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Org 25969

Org 25969 structure

CAS No:
343306-79-6
Formula:
C72H112O48S8.8Na
Chemical Name:
Org 25969
Synonyms:
γ-Cyclodextrin,6A,6B,6C,6D,6E,6F,6G,6H-octakis-S-(2-carboxyethyl)-6A,6B,6C,6D,6E,6F,6G,6H-octathio-,sodium salt (1:8);γ-Cyclodextrin,6A,6B,6C,6D,6E,6F,6G,6H-octakis-S-(2-carboxyethyl)-6A,6B,6C,6D,6E,6F,6G,6H-octathio-,octasodium salt;Org 25969;Sugammadex sodium;6-Per-deoxy-6-per-(2-carboxyethyl)thio-γ-cyclodextrin sodium salt;Sugammadex sodium salt;862667-16-1;1202253-72-2
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Sugammadex sodium is a synthetic γ-cyclodextrin derivative, and acts as a new reversal agent for neuromuscular block.

Sugammadex sodium is an organic sodium salt that is the octasodium salt of sugammadex. Used for reversal of neuromuscular blockade induced by rocuronium and vecuronium in adults undergoing surgery. It has a role as a neuromuscular agent. It contains a sugammadex(8-).|Sugammadex Sodium is the sodium salt form of sugammadex, a biologically inert, selective relaxant binding agent (SRBA) composed of a modified, anionic gamma cyclodextrin derivative containing a hydrophilic exterior and a hydrophobic core, with neuromuscular blocking drug (NMBD) reversal activity. Upon administration, the negatively charged carboxyl-thio-ether groups of sugammadex selectively and reversibly bind to the positively charged quaternary nitrogen of a steroidal NMBD, such as rocuronium and vecuronium, which was administered at an earlier time for anesthetic purposes. The encapsulation of the NMBD by sugammadex blocks its ability to bind to nicotinic receptors in the neuromuscular junction and thereby reverses the NMBD-induced neuromuscular blockade.|A gamma-cyclodextrin that functions as a reversal agent for the neuromuscular blocker ROCURONIUM BROMIDE.

Org 25969 Basic Attributes

Molecular Weight：

2177.974

Exact Mass：

2176.26000

EC Number：

608-974-4

UNII：

ERJ6X2MXV7

NCI Thesaurus Code：

C78123

ATC Code：

V03AB35|V - Various

Characteristics

PSA：

995

Density：

1.275g/cm3 （计算值）

Safety Information

GHS Classification：

|Warning|H302 (98.11%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 58 companies from 3 notifications to the ECHA C&L Inventory.

Drug Information

Drug Indication：

Reversal of neuromuscular blockade induced by rocuronium or vecuronium.For the peadiatric population: sugammadex is only recommended for routine reversal of rocuronium-induced blockade in children and adolescents.

MeSH Entry Terms：

6-perdeoxy-6-per(2-carboxyethyl)thio-gamma-cyclodextrin sodium salt

Org 25969 Use and Manufacturing

Uses

Reversal agent for neuromuscular blocking drugs.

Use Classification：

Human drugs -> Bridion -> EMA Drug Category|All other therapeutic products -> Human pharmacotherapeutic group|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:2178.0
Hydrogen Bond Donor Count:16
Hydrogen Bond Acceptor Count:56
Rotatable Bond Count:32
Exact Mass:2176.2644287
Monoisotopic Mass:2176.2644287
Topological Polar Surface Area:995
Heavy Atom Count:136
Complexity:2790
Defined Atom Stereocenter Count:40
Covalently-Bonded Unit Count:9
Compound Is Canonicalized:Yes

Related Drugs

Sugammadex Sodium Injection
Ingredients	Active ingredient: Sugammadex Sodium
Specifications	2ml:200mg/bottle*10bottles/box

Registered Holders

MANKIND PHARMA LTD

United States
Active
MSN LIFE SCIENCES PRIVATE LTD

United States
Active
HONOUR LAB LTD

United States
Active

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