitality, particularly in aging individuals.


    Anti-Aging Properties:

    MOTS-C is thought to have anti-aging effects by improving metabolic health, protecting against oxidative stress, and enhancing the body's ability to handle the stress associated with aging.


    Improves Exercise Performance:

    Some studies suggest that MOTS-C can enhance physical performance and endurance by increasing the efficiency of energy use within cells, potentially improving athletic performance and recovery.


    Supports Muscle Health:

    MOTS-C may play a role in maintaining muscle mass and improving muscle function, particularly in older adults, by modulating mitochondrial function and muscle metabolism.

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    Dihexa More Info

    Dihexa is a synthetic peptide derived from angiotensin IV, designed primarily for neuropharmacological applications. It exhibits significant potential in treating neurodegenerative disorders such as Alzheimer's disease and cognitive impairments.

    Mechanism of Action

    Dihexa functions by mimicking and enhancing the effects of nerve growth factor (NGF), crucial for neuronal survival and function. It binds with high affinity to hepatocyte growth factor (HGF) and its receptor, c-Met, activating pathways that promote neural growth and repair. This interaction leads to increased synaptic plasticity and density, particularly in the hippocampus, which is vital for memory and learning processes . Dihexa's ability to cross the blood-brain barrier allows it to exert its effects directly within the central nervous system, a significant advantage over many therapeutic agents.

    Applications

    The primary applications of Dihexa include:
    1. Cognitive Enhancement: Animal studies have shown that Dihexa can improve cognitive function and memory recovery in models simulating Alzheimer's disease.
    2. Neuroprotection: It has demonstrated protective effects against neuronal apoptosis, suggesting potential use in various neurodegenerative diseases.
    3. Synaptogenesis: Dihexa promotes the formation of new synapses, which is critical for restoring cognitive functions impaired by disease or injury.

    Routes of Administration

    Dihexa can be administered orally, which is notable for a peptide drug. Its formulation allows it to maintain metabolic stability and a prolonged half-life of approximately 12.68 days, enhancing its potential therapeutic efficacy

    Safety and Side Effects

    Initial safety studies indicate that Dihexa exhibits no apparent toxicity or neoplastic induction, even though c-Met is recognized as an oncogene. However, comprehensive human trials are still necessary to fully ascertain its safety profile . As a research compound, it is primarily intended for laboratory use, and its long-term effects in humans remain unstudied.

    • Items Specifications
      Product Name   Dihexa
      CAS number  1401708-83-5
      Purity  99%
      Molecular Weight  504.66
      Appearance  White powder
      Molecular Formula  C27H44N4O5
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    • Peptide Storage Guidelines: General Tips

      When storing peptides, remember to:
      • Store peptide in a cold, dry, dark place
      • Avoid repeated freezing and thawing of peptide
      • Avoid overexposure to the air
      • Avoid light exposure
      • Avoid storing peptides in solution long term
      • Aliquot peptide according to experimental requirements


    • Product Specification:                                                   


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      Company Profile                                                            

        Changsha Duole Technology Co., Ltd was established in 2020 with strong research and development capabilities and superb synthesis technology, as well as advanced quality control measures.

        With synthetic biology platform technology as the core, it conducts innovative research and development, mainly engaged in the research and development of recombinantly expressed pharmaceutical peptides and proteins. Its products include innovative drugs, APIs, pharmaceutical and green synthetic industrial enzymes, functional peptides and protein products, etc.

        Its core team is composed of technical experts in the fields of pharmaceutical engineering, fermentation engineering and protein engineering. The company has built a 3,300-square-meter recombinant drug research and development center in Shibei, Yuelu District, Changsha City. It has a complete pharmaceutical engineering, preparation and quality research system and talent team, and has built a GMP workshop to meet the international market API supply and CDMO services.

        At present, our company has realized the industrialization of a variety of biosynthetic peptide products and has obtained cooperation orders from many well-known domestic and foreign pharmaceutical companies.Shop Bulk Price Dihexa Peptides 99% Pure for Mental Clarity CAS 1401708-83-5 Factory direct supply-Detailed Image 10

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      Why Choose us                                                             

    Our company has independent factories, mass production of pharmaceutical intermediates, organic intermediates and other raw materials, widely used in medicine, health care products, cosmetics, nutritional supplements, food additives and other fields.

        Our company adheres to the business philosophy of integrity and cooperation. scientific innovation and service first.With absolute quality assurance as the purpose and perfect service system as the basis, our company provides efficient and satisfactory consulting services, sincerely welcomes your business inquiries,and looks forward to working with you to create a new future.  

    Key Products:
    Our primary focus encompasses a range of products, including weight loss peptides, medicinal peptides, cosmetic peptides, and customized peptides. Notable among our weight loss peptide offerings are Semaglutide, Tirzepatide, Retatrutide, and others.



