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Hematoporphyrin

Hematoporphyrin structure

CAS No:
14459-29-1
Formula:
C34H38N4O6
Chemical Name:
Hematoporphyrin
Synonyms:
21H,23H-Porphine-2,18-dipropanoic acid,7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-;2,18-Porphinedipropionic acid,7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-;Hematoporphyrin IX;7,12-Bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoic acid;Hematoporphyrin;HP;Photodyn;1,3,5,8-Tetramethyl-2,4-bis(α-hydroxyethyl)porphine-6,7-dipropionic acid;7,12-Bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-2,18-porphinedipropionic acid;NSC 59265;NSC 267084;HpIX;553-11-7;19710-66-8;20098-28-6;47852-79-9;119546-75-7;127160-44-5;142168-20-5;221889-19-6;227474-98-8;343862-38-4;885267-30-1;1201812-91-0;1337567-66-4
Categories:
Dyes and Pigments > Pigment

Description

ChEBI: A dicarboxylic acid that is protoporphyrin in which the vinyl groups at positions 7 and 12 are replaced by 1-hydroxyethyl groups.

Hematoporphyrin is a dicarboxylic acid that is protoporphyrin in which the vinyl groups at positions 7 and 12 are replaced by 1-hydroxyethyl groups. It has a role as a photosensitizing agent. It is a member of protoporphyrins and a dicarboxylic acid. It derives from a protoporphyrin.|Iron-free derivatives of heme with 4 methyl groups, 2 hydroxyethyl groups and 2 propionic acid groups attached to the pyrrole rings. Some of these PHOTOSENSITIZING AGENTS are used in the PHOTOTHERAPY of malignant NEOPLASMS.

Hematoporphyrin Basic Attributes

Molecular Weight：

598.69

Exact Mass：

598.69

EC Number：

238-450-7

UNII：

HBT6M5H379

NSC Number：

267084|59265

Characteristics

PSA：

172

XLogP3：

5.95

Density：

1.328

Melting Point：

172.5 °C

Boiling Point：

649.58°C (rough estimate)

Flash Point：

667.3±34.3 °C

Refractive Index：

1.6000 (estimate)

Storage Conditions：

2-8°C

Collision Cross Section：

248.4 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

wgk germany：

safety instructions：

22-24/25

RTECS Number：

TS5500000

Drug Information

MeSH：

Drugs that are pharmacologically inactive but when exposed to ultraviolet radiation or sunlight are converted to their active metabolite to produce a beneficial reaction affecting the diseased tissue. These compounds can be administered topically or systemically and have been used therapeutically to treat psoriasis and various types of neoplasms. (See all compounds classified as Photosensitizing Agents.)

MeSH Entry Terms：

Haematoporphyrin IX

Hematoporphyrin Use and Manufacturing

antidepressant, antineoplastic

Computed Properties

Molecular Weight:598.7
XLogP3:2.1
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:8
Exact Mass:598.27913494
Monoisotopic Mass:598.27913494
Topological Polar Surface Area:172
Heavy Atom Count:44
Complexity:1020
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

This product, when used in combination with laser, can kill cancer cells.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Hematoporphyrin
Manufacturer	Chongqing Huading Modern Bio-pharmaceutical Liability Company

Hematoporphyrin injection
Ingredients	Hematoporphyrin
Indication	Not yet clear.
Specifications	20ml:0.1g
Manufacturer	Chongqing Huading Modern Bio-pharmaceutical Liability Company

Hematoporphyrin injection
Ingredients	Hematoporphyrin
Indication	Not yet clear.
Specifications	5ml:25mg
Manufacturer	Chongqing Huading Modern Bio-pharmaceutical Liability Company

Registered Holders

Chongqing Huading Modern Bio-pharmaceutical Liability Company

China
Active
ROUSSEL CORP

United States
Inactive

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HEMATOPORPHYRIN CAS 14459-29-1 for Scientific Research Chemical Reagents Use only

CAS No.: 14459-29-1

Grade: Pharmaceutical Grade

Content: 99%

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