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Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > Lapatinib for Sale > Lapatinib CAS 231277-92-2 Dual EGFR/HER2 Tyrosine Kinase Inhibitor for Breast Cancer Research hfd
Lapatinib CAS 231277-92-2 Dual EGFR/HER2 Tyrosine Kinase Inhibitor for Breast Cancer Research hfd buy - large image1
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Lapatinib CAS 231277-92-2 Dual EGFR/HER2 Tyrosine Kinase Inhibitor for Breast Cancer Research hfd

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Unit Price:

$100-130/G FOB

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CAS No.:

231277-92-2

Grade:

Reagent Grade

Content:

99%

Port:

qingdao

Brand:

//

Packaging:

5g, 25g, 100g, 500g

Price valid (until):

2026-09-27

Company Type:
Trader
Location:
China
Qualification:
Main Products:

Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

  • Product Description

  • Seller Information

  • Description

    —— Product Specification ——

    Parameter Specification Details
    Product Name Lapatinib GW572016; Tykerb
    CAS Number 231277-92-2 231277-92-2
    Molecular Formula C₂₉H₂₆ClFN₄O₄S
    Molecular Weight 581.06 g/mol
    Appearance Solid powder Visual inspection
    Purity ≥98.0% Determined by HPLC 
    Melting Point 136 – 140°C
    Solubility DMSO: soluble
    Storage -20°C for long-term Sealed containers, protect from moisture and light
    Packaging 100mg, 500mg, 1g, 5g, 25g Amber glass vials
    Application Research use only Oncology research, kinase inhibition studies


    —— Product Detail ——

    Product Overview

    • Lapatinib (CAS 231277-92-2), also known as GW572016 and marketed under the brand name Tykerb, is an orally active, reversible dual tyrosine kinase inhibitor that interrupts both the HER2/neu (ErbB-2) and epidermal growth factor receptor (EGFR) pathways . It appears as a solid powder with the molecular formula C₂₉H₂₆ClFN₄O₄S and a molecular weight of 581.06 g/mol


    Packaging & Shipping

                  • Research quantities: 5mg, 10mg, 25mg amber glass vials

                  • Bulk quantities: 50mg, 100mg amber glass bottles

                  • Custom packaging available upon request

                  • Not classified as hazardous material for transport under normal conditions

                  • Product for research and analytical use only; not for human therapeutic use

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    Company profile ——


     Shop CAS 1231930-42-9 Abemaciclib Intermediate for Pharma researech use KR-Detailed Image 1

    Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

    Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

    We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

    To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

    Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

     

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    —— Q&A ——

    Q1: How to confirm the product quality before placing orders?
    A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

    Q2: Can you supply free samples?
    A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

    Q3: How do you treat quality complaints?
    A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

    Q4: What is your MOQ? Is there a discount?
    A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
    Q: Is there a discount?
    A: Yes, for larger quantities, we always support with better prices.

    Q5: How to start orders or make payments?
    A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.



    ECHEMI Editorial Reference
    Lapatinib (GW572016) is a potent EGFR and ErbB2 inhibitor with IC50s of 10.2 and 9.8 nM, respectively.
    Solid
    Lapatinib is an organofluorine compound, an organochlorine compound, a member of quinazolines and a member of furans. It has a role as an antineoplastic agent and a tyrosine kinase inhibitor. It derives from a monofluorobenzene.|Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug Capecitabine. Lapatinib is human epidermal growth factor receptor type 2 (HER2/ERBB2) and epidermal growth factor receptor (HER1/EGFR/ERBB1) tyrosine kinases inhibitor. It binds to the intracellular phosphorylation domain to prevent receptor autophosphorylation upon ligand binding.|Lapatinib is a Kinase Inhibitor. The mechanism of action of lapatinib is as a Protein Kinase Inhibitor.|Lapatinib is a small molecule inhibitor of several tyrosine kinase receptors involved in tumor cell growth that is used in the therapy of advanced breast cancer and other solid tumors. Lapatinib therapy is associated with transient elevations in serum aminotransferase levels and rare instances of clinically apparent acute liver injury.|Lapatinib is a synthetic, orally-active quinazoline with potential antineoplastic properties. Lapatinib reversibly blocks phosphorylation of the epidermal growth factor receptor (EGFR), ErbB2, and the Erk-1 and-2 and AKT kinases; it also inhibits cyclin D protein levels in human tumor cell lines and xenografts. EGFR and ErbB2 have been implicated in the growth of various tumor types.|A quinazoline derivative that inhibits EPIDERMAL GROWTH FACTOR RECEPTOR and HER2 (RECEPTOR, ERBB-2) tyrosine kinases. It is used for the treatment of advanced or metastatic breast cancer, where tumors overexpress HER2.

