Palmitoyl Tripeptide-8, Neutrazen/soothing/anti-irritation, reduces pro-inflammatory mediators

Description

Palmitoyl Tripeptide-8 is a synthetic lipopeptide cosmetic active ingredient. Its INCI name is Palmitoyl Tripeptide-8, with CAS number 936544-53-5, molecular formula C₃₇H₆₁N₉O₄ and molecular weight 695.94. It is formed by linking palmitic acid with three amino acids, namely histidine, phenylalanine and arginine. The introduction of the palmitic acid chain improves lipophilicity and skin penetration efficiency. This product is a high-purity (≥98%, tested by HPLC) white to off-white powder. It is a widely used neuro-soothing peptide raw material in sensitive skin care, suitable for various soothing and anti-irritating skincare formulations. This product is a cosmetic raw material, not a medicine, and cannot replace drug treatment.

Key Benefits

The core function of Palmitoyl Tripeptide-8 is "neurosoothing". It acts on the neurogenic response pathway of the skin, targeting the neurokinin-1 receptor (NK1R, also known as the substance P receptor). By reducing the release of substance P and related reactive factors, it lessens the skin's overreaction to external irritants, thereby helping relieve discomforts such as redness, burning and stinging, and assisting the skin in maintaining a stable sensitive threshold state.

Specifically, its effects in skincare formulations include:
Neurogenic discomfort soothing: Reduces the release of substance P to ease skin discomforts including stinging, burning and tightness.
Redness and puffiness alleviation: Helps reduce vasodilation responses and improve visible conditions such as erythema and puffiness.
Anti-irritation protection: Lowers the intensity of the skin's reaction to irritants and improves skin tolerance.
Barrier stabilization: Helps maintain and restore the normal sensitive threshold of the skin, suitable for daily stabilizing care of reactive skin.

Applications

Palmitoyl Tripeptide-8 is mainly used in cosmetics for sensitive skin care. It is a popular peptide raw material for product lines such as soothing redness relief and care for special skin conditions. It features mild properties and good compatibility, and can be formulated with a variety of moisturizing and repairing ingredients.
Specific application scenarios include:
Sensitive skin skincare products: specialized formulas for sensitive skin such as soothing serums, anti-redness creams, and stabilizing lotions.
Special-condition skin care: soothing care products for periods after cosmetic procedures and sun exposure.
Post-shave care: alleviating burning, stinging and redness after men's shaving.
Mild care products: soothing active ingredients in low-irritation formulations (children's products need to separately comply with regulatory requirements of target markets).
Formulation combinations: can be used with soothing and repairing ingredients such as centella asiatica, ceramides and other signal peptides.