 Home > Encyclopedia > Benserazide hydrochloride

Benserazide hydrochloride

Benserazide hydrochloride structure

CAS No:
14919-77-8
Formula:
C10H15N3O5.ClH
Chemical Name:
Benserazide hydrochloride
Synonyms:
Serine,2-[(2,3,4-trihydroxyphenyl)methyl]hydrazide,hydrochloride (1:1);Serine,2-(2,3,4-trihydroxybenzyl)hydrazide,monohydrochloride;DL-Serine,2-[(2,3,4-trihydroxyphenyl)methyl]hydrazide,monohydrochloride;Serine,2-[(2,3,4-trihydroxyphenyl)methyl]hydrazide,monohydrochloride;N-(DL-Seryl)-N′-(2,3,4-trihydroxybenzyl)hydrazine hydrochloride;N′-(DL-Seryl)-N′′-(2,3,4-trihydroxybenzyl)hydrazine hydrochloride;Benserazide hydrochloride;DL-Serine N2-(2,3,4-trihydroxybenzyl)hydrazide hydrochloride;Ro 4-4602;Ro 4-4602/001;14046-64-1;31796-68-6
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

White Crystalline SolidChEBI: A hydrochloride that is the monohydrochloride salt of benserazide. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as an adjunct to levodopa in the treatment of park nsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide h

Benserazide hydrochloride is a hydrochloride that is the monohydrochloride salt of benserazide. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as an adjunct to levodopa in the treatment of parkinsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide hydrochloride has no antiparkinson actions when given alone. It has a role as an antiparkinson drug, an EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor and a dopaminergic agent. It contains a benserazide(1+).

Benserazide hydrochloride Basic Attributes

Molecular Weight：

293.7

Exact Mass：

293.077850

EC Number：

238-991-9

NSC Number：

755907

DSSTox ID：

DTXSID0045412

HScode：

29280000

Characteristics

PSA：

148

XLogP3：

0.52790

Appearance：

solid

Melting Point：

146-148 °C

Boiling Point：

574.2ºC at 760 mmHg

Water Solubility：

soluble in water, dimethyl sulfoxide and methanol. Insoluble in ethanol and acetone.H2O: 10 mg/mL

Storage Conditions：

-20°C Freezer

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36

RTECS Number：

VT9632300

Marks：

Precautionary statement(s)：

P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H315 (43.48%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 92 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Benserazide hydrochloride Use and Manufacturing

Uses

Antiparkinsonian;DOPA decarboxylase inhibitor

Use Classification：

Human drugs -> Rare disease (orphan)

Computed Properties

Molecular Weight:293.70
Hydrogen Bond Donor Count:8
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:5
Exact Mass:293.0778483
Monoisotopic Mass:293.0778483
Topological Polar Surface Area:148
Heavy Atom Count:19
Complexity:278
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Peripheral decarboxylase inhibitors are not easy to enter the central nervous system, and only inhibit the conversion of peripheral levodopa into dopamine, thereby reducing the adverse effects of levodopa on the peripheral cardiovascular system and reducing the dosage of levodopa.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Dopamine Capsules
Ingredients	This product is a compound preparation, its components are: levodopa and benserazide hydrochloride.
Indication	1. This product combined with non-selective monoamine oxidase inhibitors may cause acute adrenal crisis. 2. This product combined with papaverine or vitamin B6 may reduce the efficacy of this product. 3. This product combined with acetylspiramycin can significantly reduce the blood concentration of this product and weaken the efficacy. 4. This product combined with reserpine can inhibit the effect of this product and should be avoided. 5. This product combined with antipsychotic drugs should be avoided because the two antagonize each other. 6. This product combined with methyldopa can increase the adverse reactions of this product and enhance the antihypertensive effect of methyldopa.
Specifications	Levodopa 200 mg and benserazide 50 mg (equivalent to benserazide hydrochloride 57 mg)

Dopamine Capsules
Ingredients	This product is a compound preparation, its components are: levodopa and benserazide hydrochloride.
Indication	1. This product combined with non-selective monoamine oxidase inhibitors may cause acute adrenal crisis. 2. This product combined with papaverine or vitamin B6 may reduce the efficacy of this product. 3. This product combined with acetylspiramycin can significantly reduce the blood concentration of this product and weaken the efficacy. 4. This product combined with reserpine can inhibit the effect of this product and should be avoided. 5. This product combined with antipsychotic drugs should be avoided because the two antagonize each other. 6. This product combined with methyldopa can increase the adverse reactions of this product and enhance the antihypertensive effect of methyldopa.
Specifications	0.25g (levodopa: 0.2g, benserazide: 50mg)

