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Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > Larotrectinib Sulfate for Sale > Larotrectinib Sulfate CAS 1223405-08-0 Selective TRK Kinase Inhibitor for NTRK Fusion-Positive Cancer Research hfd
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Larotrectinib Sulfate CAS 1223405-08-0 Selective TRK Kinase Inhibitor for NTRK Fusion-Positive Cancer Research hfd

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Unit Price:

$100-130/G FOB

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CAS No.:

1223405-08-0

Grade:

Reagent Grade

Content:

99%

Port:

qingdao

Brand:

//

Packaging:

5g, 25g, 100g, 500g

Price valid (until):

2026-09-27

Company Type:
Trader
Location:
China
Qualification:
Main Products:

Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

  • Product Description

  • Seller Information

  • Description

    —— Product Specification ——

    Parameter Specification Details
    Product Name Larotrectinib Sulfate LOXO-101 Sulfate; ARRY-470 Sulfate; Vitrakvi 
    CAS Number 1223405-08-0 1223405-08-0 
    Molecular Formula C₂₁H₂₄F₂N₆O₆S C21H22F2N6O2·H2SO4 
    Molecular Weight 526.51 g/mol — 
    Appearance Light yellow to brown solid powder — 
    Purity ≥98.0% Determined by HPLC 
    Solubility DMSO: ≥18.47 mg/mL; Ethanol: ≥2.14 mg/mL; Water: ≥29.65 mg/mL
    Storage -20°C; powder stable for 2-3 years; in solvent at -80°C (6 months) or -20°C (1 month) Sealed containers, protect from moisture 
    Packaging 5mg, 10mg, 25mg, 50mg, 100mg, 500mg, 1g Amber glass vials
    Application Research use only Oncology research, kinase inhibition studies


    —— Product Detail ——

    Product Overview

    • Larotrectinib Sulfate (CAS 1223405-08-0), also known as LOXO-101 Sulfate and marketed under the brand name Vitrakvi, is a potent, selective, ATP-competitive inhibitor of the tropomyosin receptor kinase (TRK) family, which includes TRKA, TRKB, and TRKC . It appears as a light yellow to brown solid powder with the molecular formula C₂₁H₂₄F₂N₆O₆S and a molecular weight of 526.51 g/mol


    Packaging & Shipping

                  • Research quantities: 5mg, 10mg, 25mg amber glass vials

                  • Bulk quantities: 50mg, 100mg amber glass bottles

                  • Custom packaging available upon request

                  • Not classified as hazardous material for transport under normal conditions

                  • Product for research and analytical use only; not for human therapeutic use

    Shop CAS 18048-64-1 Eltrombopag Intermediate for Pharmaceutical Research  kr-Detailed Image 1

    Company profile ——


     Shop CAS 1231930-42-9 Abemaciclib Intermediate for Pharma researech use KR-Detailed Image 1

    Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

    Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

    We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

    To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

    Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

     

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    —— Q&A ——

    Q1: How to confirm the product quality before placing orders?
    A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

    Q2: Can you supply free samples?
    A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

    Q3: How do you treat quality complaints?
    A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

    Q4: What is your MOQ? Is there a discount?
    A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
    Q: Is there a discount?
    A: Yes, for larger quantities, we always support with better prices.

    Q5: How to start orders or make payments?
    A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.



    ECHEMI Editorial Reference
    Larotrectinib (LOXO-101) sulfate is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C).
    Larotrectinib Sulfate is the sulfate salt form of larotrectinib, an orally available, tropomyosin receptor kinase (Trk) inhibitor, with potential antineoplastic activity. Upon administration, larotrectinib binds to Trk, thereby preventing neurotrophin-Trk interaction and Trk activation, which results in both the induction of cellular apoptosis and the inhibition of cell growth in tumors that overexpress Trk. Trk, a receptor tyrosine kinase activated by neurotrophins, is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival.

    Certificates
    • Larotrectinib Sulfate CAS 1223405-08-0 Selective TRK Kinase Inhibitor for NTRK Fusion-Positive Cancer Research hfd Certificates 1 TDS

    Basic Info
    Product Name:

    Larotrectinib Sulfate

    Other Name:

    LOXO-101 (sulfate);Larotrectinib/LOXO 101/ARRY 470 sulfate;ARRY 470) sulfate;Larotrectinib sulfate;Larotrectinib(LOXO 101;Larotrectinib (LOXO-101) sulfate;1-Pyrrolidinecarboxamide, N-[5-[(2R)-2-(2,5-difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-, (3S)-, sulfate (1:1);ARRY-470, Larotrectinib

    CAS No.:

    1223405-08-0

    Molecular Formula:

    C21H24F2N6O6S

    InChIKeys:

    PXHANKVTFWSDSG-RZOMTXEQNA-N

    Molecular Weight:

    526.52

    Exact Mass:

    526.144592

    EC Number:

    232-655-5

    UNII:

    RDF76R62ID

    NCI Thesaurus Code:

    C156895

    Color/Form:

    Light yellow to brown

    ATC Code:

    L01XE53

    Characteristics
    PSA:

    168.98000

    XLogP3:

    3.45140

    Critical Temperature & Pressure:

    Store at -20°C

    Hazard Identification

    Classification of the substance or mixture

    no data available

    GHS label elements, including precautionary statements

    Pictogram(s) no data available
    Signal word

    no data available

    Hazard statement(s)

    no data available

    Precautionary statement(s)
    Prevention

    no data available

    Response

    no data available

    Storage

    no data available

    Disposal

    no data available

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

    Location:

    RONGSHENG BEIYUANDAJIE 9, LICHENG DISTRICT,JINAN, SHANDONG CHINA

    Payment Terms:

    TT against copy of documents,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    7

    Total Annual Revenue:

    $1 million-$2.5 million

    Total Employees:

    11-50

    Year of Establishment:

    2022

    Jinan Topfull Chemical Co., Ltd. is a global chemical Industrial and focuses on advanced chemical technology. Specialized in Cosmetic materials, water treatment, fine chemicals and so on. We are looking forward to working together with the people of all circles at home and abroad to seek common development!
  • Country Product Purchase Quantity Date Posted
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