Palmitoyl Tripeptide-5, Palmitoyl-KVK/anti-wrinkle & firming, skin repair

Description

Palmitoyl Tripeptide-5 is a synthetic bioactive signaling peptide. Its INCI name is also Palmitoyl Tripeptide-5, with CAS number 623172-56-5, molecular formula C₃₃H₆₅N₅O₅ and molecular weight 611.9. It consists of a palmitic acid chain linked to the tripeptide sequence of Lysine-Valine-Lysine (Lys-Val-Lys). This structural design improves skin penetration while retaining the signaling activity of the peptide, making it a widely used classic peptide raw material in firming and anti-aging skincare formulations. This product is a high-purity (≥98%, tested by HPLC) white powder with good water solubility and easy formulation incorporation, suitable for the research, development and production of various skincare products.

Key Benefits

The core function of Palmitoyl Tripeptide-5 is "signal-induced collagen stimulation". It mimics the body's native signaling mechanism for collagen synthesis. By upregulating the transforming growth factor-beta (TGF-β) pathway, it sends instructions to skin cells to produce collagen, thereby boosting the generation of type I and type III collagen. As people age, the skin's capacity for collagen synthesis declines and collagen loss accelerates. This ingredient works by replenishing collagen synthesis signals to help alleviate signs of skin aging such as sagging and wrinkles caused by collagen depletion.

Specifically, its effects in skincare formulations include:
Promoting collagen synthesis: Stimulates the production of type I and type III collagen via the TGF-β signaling pathway to improve skin firmness.
Improving the appearance of wrinkles: Helps smooth fine lines and wrinkles, leaving the skin looking smoother and more youthful.
Enhancing elasticity and texture: Boosts skin elasticity and refines skin texture and overall smoothness.
Skin-friendly and readily penetrative: Its palmitoylated structure improves the peptide’s skin permeability and stability, delivering high formulation efficiency.
Mild and easy to formulate with: As a signal peptide raw material, it is gentle and compatible with a wide range of skincare active ingredients.

Applications

Palmitoyl Tripeptide-5 is a well-established anti-aging peptide raw material in the cosmetics industry. It is widely incorporated into formulations of various firming, anti-wrinkle and collagen care skincare products, commonly found in serums, creams, eye creams, masks and other product categories. It can also be combined with other skincare peptides, hyaluronic acid and other active ingredients to achieve synergistic benefits.

Specific application scenarios include:
Anti-wrinkle and firming products: Used in serums, creams, lotions, etc., to improve fine lines and skin sagging.
Periorbital care products: Used in eye creams and eye serums to reduce fine lines and dry lines around the eyes.
Collagen care products: Serves as a core active ingredient in collagen care formulations.
Peptide blending formulas: Can be compounded with other skincare peptides such as Acetyl Hexapeptide and Palmitoyl Pentapeptide for synergistic effects.

Formulation recommendation: The recommended addition level is generally 1%–3% (subject to formulation verification). Add it to the aqueous phase during the cooling stage (below 40℃) and avoid prolonged exposure to high temperatures.