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Rivastigmine tartrate

Rivastigmine tartrate structure

CAS No:
129101-54-8
Formula:
C14H22N2O2.C4H6O6
Chemical Name:
Rivastigmine tartrate
Synonyms:
Carbamic acid,N-ethyl-N-methyl-,3-[(1S)-1-(dimethylamino)ethyl]phenyl ester,(2R,3R)-2,3-dihydroxybutanedioate (1:1);Carbamic acid,ethylmethyl-,3-[1-(dimethylamino)ethyl]phenyl ester,(S)-,[R-(R*,R*)]-2,3-dihydroxybutanedioate (1:1);Carbamic acid,ethylmethyl-,3-[(1S)-1-(dimethylamino)ethyl]phenyl ester,(2R,3R)-2,3-dihydroxybutanedioate (1:1);SDZ-ENA 713;ENA 713;Rivastigmine hydrogentartrate;Rivastigmine tartrate;rivastigmine bitartrate;123441-04-3
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

White to Off-White PowderChEBI: A tartrate salt obtained by reaction of rivastigmine with one equivalent of (R,R)-tartaric acid. A reversible cholinesterase inhibitor.

Rivastigmine tartrate Basic Attributes

Molecular Weight：

400.42

Exact Mass：

400.184570

EC Number：

1308068-626-2

HScode：

29242990

Characteristics

PSA：

148

XLogP3：

0.63710

Appearance：

White to Off-White Powder

Melting Point：

123-124 °C

Boiling Point：

316.2°C at 760 mmHg

Flash Point：

145ºC

Water Solubility：

H2O: soluble15mg/mL, clear

Storage Conditions：

-20°C Freezer

Vapor Pressure：

0.000416mmHg at 25°C

Specific rotation：

D20 +4.7° (c = 5 in ethanol)

Safety Information

Packing level：

III

Hazard category：

6.1

Transport codes：

UN 2811 6.1 / PGII

wgk germany：

safety instructions：

RTECS Number：

FA9550000

Marks：

Rivastigmine tartrate Use and Manufacturing

Nootropic& Alzheimer’s treatment

Computed Properties

Molecular Weight:400.4
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:8
Exact Mass:400.18456586
Monoisotopic Mass:400.18456586
Topological Polar Surface Area:148
Heavy Atom Count:28
Complexity:402
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Rivastigmine Bitartrate Capsules
Specifications	6.0mg

Rivastigmine Bitartrate Capsules
Specifications	4.5mg

Rivastigmine Bitartrate Capsules
Ingredients	Chemical name: (S)-N-ethyl-N-methyl-3-[l-(dimethylamino)ethyl]-phenylcarbamate, hydrogen-(2R,3R)-tartaric acid Inactive ingredients: gelatin, red iron oxide (E172), yellow iron oxide (E172), magnesium stearate, methylhydroxypropyl cellulose, microcrystalline cellulose, red iron oxide (E172), printing ink
Indication	Because of their pharmacological effects, cholinesterase inhibitors may have vagal effects on heart rate. Therefore, as with other cholinergic drugs, caution must be exercised when administering this drug to patients with sick sinus syndrome (SSS) or other heart blocks (see
Specifications	4.5mg

See More Related Drugs

Registered Holders

JUBILANT BIOSYS LTD

United States
Active
ORBION PHARMACEUTICALS PRIVATE LTD

United States
Active
APITORIA PHARMA PRIVATE LTD

United States
Active

See More Registered Holders

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