    Certificates
    • Lapatinib CAS 231277-92-2 Dual EGFR/HER2 Tyrosine Kinase Inhibitor for Breast Cancer Research hfd Certificates 1 TDS

    Basic Info
    Product Name:

    Lapatinib

    Other Name:

    4-Quinazolinamine,N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-;N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine;GW 572016;Lapatinib;4-[[3-Chloro-4-(3-fluorobenzyloxy)phenyl]amino]-6-[5-[[(2-methanesulfonylethyl)amino]methyl]furan-2-yl]quinazoline;GSK 572016;N-[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furyl]-4-quinazolinamine;GW 572016X;N-[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl]-6-[5-[[[2-(methanesulfonyl)ethyl]amino]methyl]-2-furyl]-4-quinazolinamine;Tyverb;N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine;N-[4-(3-Fluorobenzyloxy)-3-chlorophenyl]-6-[5-[[2-(methylsulfonyl)ethylamino]methyl]furan-2-yl]quinazolin-4-amine;GD 2016;Tycerb

    CAS No.:

    231277-92-2

    Molecular Formula:

    C29H26ClFN4O4S

    InChIKeys:

    InChIKey=BCFGMOOMADDAQU-UHFFFAOYSA-N

    Molecular Weight:

    581.0575432

    Exact Mass:

    581.06

    EC Number:

    1806241-263-5

    UNII:

    0VUA21238F

    NSC Number:

    745750

    DSSTox ID:

    DTXSID7046675

    NCI Thesaurus Code:

    C26653

    ATC Code:

    L01XE07|L - Antineoplastic and immunomodulating agents

    HScode:

    2934999090

    Characteristics
    PSA:

    115

    XLogP3:

    5.1

    Appearance:

    Solid

    Density:

    1.4±0.1 g/cm3

    Boiling Point:

    750.7°C at 760 mmHg

    Flash Point:

    407.8±32.9 °C

    Refractive Index:

    1.645

    Water Solubility:

    2.23e-02 g/L

    Storage Conditions:

    Store at 25 deg C (77 deg F); excursions permitted to 15 deg to 30 deg C (59 deg to 86 deg F).

    Vapor Pressure:

    1.63X10-17 mm Hg at 25 deg C (est)

    Henrys Law Constant:

    Henry's Law constant = 4.93X10-22 atm-cu m/mol at 25 °C (est)

    Dissociation Constants:

    pKa1 = 3.80 (amine); pKa2 = 7.20 (amine)

    Experimental Properties:

    Hydroxyl radical reaction rate constant = 3.04X10-10 cu cm/molec-sec at 25 °C (est)

    Hazard Identification

    Classification of the substance or mixture

    no data available

    GHS label elements, including precautionary statements

    Pictogram(s) no data available
    Signal word

    no data available

    Hazard statement(s)

    no data available

    Precautionary statement(s)
    Prevention

    no data available

    Response

    no data available

    Storage

    no data available

    Disposal

    no data available

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

    Location:

    RONGSHENG BEIYUANDAJIE 9, LICHENG DISTRICT,JINAN, SHANDONG CHINA

    Payment Terms:

    TT against copy of documents,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    7

    Total Annual Revenue:

    $1 million-$2.5 million

    Total Employees:

    11-50

    Year of Establishment:

    2022

    Jinan Topfull Chemical Co., Ltd. is a global chemical Industrial and focuses on advanced chemical technology. Specialized in Cosmetic materials, water treatment, fine chemicals and so on. We are looking forward to working together with the people of all circles at home and abroad to seek common development!
  • Country Product Purchase Quantity Date Posted
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