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Glatiramer acetate

Glatiramer acetate structure

CAS No:
147245-92-9
Formula:
(C9H11NO3.C6H14N2O2.C5H9NO4.C3H7NO2)x.xC2H4O2
Chemical Name:
Glatiramer acetate
Synonyms:
L-Glutamic acid,polymer with L-alanine,L-lysine and L-tyrosine,acetate (salt);L-Alanine,polymer with L-glutamic acid,L-lysine and L-tyrosine,acetate (salt);L-Lysine,polymer with L-alanine,L-glutamic acid and L-tyrosine,acetate (salt);L-Tyrosine,polymer with L-alanine,L-glutamic acid and L-lysine,acetate (salt);L-Glutamic acid peptide with L-alanine,L-lysine and L-tyrosine,acetate (salt);Cop 1;Cop 1 (polyamide);Glatiramer acetate;Copaxone;Copolymer 1;Protiramer;TV 5010;511: PN: WO2010103292 PAGE: 64 claimed sequence;Probioglat;Polimunol;Escadra;Natco;Hangzhou;Axoglatiran FS;Glatopa;M 356;943513-95-9
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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Glatiramer acetate Basic Attributes

Molecular Weight：

623.65

Exact Mass：

623.30100

Characteristics

PSA：

374

XLogP3：

2.14760

Boiling Point：

385.2ºC at 760mmHg

Flash Point：

186.7ºC

Vapor Pressure：

1.27E-06mmHg at 25°C

Safety Information

Precautionary statement(s)：

P261, P264, P272, P280, P285, P302+P352, P304+P341, P305+P351+P338, P321, P332+P313, P333+P313, P337+P313, P342+P311, P362, P363, P501

Hazard Statements：

H315

Glatiramer acetate Use and Manufacturing

Glatiramer acetate (also known as Copolymer 1, Cop-1, or Copaxone - as marketed by Teva Pharmaceuticals) is an immunomodulator drug currently used to treat multiple sclerosis. It is a random polymer of four amino acids found in myelin basic protein, namely glutamic acid, lysine, alanine, and tyrosine, and may work as a decoy for the immune system. Glatiramer acetate is approved by the Food and Drug Administration (FDA) for reducing the frequency of relapses, but not for reducing the progression of disability. Observational studies, but not randomized controlled trials, suggest that it may reduce progression of disability.Although the clinical definition of multiple sclerosis requires two or more episodes of symptoms and signs, glatiramer acetate is approved for treatment after single episodes. It is also used to treat relapsing-remitting multiple sclerosis. It is administered by subcutaneous injection.

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