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N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide

N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide structure

CAS No:
439081-18-2
Formula:
C24H25ClFN5O3
Chemical Name:
N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide
Synonyms:
2-Butenamide,N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-;N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide;915958-11-1
Categories:
Active Pharmaceutical Ingredients > Inhibitor Drugs

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N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide Basic Attributes

Molecular Weight：

485.944

Exact Mass：

485.94

HScode：

2934999090

Characteristics

PSA：

88.6

XLogP3：

3.59

Density：

1.380

Melting Point：

100 - 102 °C

Boiling Point：

676.9±55.0 °C at 760 mmHg

Flash Point：

363.2±31.5 °C

Refractive Index：

1.668

Safety Information

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide Use and Manufacturing

BIBW 2992 is an anilino-quinazoline that irreversibly inhibits EGFR and HER2 kinase activity. Afatinib is an aminocrotonylamino-substituted quinazoline derivative used to treat cancers and diseases of the respiratory tract, lung, gastrointestinal tract, bile duct and gallbladder.

Recommended Suppliers of N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide

Chong Da Prostaglandin Fine Chemicals Co., Ltd Contact Supplier

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CAS No.: 439081-18-2

Grade: Pharmaceutical Grade

Content: 99.7%

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CAS No.: 439081-18-2

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Hangzhou Chungyo Chemicals Co., Ltd. Contact Supplier

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Guide of N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide

Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Recommended Suppliers
Learn More Other Chemicals

N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide

SDS

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