Dopamine Capsules
Ingredients	This product is a compound preparation, its components are: levodopa and benserazide hydrochloride.
Indication	1. This product combined with non-selective monoamine oxidase inhibitors may cause acute adrenal crisis. 2. This product combined with papaverine or vitamin B6 may reduce the efficacy of this product. 3. This product combined with acetylspiramycin can significantly reduce the blood concentration of this product and weaken the efficacy. 4. This product combined with reserpine can inhibit the effect of this product and should be avoided. 5. This product combined with antipsychotic drugs should be avoided because the two antagonize each other. 6. This product combined with methyldopa can increase the adverse reactions of this product and enhance the antihypertensive effect of methyldopa.
Specifications	0.125g (levodopa: 0.1g, benserazide: 25mg)

See More Related Drugs

Registered Holders

Chongqing Shengkai Pharmaceutical Co., Ltd.

China
Active
Zhejiang Hengkang Pharmaceutical Co., Ltd.

China
Active
Nexchem Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

Recommended Suppliers of Benserazide hydrochloride

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Benserazide hydrochloride

CAS No.: 14919-77-8

Content: 99.00%

Inquiry
LUYUNJIA CHEMISTRY XIAMEN LIMITED Contact Supplier

CN
5 YRS

Business licensed

Distributor Supplier of DIMETHYL SULFOXIDE,NMP,MMT

Benserazide hydrochloride 14919-77-8

CAS No.: 14919-77-8

Content: 99%

Inquiry
ROYAL PHARM Contact Supplier

CN
4 YRS

Business licensed

Trader Supplier of additives,pharmaceutical chemicals,organic intermediate,chemical intermediates,Pharmaceutical Intermediates,catalyst,API

BENSERAZIDE HCl CAS No.14919-77-8

CAS No.: 14919-77-8

Grade: Pharmaceutical grade

Content: 99%

Inquiry
Hangzhou Chungyo Chemicals Co., Ltd. Contact Supplier

CN
3 YRS

Business licensed Certified factory

Manufactory Supplier of Dyes,Textile agent,Medical intermediate,API,Pigments,Basic Chemicals

Benserazide HCl

CAS No.: 14919-77-8

Grade: Industrial Grade

Content: 99%

Inquiry
Shandong Ailike New Material Technology Contact Supplier

CN
2 YRS

Business licensed

Trader Supplier of API,Antibiotics,Anti cancer category

Benserazidehydrochloride

Unit Price: $50 /MT EXW

CAS No.: 14919-77-8

Grade: Analytical Reagent

Content: 99%

Inquiry

Latest News on Benserazide hydrochloride

Learn More Other Chemicals

4H-1-Benzopyran-4-one, 2-[4-[3-(dibutylamino)propoxy]-3,5-dimethylbenzoyl]-, hydrochloride (1:1)

67652-33-9
Cyclopropanecarboxylic acid, 1-amino-2-ethenyl-, ethyl ester, hydrochloride (9CI)

681807-60-3
CYCLOPENTYL-(3,4,5-TRIMETHOXY-BENZYL)-AMINE HYDROCHLORIDE

1052525-88-8
2-Cyclopropylbenzenemethanamine hydrochloride Formula

118184-64-8
Des[4-(2-cycloproylMethoxy)] Betaxolol Hydrochloride Formula

464877-45-0
Ethanamine, 2-(decylthio)-, hydrochloride (1:1) Formula

36362-09-1
4,7-Dichloro-2-propylquinoline hydrochloride Structure

1204812-22-5
6,7-Dichloro-4-hydrazino-2-methylquinoline hydrochloride Structure

1170377-12-4
What is 2,8-Diazaspiro[4.5]decan-1-one, 2-[(4-bromophenyl)methyl]-, hydrochloride (1:1)

832710-56-2
What is 6,7-Dichloro-4-hydrazinoquinoline hydrochloride

1171843-02-9

Hot Searches: malonic acid; copper sulfide compound; methanol formula; monoammonium phosphate; chronic gastritis; cefpodoxime proxetil

Guide of Benserazide hydrochloride

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
Learn More Other Chemicals

Benserazide hydrochloride

SDS

Request for Quotation



Feedback & Suggestions

Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.