Hematoporphyrin
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Hematoporphyrin
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CAS No:
14459-29-1
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Formula:
C34H38N4O6
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Chemical Name:
Hematoporphyrin
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Synonyms:
21H,23H-Porphine-2,18-dipropanoic acid,7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-;2,18-Porphinedipropionic acid,7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-;Hematoporphyrin IX;7,12-Bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoic acid;Hematoporphyrin;HP;Photodyn;1,3,5,8-Tetramethyl-2,4-bis(α-hydroxyethyl)porphine-6,7-dipropionic acid;7,12-Bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-2,18-porphinedipropionic acid;NSC 59265;NSC 267084;HpIX;553-11-7;19710-66-8;20098-28-6;47852-79-9;119546-75-7;127160-44-5;142168-20-5;221889-19-6;227474-98-8;343862-38-4;885267-30-1;1201812-91-0;1337567-66-4
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CAS No:
Description
ChEBI: A dicarboxylic acid that is protoporphyrin in which the vinyl groups at positions 7 and 12 are replaced by 1-hydroxyethyl groups.
Hematoporphyrin is a dicarboxylic acid that is protoporphyrin in which the vinyl groups at positions 7 and 12 are replaced by 1-hydroxyethyl groups. It has a role as a photosensitizing agent. It is a member of protoporphyrins and a dicarboxylic acid. It derives from a protoporphyrin.|Iron-free derivatives of heme with 4 methyl groups, 2 hydroxyethyl groups and 2 propionic acid groups attached to the pyrrole rings. Some of these PHOTOSENSITIZING AGENTS are used in the PHOTOTHERAPY of malignant NEOPLASMS.
Characteristics
172
5.95
1.328
172.5 °C
649.58°C (rough estimate)
667.3±34.3 °C
1.6000 (estimate)
2-8°C
248.4 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Drug Information
Drugs that are pharmacologically inactive but when exposed to ultraviolet radiation or sunlight are converted to their active metabolite to produce a beneficial reaction affecting the diseased tissue. These compounds can be administered topically or systemically and have been used therapeutically to treat psoriasis and various types of neoplasms. (See all compounds classified as Photosensitizing Agents.)
Haematoporphyrin IX
Computed Properties
Molecular Weight:598.7
XLogP3:2.1
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:8
Exact Mass:598.27913494
Monoisotopic Mass:598.27913494
Topological Polar Surface Area:172
Heavy Atom Count:44
Complexity:1020
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
This product, when used in combination with laser, can kill cancer cells.
Registered Holders
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Chongqing Huading Modern Bio-pharmaceutical Liability Company
Active![China]()
China
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ROUSSEL CORP
Inactive![United States]()
United States
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