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Sevelamer carbonate 845273-93-0

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Unit Price:

$9-10/G FOB

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CAS No.:

845273-93-0

Grade:

Pharmaceutical Grade

Content:

99.99%

Port:

shanghai

Brand:

Orient

Packaging:

Vial/Bottle/Bag/Carton

Price valid (until):

2026-10-01

Company Type:
Trader
Location:
China
Qualification:
Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

  • Product Description

  • Seller Information

  • Inquiry History

  • Description



    Sevelamer Carbonate

    Properties

    Storage Condition: Room Temperature, under inert atmosphere

    Solubility: <4.74 mg/mL, soluble in DMSO

    Form: Solid

    Color: White to light brown

    Main Application: Small‑molecule pharmaceutical intermediate
    InChI: InChI=1S/C3H5ClO.C3H7N.CH2O3/c4-1-3-2-5-3;1-2-3-4;2-1(3)4/h3H,1-2H2;2H,1,3-4H2;(H2,2,3,4)

    InChIKey: PADGNZFOVSZIKZ-UHFFFAOYSA‑N

    SMILES: C(O)(O)=O.C(C1OC1)Cl.C(=C)CN

    Uses & Synthesis Background

    Biological Activity

    Sevelamer carbonate is a non‑absorbable cross‑linked polymer phosphate‑binding agent. It features a polymeric backbone similar to sevelamer hydrochloride, with carbonate replacing chloride as the counter‑ion.

    In‑vitro Research

    Sevelamer carbonate is developed as an alternative to sevelamer hydrochloride with enhanced buffering capacity. Its molecular framework contains carbon chains linked with multiple amine groups, with each amine moiety separated from the main backbone by one carbon atom.

    Under intestinal‑simulated conditions, sevelamer carbonate becomes protonated and binds phosphorus species via ionic and hydrogen‑bond interactions. Such interactions reduce available phosphorus content within simulated gastrointestinal environment, lowering phosphorus uptake. Besides phosphorus‑binding properties, its polyamine‑rich polymeric structure can bind bile acids, which may contribute to total cholesterol reduction.

    In‑vivo Research

    From experimental chronic kidney disease animal model studies, sevelamer carbonate shows effects against inflammation and endotoxaemia induced by renal failure. In high‑phosphorus diet rat models, sevelamer carbonate exhibits beneficial impacts on renal function disorder, secondary hyperparathyroidism and vascular calcification.
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    ECHEMI Editorial Reference
    A polymeric amine that binds phosphate and is used to treat HYPERPHOSPHATEMIA in patients with kidney disease.
    Sevelamer carbonate (SC) is a non-absorbed phosphate binding crosslinked polymer, with the same polymeric structure as sevelamer hydrochloride, in which carbonate replaces chloride as the counterion. SC has been found to have the same safety and efficacy profile as Sevelamer HCl in HD patients.Sevelamer carbonate(Renvela) is a nonaluminum, non-calcium-basedphosphorus binder that traps phosphorus in the bowel through ion exchange and hydrogen binding. This drug replaced sevelamer hydrochloride(Renagel) and has an advantage of not generating an acid load, as its precursor, sevelamer hydrochloride, did. It also has the advantage of lowering LDL cholesterol due to gut binding of bile acids.

    Certificates

    Basic Info
    Product Name:

    Sevelamer carbonate

    Other Name:

    2-Propen-1-amine polymer with (chloromethyl)oxirane carbonate;Sevelamer carbonate;Carbonic acid, compd. with 2-(chloromethyl)oxirane polymer with 2-propen-1-amine;Sevelam;2-Propen-1-amine polymer with (chloromethyl)oxiran;2-Propen-1-aminepolymerwith;carbonic acid,2-(chloromethyl)oxirane,prop-2-en-1-amine;SIM862 Sevelamer Carbonate-----25gm

    CAS No.:

    845273-93-0

    Molecular Formula:

    C7H14ClNO4

    InChIKeys:

    PADGNZFOVSZIKZ-UHFFFAOYSA-N

    Molecular Weight:

    211.64

    Exact Mass:

    211.0611356

    EC Number:

    682-521-9

    Color/Form:

    White to Pale Beige

    ATC Code:

    V03AE02

    Characteristics
    Critical Temperature & Pressure:

    Room Temperature, under inert atmosphere

    Hazard Identification

    Classification of the substance or mixture

    Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 3

    GHS label elements, including precautionary statements

    Pictogram(s) No symbol.
    Signal word

    No signal word

    Hazard statement(s)

    H412 Harmful to aquatic life with long lasting effects

    Precautionary statement(s)
    Prevention

    P273 Avoid release to the environment.

    Response

    none

    Storage

    none

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    pharmaceutical intermediates,peptides,electronic chemicals

    Location:

    Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

    Payment Terms:

    100% TT in advance

    Average lead Time:

    10

    Total Annual Revenue:

    $10 million-$25 million

    Total Employees:

    51-100

    Year of Establishment:

    2024

    A reliable supplier is like insurance.

    We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals,food additives, and other fine chemical products.
    Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

    Website: orientchem.cc
    Email: scarlett@orientchem.cc
    WhatsApp: +86 17753254221

  • Inquiry History
    3 Inquiries
    Country Product Purchase Quantity Date Posted
    Romania

    Sevelamer carbonate

    1000 G Aug 31, 2026
    Costa Rica

    Sevelamer Carbonate

    600 G Jul 18, 2026
    Lithuania

    Sevelamer Carbonate

    250 G Jul 4, 2026
    Post an enquiry for this product
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