3-Bromo-4-quinolinamine

The reaction flask was added with 34.6 g (240 mmol) of 4-aminoquinoline and dissolved in 76 mL of glacial acetic acid. The mixture was cooled to 0 ° C and a solution of 42.2 g (264 mmol) of liquid bromine in 100 mL of glacial acetic acid was added dropwise with stirring. , A solid precipitation, the product in acetic acid solubility is small, after dripping, room temperature stirring for 30 minutes. Add 1520mL of ether to the mixture, the filter to get the precipitate. The product was dissolved in 800 mL of water (most of which was dissolved in cold water and most of the heated reflux). The solution was made basic with 1N aqueous sodium hydroxide solution to precipitate a large amount of solid. The precipitate was collected by suction filtration, washed with 800 mL of water and dried in a vacuum oven under reduced pressure to give 44.16 g of 4-amino-3-bromoquinoline as an off-white product in 82percent yield. M.p 200.6 ~ 201.7 ° C.

Molecular Weight:223.07
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:221.97926
Monoisotopic Mass:221.97926
Topological Polar Surface Area:38.9
Heavy Atom Count:12
Complexity:163
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes