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Coluracetam

Coluracetam structure

CAS No:
135463-81-9
Formula:
C19H23N3O3
Chemical Name:
Coluracetam
Synonyms:
1-Pyrrolidineacetamide,2-oxo-N-(5,6,7,8-tetrahydro-2,3-dimethylfuro[2,3-b]quinolin-4-yl)-;Furo[2,3-b]quinoline,1-pyrrolidineacetamide deriv.;2-Oxo-N-(5,6,7,8-tetrahydro-2,3-dimethylfuro[2,3-b]quinolin-4-yl)-1-pyrrolidineacetamide;MKC 231;Coluracetam
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

Coluracetam(MKC-231) is a new choline uptake enhancer.IC50 value:Target:in vitro: MKC-231 (10(-10)-10(-6) moll) significantly increased high affinity choline uptake (HACU) when it was incubated with the hippocampal synaptosomes of ethylcholine mustard aziridinium ion (AF64A) treated rats, but not of normal rats. MKC-231 did not affect the AChE activity, [3H]- quinuclidinyl benzilate binding, and [3H]-pirenzepine binding [1].in vivo: Oral administration of MKC-231 (1-10 mg/kg) significant

Coluracetam Basic Attributes

Molecular Weight：

341.4

Exact Mass：

341.40

EC Number：

1308068-626-2

UNII：

V6FL6O5GR7

DSSTox ID：

DTXSID60159386

HScode：

2934999090

Characteristics

PSA：

75.4

XLogP3：

2.4

Density：

1.291±0.06 g/cm3(Predicted)

Boiling Point：

634.1±55.0 °C(Predicted)

Flash Point：

337.3±31.5 °C

Refractive Index：

1.641

Drug Information

MeSH Entry Terms：

2-(2-oxypyrrolidin-1-yl)-N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro(2,3-b)quinolin-4-yl)acetoamide

Computed Properties

Molecular Weight:341.4
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:341.17394160
Monoisotopic Mass:341.17394160
Topological Polar Surface Area:75.4
Heavy Atom Count:25
Complexity:540
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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