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Anisodamine

Anisodamine structure

Anisodamine 

structure
  • CAS No:

    55869-99-3

  • Formula:

    C17H23NO4

  • Chemical Name:

    Anisodamine

  • Synonyms:

    Benzeneacetic acid,α-(hydroxymethyl)-,(1R,3S,5R,6S)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester,(αS)-;Benzeneacetic acid,α-(hydroxymethyl)-,6-hydroxy-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester,[1R-[1α,3β(S*),5α,6α]]-;Hyoscyamine,6-hydroxy-;6-Hydroxyhyoscyamine;Anisodamine;6β-Hydroxyhyoscyamine;(-)-6β-Hydroxyhyoscyamine;(-)-(3S,6S,2′S)-6β-Hydroxyhyoscyamine;(-)-Anisodamine;39459-41-1;52646-91-0

  • Categories:

    Active Pharmaceutical Ingredients  >  Nervous System Drugs

Description

Anisodamine is an anticholinergic and α1-adrenergic receptor antagonist used in the treatment of acute circulatory shock, is also a naturally occurring tropane alkaloid found in some plants of the Solanaceae family.

Anisodamine Basic Attributes

305.37

305.37

DTXSID00425118

Characteristics

70.00000

0.83960

1.27

62-63 °C

423.1ºC at 760 mmHg

1.565

H2O: ≥5mg/mL

room temp

170.9 Ų [M+H]+ [CCS Type: DT, Method: single field calibrated]

Safety Information

NONH for all modes of transport

3

P301 + P312 + P330-P305 + P351 + P338

H302-H319

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P280, P301+P312, P305+P351+P338, P330, P337+P313, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)|Drugs that selectively bind to and activate alpha adrenergic receptors. (See all compounds classified as Adrenergic alpha-Agonists.)|Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)|Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief. (See all compounds classified as Anti-Ulcer Agents.)|Substances that eliminate free radicals. Among other effects, they protect PANCREATIC ISLETS against damage by CYTOKINES and prevent myocardial and pulmonary REPERFUSION INJURY. (See all compounds classified as Free Radical Scavengers.)|Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)|Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

6-hydroxyhyoscyamine

Computed Properties

Molecular Weight:305.4
XLogP3:0.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:305.16270821
Monoisotopic Mass:305.16270821
Topological Polar Surface Area:70
Heavy Atom Count:22
Complexity:396
Undefined Atom Stereocenter Count:5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Antispasmodic, bronchodilator

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

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