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Home > Food Additives > Nutrition Supplements > L-Tryptophan for Sale > Bulk L-Tryptophan Raw Material Supplier for Worldwide Markets
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Bulk L-Tryptophan Raw Material Supplier for Worldwide Markets

TDS 28 Inquiries

Unit Price:

$4-4.2/KG FOB

Get Latest Price
CAS No.:

73-22-3

Grade:

Pharmaceutical Grade

Content:

99%

Port:

Shanghai

Brand:

ONERBIO

Packaging:

25kg/drum

Sample Available:

Yes

Price valid (until):

2026-10-10

Company Type:
Distributor
Location:
China
Payment Terms:
TT against copy of documents
Average Lead Time:
5 days
Qualification:
Main Products:

Nutrition supplement material,Pharmaceutical raw material,Chemical raw material

  • Product Description

  • Seller Information

  • Inquiry History

  • Description

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    Product Name: L-Tryptophan
    CAS Number: 73-22-3
    Molecular Formula: C₁₁H₁₂N₂O₂
    Molecular Weight: 204.23 g/mol
    Appearance: White to off-white crystalline powder


    L-Tryptophan is a proteinogenic amino acid and an essential dietary component for humans and many animals. It appears as a white to off-white crystalline powder. It is slightly soluble in water, and its solubility increases in aqueous solutions under acidic or basic conditions. It is practically insoluble in nonpolar solvents. The molecule contains an indole side chain, an amino group, and a carboxylic acid group, giving it zwitterionic character near neutral pH. It is optically active and belongs to the L-series. Functionally, L-Tryptophan serves as a precursor for several biologically important substances, including serotonin, melatonin, kynurenine, and auxin-related pathways in plants. It is widely used as a nutritional supplement, a feed additive, and a component in cell culture media. In pharmaceutical and clinical research, it is studied for its role in mood, sleep, immune regulation, and metabolic balance. In food science, it contributes to protein nutrition and can influence flavor formation during processing. It is also used as a chiral building block and analytical standard in chemical and biochemical laboratories. The compound should be stored in a cool, dry, dark place, protected from heat, moisture, and strong oxidizing agents. Handle with standard laboratory precautions.

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    ITEMS

    STANDARDS

    RESULTS

    Description

    White to almost white powder

    White powder

    UV absorbance ratio

    A250/A260

    A280/A260

    0.41-0.49

    2.03-2.71

    0.45

    2.14

    PH

    2.0-4.0

    2.68

    Loss on drying

    ≤5.0%

    2.64%

    Assay (UV)

    ≥98.0%

    99.17%

    Transmittance

    ≥98.5%

    99.1%

    Heavy metals

    ≤10ppm

    <10ppm

    Purity (HPLC)

    ≥98.0%

    99.6%

    Conclusion

    It complies to the standard


    For regulatory compliance (e.g., USP, EP, JP), raw material Vidarabine must meet several rigorous standards:

    • Assay (by HPLC): 98.0% – 102.0% on an anhydrous basis.

    • Related Substances: Limits for specific impurities, notably Ara-Hx (NMT 2.0%), as well as any unspecified individual impurity (NMT 0.1%) and total impurities (NMT 2.0%).

    • Residual Solvents: Must comply with ICH Q3C guidelines (Class 1 and 2 solvents limited or absent).

    • Heavy Metals: NMT 20 ppm (typically lower for injectable grades).

    • Water Content (Karl Fischer): NMT 6.0% (the material is hygroscopic to a degree).

    • Microbial Limits: Total aerobic microbial count (TAMC) ≤ 1000 CFU/g, absence of S. aureus, P. aeruginosa, and Candida albicans.

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    As a high-purity pharmaceutical intermediate, L-Tyrosine Ethyl Ester Hydrochloride is predominantly utilized in the chemical synthesis of bioactive peptides, dopamine analogs, and melanin precursors. Its excellent solubility profile makes it an ideal chiral building block for asymmetric synthesis and a critical substrate in enzymatic reactions. Available in purity grades of ≥98% (HPLC), it meets stringent requirements for R&D and cGMP manufacturing processes. Reliable supply ensures batch-to-batch consistency for long-term project scalability.


    Vidarabine is classified as a potential reproductive hazard and an irritant. Safety Data Sheets (SDS) mandate the following:

    • Hazard Statements (H360): May damage fertility or the unborn child (Category 1B).

    • Precautionary Measures: Use fume hoods and wear impermeable gloves (e.g., nitrile), lab coats, and safety goggles. Avoid generating airborne dust.

    • First Aid: In case of skin contact, wash immediately with copious soap and water. If inhaled, move to fresh air.

    • Storage: Store in tightly sealed, light-resistant containers at 2°C to 8°C (refrigerated) for long-term stability. Avoid freezing.


    While superseded by newer nucleoside analogs (Acyclovir, Ganciclovir) for systemic use due to better bioavailability and lower toxicity, Vidarabine retains niche value. Its primary current application is ophthalmic ointment (3%) . Pharmacokinetically, the raw material has poor oral bioavailability (<10%) and is rapidly deaminated in the gastrointestinal tract, necessitating parenteral or topical administration.


    Vidarabine API is a well-characterized, stable crystalline nucleoside analog. While its systemic use has declined, it remains a critical raw material for topical antiviral ophthalmic preparations, particularly where resistance to other agents occurs. Manufacturers must strictly control impurities (especially Ara-Hx) and water content to ensure final drug product efficacy.

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    ECHEMI Editorial Reference
    L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].
    L-tryptophan is a white powder with a flat taste. An essential amino acid; occurs in isomeric forms. (NTP, 1992)|Solid
    L-tryptophan is a white powder with a flat taste. An essential amino acid; occurs in isomeric forms. (NTP, 1992)|L-tryptophan is the L-enantiomer of tryptophan. It has a role as an antidepressant, a nutraceutical, a micronutrient, a plant metabolite, a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is an erythrose 4-phosphate/phosphoenolpyruvate family amino acid, a proteinogenic amino acid, a tryptophan and a L-alpha-amino acid. It is a conjugate base of a L-tryptophanium. It is a conjugate acid of a L-tryptophanate. It is an enantiomer of a D-tryptophan. It is a tautomer of a L-tryptophan zwitterion.|An essential amino acid that is necessary for normal growth in infants and for nitrogen balance in adults. It is a precursor of indole alkaloids in plants. It is a precursor of serotonin (hence its use as an antidepressant and sleep aid). It can be a precursor to niacin, albeit inefficiently, in mammals.|Tryptophan is the least plentiful of all 22 amino acids and an essential amino acid in humans (provided by food), Tryptophan is found in most proteins and a precursor of serotonin. Tryptophan is converted to 5-hydroxy-tryptophan (5-HTP), converted in turn to serotonin, a neurotransmitter essential in regulating appetite, sleep, mood, and pain. Tryptophan is a natural sedative and present in dairy products, meats, brown rice, fish, and soybeans. (NCI04)|An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.

    Certificates

    Basic Info
    Product Name:

    L-Tryptophan

    Other Name:

    L-Tryptophan;Tryptophan,L-;l-β-3-Indolylalanine;Tryptophane;Tryptophan;L-Tryptophane;1H-Indole-3-propanoic acid,α-amino-,(S)-;L-(-)-Tryptophan;l-α-Aminoindole-3-propionic acid;2-Amino-3-indolylpropanoic acid;(S)-α-Aminoindole-3-propionic acid;(-)-Tryptophan;1H-Indole-3-alanine,(S)-;EH 121;(S)-Tryptophan;(S)-α-Amino-1H-indole-3-propanoic acid;(S)-α-Amino-β-indolepropionic acid;3-Indol-3-ylalanine;L-Alanine,3-(1H-indol-3-yl)-;Lyphan;NSC 13119;(2S)-2-Amino-3-(1H-indol-3-yl)propanoic acid;(S)-2-Amino-3-(1H-indol-3-yl)propanoic acid;(2S)-2-Amino-3-(1H-indol-3-yl)propanoic acid;(2S)-2-Azaniumyl-3-(1H-indol-3-yl)propanoate;6912-86-3;80206-30-0;154635-35-5;2416148-24-6

    CAS No.:

    73-22-3

    Molecular Formula:

    C11H12N2O2

    InChIKeys:

    InChIKey=QIVBCDIJIAJPQS-VIFPVBQESA-N

    Molecular Weight:

    204.22500

    Exact Mass:

    204.23

    EC Number:

    200-795-6

    UNII:

    8DUH1N11BX

    NSC Number:

    757373

    DSSTox ID:

    DTXSID5021419

    NCI Thesaurus Code:

    C29603

    Color/Form:

    Leaflets or plates from dilute alcohol|White to slightly yellowish-white ... crystals or crystalline powder

    ATC Code:

    N - Nervous system

    HScode:

    2933990090

    Categories:

    Nutrition Supplements

    Characteristics
    PSA:

    79.11000

    XLogP3:

    -1.1

    Appearance:

    L-tryptophan is a white powder with a flat taste. An essential amino acid; occurs in isomeric forms. (NTP, 1992)

    Density:

    1.4±0.1 g/cm3

    Melting Point:

    282 °C

    Boiling Point:

    447.9°C at 760 mmHg

    Flash Point:

    224.7±25.9 °C

    Refractive Index:

    1.698

    Water Solubility:

    H2O: 13.4 mg/mL at 25 °C

    Storage Conditions:

    Protect from light

    Vapor Pressure:

    2.1X10-9 mm Hg at 25 deg C (est)

    Toxicity:

    LD508mmol / kg (rat, intraperitoneal injection). It is safe when used in food (FDA, §172.320, 2000).

    Specific rotation:

    Specific optical rotation: -31.5 deg at 23 °C/D (water, 1%), +2.4 deg at 20 °C/D (hydrochloric acid, 0.5 N); +0.15 deg at 20 °C/D (sodium hydroxide, 2.43% in 0.5 N)

    Odor:

    Odorless

    Taste:

    FLAT TASTE

    PH:

    A 1% solution in water has a pH of 5.5 to 7.

    PKA:

    7.38(at 25 °C)

    Dissociation Constants:

    7.38 (at 25 °C)|pK1 = 2.38 /SRC: carboxylic acid/; pK2 = 9.39 /SRC: primary amine/

    Collision Cross Section:

    154.22 Ų [M+H]+ [CCS Type: DT, Method: stepped-field]|158.58 Ų [M-H]- [CCS Type: DT, Method: stepped-field]|145 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine]|150.1 Ų [M+H]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|150.3 Ų [M+H]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|147.6 Ų [M+Na]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|147.7 Ų [M+Na]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|142.3 Ų [M-H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|142.5 Ų [M-H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|151.5 Ų [M-H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|149.1 Ų [M-H]-

    Experimental Properties:

    Decomposes at 289 °C (rapid heating)|Needles from methanol, decomposes at 251 °C /Tryptophan hydrochloride/|UV: 3453 (Sadtler Research Laboratories Spectral Collection) /Tryptophan (DL)/

    Air and Water Reactions:

    Slightly soluble in water.

    Reactive Group:

    Salts, Acidic

    Reactivity Profile:

    Acidic salts, such as L-TRYPTOPHAN, are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.

    Hazard Identification

    Classification of the substance or mixture

    Not classified.

    GHS label elements, including precautionary statements

    Pictogram(s) No symbol.
    Signal word

    No signal word

    Hazard statement(s)

    none

    Precautionary statement(s)
    Prevention

    none

    Response

    none

    Storage

    none

    Disposal

    none

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Protect from light

  • Seller Information
    Business Type:

    Distributor

    Main Products:

    Nutrition supplement material,Pharmaceutical raw material,Chemical raw material

    Location:

    Changqing 5th Road, Jianghan District

    Payment Terms:

    TT against copy of documents

    Average lead Time:

    5 days

    Total Annual Revenue:

    $1 million-$2.5 million

    Total Employees:

    5-10

    Year of Establishment:

    2020

    Wuhan Oner Biotech Co.,Ltd. located in the popular city of Wuhan, specilize in producing and developing pharmaceutical & its intermediates, Cosmetics Raw Material and Intermediate, food additive, Plant extracts,and in distributing the products of our own company. We serves our clients by supplying high-quality.These products are manufactured in ISO 9001 certified plants and have continuously been passing quality inspection by CIQ (China Entry & Exit Inspection and Quarantine Bureau),100% pass rate. Our company has professional staff who deal with chemical R&D and scientific management, and holds several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and Spectrophotometer. We have professional sales team, focus on quality and service, and we have achieved excellent performance over the years. Our company is committed to the development of international market , the products are mainly exported to many countries and regions, such as Europe, America, South-east Asia, the Middle East and Africa etc. With constant efforts and good service, We sincerely hope to establish long-term cooperation and common development with our customers.

  • Inquiry History
    28 Inquiries
    Country Product Purchase Quantity Date Posted
    India

    L-Tryptophan (Vegan Only)

    50.00 KG Mar 24, 2026
    India

    L-Tryptophan powder

    25.00 KG Feb 13, 2025
    Peru

    L-Tryptophan

    3000 KG Sep 20, 2026
    India

    L Tryptophan

    25.00 KG Oct 30, 2025
    United States

    L-Tryptophan

    1 MT Apr 16, 2025
    Egypt

    L-Tryptophan

    1000 KG Jun 27, 2024
    India

    L- Tryptophan 98.5%

    5.00 MT Oct 16, 2025
    Egypt

    L-Tryptophan powder

    100.00 KG Oct 11, 2025
    Greece

    TRYPTOPHAN (Trp, W)

    300.00 KG Sep 25, 2025
    India

    L Tyrptophan 

    1.00 KG Apr 25, 2025
    United Kingdom

    L-Tryptophan powder

    15.00 MT Nov 22, 2024
    United States

    L-Tryptophan Powder

    10 MT Oct 18, 2024
    Russia

    L-Tryptophan

    25 KG Sep 24, 2024
    Slovenia

    L-TRYPTOPHAN

    400 G Jan 9, 2026
    India

    L-Tryptophan

    1 MT Apr 23, 2025
    United Kingdom

    L-Tryptophan powder

    1.00 20' Fcl Apr 2, 2025
    India

    Sodium Hydroxide

    100.00 KG Feb 13, 2025
    India

    L-Tyrosine

    25.00 KG Feb 13, 2025
    United Kingdom

    L-Lysine MonoHCL

    50.00 KG Jun 12, 2025
    India

    Acetic acid/GAA

    1.00 20' Fcl Feb 26, 2024
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