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    Items Specifications






    Certificates
    • Bulk Price Dihexa Peptides 99% Pure for Mental Clarity CAS 1401708-83-5 Factory direct supply Certificates 1 TDS

    Basic Info
    Product Name:

    Dihexa

    Other Name:

    L-Isoleucinamide,N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-;N-(1-Oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-L-isoleucinamide;Dihexa;N-Hexanoic-Tyr-Ile-(6)aminohexanoic amide

    CAS No.:

    1401708-83-5

    Molecular Formula:

    C27H44N4O5

    InChIKeys:

    InChIKey=XEUVNVNAVKZSPT-JTJYXVOQSA-N

    Molecular Weight:

    504.7

    Exact Mass:

    504.66

    Characteristics
    Density:

    1.111±0.06 g/cm3(Predicted)

    Boiling Point:

    866.2±65.0 °C(Predicted)

    Research
    Class:

    Angiotensin IV-derived oligopeptide / HGF-c-Met potentiator

    Status:

    Research compound — Not FDA approved

    Mechanism:

    A synthetic, orally active, blood-brain-barrier-permeable oligopeptide (Hexanoyl-Tyr-Ile-Ahx-NH₂) derived from angiotensin IV. Dihexa binds hepatocyte growth factor (HGF) with high affinity (Kd = 65 pM) and allosterically potentiates HGF activity at its receptor c-Met, promoting dendritic spinogenesis and synaptogenesis. In preclinical models it was reported to be seven orders of magnitude more potent than BDNF at promoting synapse formation. Note: the foundational 2014 paper (McCoy AT, et al. Neurobiol Learn Mem. 2014) was retracted in 2025.

    EC50 (HGF Binding KD):

    65 pM

    Activity note:

    Dihexa is an HGF potentiator, not a direct receptor agonist. It does not activate c-Met alone but markedly augments HGF-induced c-Met activation at low nanomolar HGF concentrations. Functional synaptogenic activity was reported at 10⁻¹°–10⁻⁻ M (original data now subject to retraction).

    Source:

    Original report: McCoy AT, et al. Neurobiol Learn Mem. 2014;115:112-120 (retracted 2025). Benoist CC, et al. J Pharmacol Exp Ther. 2014;351(3):628-637.

    Clinical Development:

    NCT04488419

    References
    PubChem:

    PubChem

    UNII:

    9WYX65A5C2

    Disclaimer:

    Dihexa is NOT FDA-approved or EMA-approved as a medicine. It is a research compound only. The foundational 2014 paper describing its synaptogenic potency was retracted in 2025. Its phosphate prodrug fosgonimeton failed a Phase 2/3 Alzheimer’s trial (LIFT-AD, 2024). This listing is for industrial and laboratory research use only. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    Peptides

    Location:

    Jinxing Middle Road, Xihu Street, Yuelu District, Changsha City, Hunan Province

    Payment Terms:

    TT against copy of documents,D/P,L/C,100% TT in advance

    Average lead Time:

    1

    Total Annual Revenue:

    Less than $1 million

    Total Employees:

    11-50

    Year of Establishment:

    2023

    Certifications:

    COA

    Company Profile
       Our company is a modern advanced enterprise specializing in production and exportation of APIs, Pharmaceutical intermediates, plant extracts etc. Our products are widely used in medicine, health care products, cosmetics, nutritional supplements and food additives areas. Our factory covers an area of 95 acres, the proposed construction of the plant will be GMP standards, the factory environment clean and tidy, rational layout, with large and medium-sized production workshop and repocessed shop. It is equipped with advanced equipment quality inspection and research center. Those products of both quality and technical content have reached the domestic advanced level. Since its establishment, the company has attached great importance to the team training and technical reform. Our modern production equipment guarantees for a fast and effective production with a superior degree of accuracy throughout the whole production line, everything is done in-house, processing, extraction, packaging and transportation of all links, ensuring maximum quality and efficiency. We are constantly research and development new ingredients and innovative new products, have earned the respect & Admiration from the worldwide customers. After years of continuous development, company has been accumulated rich experience in international trade and customer resources, established a stable customer base and perfect marketing service network. In addition, the company has established long-term technical cooperation with experts and professors from many universities and research institutes in the province.

  • Inquiry History
    162 Inquiries
    Country Product Purchase Quantity Date Posted
    Canada

    Dihexa 1401708-83-5

    1 G Mar 8, 2026
    Bulgaria

    Customized peptides high purity Dihexa with fast shipping door to door CAS 1401708-83-5

    10 G May 27, 2025
    United States

    Dihexa

    25 G Jan 26, 2025
    Russia

    DIHEXA

    50.00 G Aug 14, 2024
    Canada

    Dihexa

    130  Aug 12, 2026
    Brazil

    dihexa

    90 MG Aug 4, 2026
    United States

    Dihexa raw powder

    10 G Jul 26, 2026
    Singapore

    Dihexa

    10 PCS Jul 15, 2026
    United States

    Dihexa

    1 G Jul 11, 2026
    Sweden

    Dihexa

    10 PCS Jul 8, 2026
    Australia

    Dihexa

    1 MT Jul 2, 2026
    United States

    Dihexa

    10 G Jun 14, 2026
    Germany

    Dihexa

    1 G May 25, 2026
    Thailand

    Dihexa

    1 G May 12, 2026
    United States

    Dihexa

    100 G May 4, 2026
    Italy

    simona migliori

    10 MT Apr 23, 2026
    United States

    Dihexa

    10 G Apr 22, 2026
    United States

    Dihexa

    1 G Apr 22, 2026
    Ecuador

    DIHEXA

    10 PCS Apr 19, 2026
    United States

    dihexa

    10 MG Apr 13, 2026
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