Bulk Price Dihexa Peptides 99% Pure for Mental Clarity CAS 1401708-83-5 Factory direct supply
TDS 162 Inquiries
1401708-83-5
Pharmaceutical Grade
99%
GUANGZHOU
LM
1g/10g/50g/100g
2027-02-01
Peptides
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Product Description
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Seller Information
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Inquiry History
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DescriptionCertificates
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TDS
Basic Info-
Product Name:
Dihexa
Other Name:L-Isoleucinamide,N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-;N-(1-Oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-L-isoleucinamide;Dihexa;N-Hexanoic-Tyr-Ile-(6)aminohexanoic amide
CAS No.:1401708-83-5
Molecular Formula:C27H44N4O5
InChIKeys:InChIKey=XEUVNVNAVKZSPT-JTJYXVOQSA-N
Molecular Weight:504.7
Exact Mass:504.66
Categories:
Characteristics-
Density:
1.111±0.06 g/cm3(Predicted)
Boiling Point:866.2±65.0 °C(Predicted)
Research-
Class:
Angiotensin IV-derived oligopeptide / HGF-c-Met potentiator
Status:Research compound — Not FDA approved
Mechanism:A synthetic, orally active, blood-brain-barrier-permeable oligopeptide (Hexanoyl-Tyr-Ile-Ahx-NH₂) derived from angiotensin IV. Dihexa binds hepatocyte growth factor (HGF) with high affinity (Kd = 65 pM) and allosterically potentiates HGF activity at its receptor c-Met, promoting dendritic spinogenesis and synaptogenesis. In preclinical models it was reported to be seven orders of magnitude more potent than BDNF at promoting synapse formation. Note: the foundational 2014 paper (McCoy AT, et al. Neurobiol Learn Mem. 2014) was retracted in 2025.
EC50 (HGF Binding KD):65 pM
Activity note:Dihexa is an HGF potentiator, not a direct receptor agonist. It does not activate c-Met alone but markedly augments HGF-induced c-Met activation at low nanomolar HGF concentrations. Functional synaptogenic activity was reported at 10⁻¹°–10⁻⁻ M (original data now subject to retraction).
Source:Original report: McCoy AT, et al. Neurobiol Learn Mem. 2014;115:112-120 (retracted 2025). Benoist CC, et al. J Pharmacol Exp Ther. 2014;351(3):628-637.
Clinical Development:
References-
PubChem:UNII:Literature:
Benoist CC, et al. J Pharmacol Exp Ther. 2014 — HGF/c-Met mechanism; McCoy AT, et al. Neurobiol Learn Mem. 2014 — Synaptogenesis data (Retracted 2025); Athira Pharma: Fosgonimeton (prodrug) pipeline status
Disclaimer:Dihexa is NOT FDA-approved or EMA-approved as a medicine. It is a research compound only. The foundational 2014 paper describing its synaptogenic potency was retracted in 2025. Its phosphate prodrug fosgonimeton failed a Phase 2/3 Alzheimer’s trial (LIFT-AD, 2024). This listing is for industrial and laboratory research use only. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.
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Seller Information
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Business Type:
Trader
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Main Products:
Peptides
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Location:
Jinxing Middle Road, Xihu Street, Yuelu District, Changsha City, Hunan Province
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Payment Terms:
TT against copy of documents,D/P,L/C,100% TT in advance
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Average lead Time:
1
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Total Annual Revenue:
Less than $1 million
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Total Employees:
11-50
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Year of Establishment:
2023
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Certifications:
COA
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Inquiry History162 Inquiries
Country Product Purchase Quantity Date Posted
Canada
Dihexa 1401708-83-5
1 G Mar 8, 2026
Bulgaria
Customized peptides high purity Dihexa with fast shipping door to door CAS 1401708-83-5
10 G May 27, 2025
United States
Dihexa
25 G Jan 26, 2025
Russia
DIHEXA
50.00 G Aug 14, 2024
Canada
Dihexa
130 Aug 12, 2026
Brazil
dihexa
90 MG Aug 4, 2026
United States
Dihexa raw powder
10 G Jul 26, 2026
Singapore
Dihexa
10 PCS Jul 15, 2026
United States
Dihexa
1 G Jul 11, 2026
Sweden
Dihexa
10 PCS Jul 8, 2026
Australia
Dihexa
1 MT Jul 2, 2026
United States
Dihexa
10 G Jun 14, 2026
Germany
Dihexa
1 G May 25, 2026
Thailand
Dihexa
1 G May 12, 2026
United States
Dihexa
100 G May 4, 2026
Italy
simona migliori
10 MT Apr 23, 2026
United States
Dihexa
10 G Apr 22, 2026
United States
Dihexa
1 G Apr 22, 2026
Ecuador
DIHEXA
10 PCS Apr 19, 2026
United States
dihexa
10 MG Apr 13, 2026 Post an enquiry for this product