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8-Bromo-7-quinolinol

8-Bromo-7-quinolinol structure

CAS No:
90224-71-8
Formula:
C9H6BrNO
Chemical Name:
8-Bromo-7-quinolinol
Synonyms:
8-Bromo-7-quinolinol;7-Hydroxy-8-bromo-quinoline;8-broMoquinolin-7-ol;8-Bromo-7-hydroxyquinoline
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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8-Bromo-7-quinolinol Basic Attributes

Molecular Weight：

224.05

Exact Mass：

222.963272

EC Number：

DSSTox ID：

DTXSID60676407

HScode：

2933990090

Characteristics

PSA：

29.1

XLogP3：

1.9

Density：

1.705

Melting Point：

196-198℃

Boiling Point：

327.9±22.0°C at 760 mmHg

Flash Point：

152.1±22.3 °C

Refractive Index：

1.718

Safety Information

safety instructions：

26-37-60

Drug Information

MeSH Entry Terms：

8-bromo-7-hydroxyquinoline

8-Bromo-7-quinolinol Use and Manufacturing

Step 2: 8-Bromo-7-hydroxyquinoline[0152] To a stirred solution of 7-hydroxyquinoline (59.0 g, 0.406 mol) in AcOH (120 mL) and CHStep 2: 8-Bromo-7-hydroxyquinoline[0152] To a stirred solution of 7-hydroxyquinoline (59.0 g, 0.406 mol) in AcOH (120 mL) and CH2Cl2 (240 mL) was slowly added bromine (22.9 ml, 0.444 mol) in AcOH (120 ml) while keeping the internal temperature at 0 - 5 0C. The resulting suspension was stirred for 2 h at 0~5 0C, and thendiluted with EtOAc (100 rnL) and filtered. The solid was washed withEtOAc (2 x 20 mL) and dried in vacuo to give 8-bromo-7-hydroxyquinoline (65 g, 76%).

Computed Properties

Molecular Weight:224.05
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:222.96328
Monoisotopic Mass:222.96328
Topological Polar Surface Area:33.1
Heavy Atom Count:12
Complexity:165
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes