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Cinepazide

Cinepazide structure

CAS No:
23887-46-9
Formula:
C22H31N3O5
Chemical Name:
Cinepazide
Synonyms:
2-Propen-1-one,1-[4-[2-oxo-2-(1-pyrrolidinyl)ethyl]-1-piperazinyl]-3-(3,4,5-trimethoxyphenyl)-;Piperazine,1-[(1-pyrrolidinylcarbonyl)methyl]-4-(3,4,5-trimethoxycinnamoyl)-;Piperazine,1-[2-oxo-2-(1-pyrrolidinyl)ethyl]-4-[1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]-;1-[4-[2-Oxo-2-(1-pyrrolidinyl)ethyl]-1-piperazinyl]-3-(3,4,5-trimethoxyphenyl)-2-propen-1-one;Cinepazide;47658-44-6
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

Cinepazide is a vasodilator.Target: OthersCinepazide is a vasodilator. Cinepazide (30 mg/kg, i.v.) potentiated the vertebral vasodilator response of dogs to intravertebral adenosine and cyclic AMP, Intravertebral cinepazide(1-10 mg) increased vertebral blood flow in a dose-related manner and the effect was partially inhibited by intravenous pretreatment with aminophylline but not by pretreatment with autonomic antagonists. Cinepazide resembled cinnarizine and papaverine in that the drug

Cinepazide Basic Attributes

Molecular Weight：

417.5

Exact Mass：

417.50

EC Number：

245-928-9

Characteristics

PSA：

71.6

XLogP3：

1.64

Appearance：

white powder

Density：

1.2±0.1 g/cm3

Melting Point：

170 - 175ºC

Boiling Point：

637.8±55.0 °C at 760 mmHg

Flash Point：

339.5±31.5 °C

Refractive Index：

1.575

Vapor Pressure：

3.65E-16mmHg at 25°C

Computed Properties

Molecular Weight:417.5
XLogP3:1.5
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:417.22637110
Monoisotopic Mass:417.22637110
Topological Polar Surface Area:71.6
Heavy Atom Count:30
Complexity:586
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes