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Alfacalcidol

Alfacalcidol structure

CAS No:
41294-56-8
Formula:
C27H44O2
Chemical Name:
Alfacalcidol
Synonyms:
1,3-Cyclohexanediol,5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R)-1,5-dimethylhexyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-,(1R,3R)-;9,10-Secocholesta-5,7,10(19)-triene-1,3-diol,(1α,3β,5Z,7E)-;(1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R)-1,5-Dimethylhexyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-cyclohexanediol;1α-Hydroxycholecalciferol;1α-Hydroxyvitamin D3;1-Hydroxycholecalciferol;1-Hydroxyvitamin D3;Alfacalcidol;Un Alpha;α-Calcidol;Alfarol;Alphacalcidol;Oxydevit;Alpharol;Bondiol;Un Alfa;Etalpha;1α(OH)D3;Alpha D3;EinsAlpha;(1S)-Hydroxycalciol;Tevabone;125324-15-4;41461-06-7;43157-29-5;43217-90-9
Categories:
Active Pharmaceutical Ingredients > Vitamins and Minerals Medicines

Description

Alfacalcidol (1-hydroxycholecalciferol; Alpha D3; 1.alpha.-Hydroxyvitamin D3) is a non-selective VDR activator medication. IC50 value: Target: VDR activatorAlfacalcidol (1-hydroxycholecalciferol; Alpha D3; 1.alpha.-Hydroxyvitamin D3) improves mechanical bone strength and bone mass; suppresses osteoclastic bone resorption in vivo.

Alfacalcidol Basic Attributes

Molecular Weight：

400.64

Exact Mass：

400.64

EC Number：

255-297-1

DSSTox ID：

DTXSID0022569

ATC Code：

A - Alimentary tract and metabolism

HScode：

29361000

Characteristics

PSA：

40.46000

XLogP3：

8.31

Appearance：

Solid

Density：

1.0±0.1 g/cm3

Melting Point：

136 °C

Boiling Point：

531.5±50.0 °C at 760 mmHg

Flash Point：

222.6±24.7 °C

Refractive Index：

1.534

Water Solubility：

1.63e-03 g/L

Storage Conditions：

−20°C

Safety Information

Packing level：

Hazard category：

6.1(a)

Transport codes：

UN 2811 6.1/PG 1

wgk germany：

hazard class code：

26/27/28-36/37/38

safety instructions：

28-36/37-45-36-26

RTECS Number：

VS2851000

Marks：

T+,Xi

Precautionary statement(s)：

Missing Phrase - N15.00950417-P260-P262-P280-P302 + P352 + P310-P304 + P340 + P310

Hazard Statements：

H300 + H310 + H330

GHS Classification：

|Danger|H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]|P260, P262, P264, P270, P271, P280, P284, P301+P310, P302+P350, P304+P340, P310, P320, P321, P322, P330, P361, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 47 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS. (See all compounds classified as Bone Density Conservation Agents.)

MeSH Entry Terms：

1 alpha-hydroxycholecalciferol

Alfacalcidol Use and Manufacturing

A synthetic analog of Calcitiol (the hormonal form of vitamin D3), which shows identical potency with respect to stimulation of intestinal calcium absorption and bone mineral mobilization. Vitamin D source

Computed Properties

Molecular Weight:400.6
XLogP3:6.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:400.334130642
Monoisotopic Mass:400.334130642
Topological Polar Surface Area:40.5
Heavy Atom Count:29
Complexity:643
Undefined Atom Stereocenter Count:6
Undefined Bond Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Alfacalcidol

Alfacalcidol Soft Capsules
Ingredients	The main ingredients of this product are: Alfacalcidol. Structural formula: Molecular formula: C27H44O2 Molecular weight: 400.65
Indication	1 Calcium agents: Combination with calcium agents may cause elevated blood calcium, so blood calcium should be monitored. 2 Thiazide diuretics: This type of diuretic can promote the kidney's absorption of calcium, and there is a risk of hypercalcemia when used together. 3 Digitalis glycosides: Hypercalcemia in patients taking digitalis drugs can easily induce arrhythmias. If this drug is used in combination, blood calcium should be closely monitored. 4 Barbiturates, anticonvulsants: These drugs can accelerate the metabolism of active vitamin D metabolites in the liver and reduce the efficacy of the drug, so the dose of this drug should be appropriately increased. 5 Gastrointestinal absorption inhibitors: Cholestyramine or aluminum-containing antacids can reduce the absorption of this drug. The two should not be taken at the same time. The drugs should be taken one after the other with an interval of 2 hours. 6 Phosphorus agents: This product can induce hyperphosphatemia when used in combination with large doses of phosphorus agents.
Specifications	0.25 μg

Alfacalcidol Soft Capsules
Ingredients	Alfacalcidol.
Indication	1 Calcium agents: Combination with calcium agents may cause elevated blood calcium, so blood calcium should be monitored. 2 Thiazide diuretics: This type of diuretic can promote the kidney's absorption of calcium, and there is a risk of hypercalcemia when used together. 3 Digitalis glycosides: Hypercalcemia in patients taking digitalis drugs can easily induce arrhythmias. If this drug is used in combination, blood calcium should be closely monitored. 4 Barbiturates, anticonvulsants: These drugs can accelerate the metabolism of active vitamin D metabolites in the liver and reduce the efficacy of the drug, so the dose of this drug should be appropriately increased. 5 Gastrointestinal absorption inhibitors: Cholestyramine or aluminum-containing antacids can reduce the absorption of this drug. The two should not be taken at the same time, and should be taken 2 hours apart.
Specifications	0.25 μg
Manufacturer	Guangzhou Baiyunshan Xingqun Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

FORMOSA LABORATORIES, INC.

China
Active
Beijing Ansenbo Pharmaceutical Technology Co., Ltd.

China
Active
Qingdao Guoxin Pharmaceutical Co., Ltd.

China
Active

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