Psoralen 98% Purity CAS 66-97-7 Furanocoumarin for Photoreactive and Anticancer Research Reagent Grade

• • • • • • • • • • • • Product Overview

                        Psoralen, also known as psoralene or furocoumarin, is a naturally occurring furanocoumarin compound found in various plants including Psoralea corylifolia , Ficus carica (fig), and Apium graveolens (celery) . It is a linear furanocoumarin formed by the fusion of a furan ring with a coumarin nucleus . This product is a high-purity research-grade reagent with a purity of ≥98% as determined by HPLC analysis, appearing as a white to off-white crystalline powder . It is primarily used in photoreactive research, anticancer research, and natural product chemistry.

                        Chemical Properties

                        • Molecular Formula: C₁₁H₆O₃

                        • Molecular Weight: 186.16 g/mol

                        • Synonyms: Psoralene; Furocoumarin; 7H-Furo[3,2-g]chromen-7-one

                        • Melting Point: 160-162°C

                        • Boiling Point: 362.6±37.0 °C (Predicted)

                        • Density: 1.4±0.1 g/cm³ (Predicted)

                        • Flash Point: 173.1±26.5 °C

                        • LogP: 2.08

                        • Solubility: Soluble in DMSO, methanol, ethanol; slightly soluble in water

                        Natural Source

                        Psoralen is found in various plant species including Psoralea corylifolia , Ficus carica (fig), Apium graveolens (celery), and Ammi majus. It is a major bioactive component of these plants.

                        Biological Activity

                        • Photoreactive Activity: Psoralen is a well-known photosensitizing agent. Upon exposure to UVA radiation, it intercalates into DNA and forms covalent cross-links with pyrimidine bases, inhibiting DNA replication and transcription . This property underlies its use in PUVA therapy (psoralen plus UVA) for skin conditions such as psoriasis and vitiligo .

                        • Anticancer Activity: Studies have demonstrated that psoralen exhibits antiproliferative and cytotoxic effects against various cancer cell lines, including breast cancer, leukemia, and melanoma .

                        • Antimicrobial Activity: Exhibits activity against certain bacterial and fungal strains .

                        • Antioxidant Activity: As a phenolic compound, it shows free radical scavenging activity .

                        • Osteogenic Activity: Research suggests that psoralen may promote osteoblast proliferation and differentiation, making it valuable for bone-related research .

                        Quality Specifications

                        • Purity: ≥98.0% (determined by HPLC area normalization)

                        • Appearance: White to off-white crystalline powder

                        • Identification: Conforms to structure by NMR and Mass Spectrometry

                        • Loss on Drying: ≤0.5%

                        • Residue on Ignition: ≤0.1%

                        • Heavy Metals: ≤10 ppm

                        • Each batch is accompanied by a comprehensive Certificate of Analysis (COA).

                        Packaging & Storage

                        • Packaging: Available in 20mg, 50mg, 100mg, 1g amber glass vials for research purposes. Larger quantities are available upon request .

                        • Storage: Store powder in a tightly sealed container, protected from light, at 2-8°C for up to 2 years, or at -20°C for up to 3 years . For stock solutions, store as aliquots at -20°C for up to 1 month.

                        • Shelf Life: 24-36 months when stored under recommended conditions.

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.